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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dosATPAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dosATPAurora kinase A2.7.11.11.000
4deeADPAurora kinase A2.7.11.10.567
5dnrATPAurora kinase A2.7.11.10.555
4c3pACPAurora kinase A2.7.11.10.501
3gu7ADPDeath-associated protein kinase 12.7.11.10.486
4jboWPHAurora kinase A2.7.11.10.486
4jbpYPHAurora kinase A2.7.11.10.480
1ig1ANPDeath-associated protein kinase 12.7.11.10.474
2yaaATPDeath-associated protein kinase 2/0.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.472
5dt4ATPAurora kinase A2.7.11.10.465
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.458
4qnyANPMitogen activated protein kinase, putative/0.458
4j95ACPFibroblast growth factor receptor 2/0.445
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.444
2w4jADPDeath-associated protein kinase 12.7.11.10.441
3c4wATPRhodopsin kinase/0.441
3bu5ATPInsulin receptor2.7.10.10.440
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440