sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5dif | GNP | GTP-binding nuclear protein Ran |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 1.000 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.755 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.644 | |
| 3rsl | GNP | GTPase HRas | / | 0.637 | |
| 3oiw | GNP | GTPase HRas | / | 0.636 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.632 | |
| 3rs7 | GNP | GTPase HRas | / | 0.630 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.626 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.624 | |
| 4g0n | GNP | GTPase HRas | / | 0.622 | |
| 4dsn | GCP | GTPase KRas | / | 0.618 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.618 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.615 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.614 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.614 | |
| 4dls | GNP | GTPase HRas | / | 0.613 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.609 | |
| 3lbn | GNP | GTPase HRas | / | 0.608 | |
| 3rs5 | GNP | GTPase HRas | / | 0.608 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.607 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.602 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.602 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.602 | |
| 2rgb | GNP | GTPase HRas | / | 0.599 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.598 | |
| 4k81 | GTP | GTPase HRas | / | 0.598 | |
| 3ddc | GNP | GTPase HRas | / | 0.597 | |
| 4dlt | GNP | GTPase HRas | / | 0.597 | |
| 3rs0 | GNP | GTPase HRas | / | 0.596 | |
| 3rs4 | GNP | GTPase HRas | / | 0.594 | |
| 3l8y | GNP | GTPase HRas | / | 0.593 | |
| 3v4f | GNP | GTPase HRas | / | 0.593 | |
| 4dlz | GNP | GTPase HRas | / | 0.593 | |
| 3wyg | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.591 | |
| 3lbh | GNP | GTPase HRas | / | 0.587 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.587 | |
| 5b2z | GNP | GTPase HRas | / | 0.587 | |
| 4dlv | GNP | GTPase HRas | / | 0.584 | |
| 4dlx | GNP | GTPase HRas | / | 0.584 | |
| 4nyj | GNP | GTPase HRas | / | 0.583 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.582 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.582 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.582 | |
| 3oiv | GNP | GTPase HRas | / | 0.582 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.582 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.581 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.581 | |
| 3kud | GDP | GTPase HRas | / | 0.581 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.580 | |
| 3i3s | GNP | GTPase HRas | / | 0.580 | |
| 2c5l | GTP | GTPase HRas | / | 0.578 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.578 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.578 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.577 | |
| 4mit | GTP | Rho-related protein racC | / | 0.575 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.574 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.574 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.571 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.571 | |
| 2rge | GNP | GTPase HRas | / | 0.570 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.570 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.569 | |
| 4dlw | GNP | GTPase HRas | / | 0.569 | |
| 4nyi | GNP | GTPase HRas | / | 0.568 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.564 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.563 | |
| 2rgc | GNP | GTPase HRas | / | 0.562 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.558 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.558 | |
| 3oiu | GNP | GTPase HRas | / | 0.557 | |
| 4l9w | GNP | GTPase HRas | / | 0.553 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.553 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.551 | |
| 3lbi | GNP | GTPase HRas | / | 0.551 | |
| 3bc1 | GNP | Ras-related protein Rab-27A | / | 0.549 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.549 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.547 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.544 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.543 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.543 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.542 | |
| 3k8y | GNP | GTPase HRas | / | 0.541 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.541 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.540 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.539 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.538 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.535 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.535 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.535 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.524 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.523 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.521 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.519 | |
| 4uj5 | GNP | Ras-related protein Rab-11A | / | 0.518 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.514 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.512 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.512 | |
| 4ql3 | GDP | GTPase KRas | / | 0.512 | |
| 4tq9 | GDP | GTPase KRas | / | 0.512 | |
| 4l8g | GDP | GTPase KRas | / | 0.511 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.510 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.510 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.510 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.510 | |
| 4ldj | GDP | GTPase KRas | / | 0.509 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.507 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.506 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.503 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.503 | |
| 4epx | GDP | GTPase KRas | / | 0.503 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.502 | |
| 3tnf | GNP | Ras-related protein Rab-8A | / | 0.502 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.501 | |
| 4dso | GSP | GTPase KRas | / | 0.500 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.499 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.497 | |
| 4lpk | GDP | GTPase KRas | / | 0.497 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.494 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.494 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.494 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.494 | |
| 4obe | GDP | GTPase KRas | / | 0.493 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.492 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.490 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.489 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.488 | |
| 3tgp | GNP | GTPase HRas | / | 0.488 | |
| 4luc | GDP | GTPase KRas | / | 0.488 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.487 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.487 | |
| 4cym | GCP | Ras-related protein Rab-32 | / | 0.487 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.487 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.486 | |
| 4q02 | GDP | GTPase KRas | / | 0.486 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.484 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.484 | |
| 3tkl | GTP | Ras-related protein Rab-1A | / | 0.484 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.484 | |
| 4l9s | GDP | GTPase HRas | / | 0.483 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.482 | |
| 2ce2 | GDP | GTPase HRas | / | 0.481 | |
| 4epw | GDP | GTPase KRas | / | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.480 | |
| 4lv6 | GDP | GTPase KRas | / | 0.480 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.478 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.478 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.478 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.476 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4q03 | GDP | GTPase KRas | / | 0.476 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.475 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.474 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.474 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.473 | |
| 4dsu | GDP | GTPase KRas | / | 0.473 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.472 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.471 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.471 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.470 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.469 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.469 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2r8o | T5X | Transketolase 1 | / | 0.468 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4xvq | GNP | GTPase HRas | / | 0.468 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.467 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.466 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.466 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.466 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.466 | |
| 4wa7 | GDP | GTPase KRas | / | 0.466 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.465 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.465 | |
| 3pz4 | 3PZ | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.465 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.465 | |
| 4lrw | GDP | GTPase KRas | / | 0.465 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.464 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.464 | |
| 4jic | FMN | GTN Reductase | / | 0.464 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.463 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.463 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.463 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.463 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.463 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.462 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.462 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.462 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.461 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.461 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.461 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.461 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.460 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.460 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.460 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.460 | |
| 4rrc | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.460 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.459 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.459 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.459 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.459 | |
| 1g6o | ADP | Cag alpha | / | 0.458 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.458 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.458 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.458 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.457 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4ihj | GTP | Tubulin alpha-1B chain | / | 0.457 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.457 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.456 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.456 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.456 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.456 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.456 | |
| 1a4r | GNH | Cell division control protein 42 homolog | / | 0.455 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.455 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.455 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.454 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.454 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.454 | |
| 2bxq | IMN | Serum albumin | / | 0.454 | |
| 2rgg | GNP | GTPase HRas | / | 0.454 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.454 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.454 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.453 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.453 | |
| 1ppj | ANY | Cytochrome b | / | 0.453 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.453 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 2py7 | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.453 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.452 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.452 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.452 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.452 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.452 | |
| 4hxy | NDP | Plm1 | / | 0.452 | |
| 4wbn | GTP | Tubulin alpha-1B chain | / | 0.452 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.451 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.451 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.451 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.451 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.451 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.451 | |
| 4y0v | GDP | ADP-ribosylation factor 1, putative | / | 0.451 | |
| 5jqg | GTP | Tubulin alpha-1B chain | / | 0.451 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.450 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.450 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.450 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.450 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.450 | |
| 4kxj | P34 | Nucleoprotein | / | 0.450 | |
| 4lut | DCS | Alanine racemase | / | 0.450 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.450 | |
| 1m2o | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.449 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.449 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.449 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.449 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.449 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.449 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.449 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.449 | |
| 4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.449 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.449 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.448 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.448 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.448 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.448 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.448 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.448 | |
| 4lww | LWW | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.448 | |
| 4nu6 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.448 | |
| 4tuy | GTP | Tubulin alpha-1B chain | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.447 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.447 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.447 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.447 | |
| 3qge | 26F | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.447 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.446 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.446 | |
| 2vcq | D25 | Hematopoietic prostaglandin D synthase | / | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.446 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3kxo | KXO | Hematopoietic prostaglandin D synthase | / | 0.446 | |
| 3ndj | JHZ | Methyltransferase | / | 0.446 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.446 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.446 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.446 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4oi2 | ADP | Protein clpf-1 | / | 0.446 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.446 | |
| 4zo3 | C6L | Acylhomoserine lactonase | / | 0.446 | |
| 1lfd | GNP | GTPase HRas | / | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.445 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.445 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.445 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3k9l | GNP | GTPase HRas | / | 0.445 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.445 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.445 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.445 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.445 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.444 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.444 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.444 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.444 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.443 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3up0 | D7S | aceDAF-12 | / | 0.443 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.443 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.443 | |
| 4ylg | GDP | ADP-ribosylation factor 1, putative | / | 0.443 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1n08 | ADP | Riboflavin kinase | 2.7.1.26 | 0.442 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.442 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.442 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.442 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.442 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.442 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4d9f | DCS | D-cysteine desulfhydrase | / | 0.442 | |
| 4xvr | GNP | GTPase HRas | / | 0.442 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1n5t | OAL | ActVA 6 protein | / | 0.441 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.441 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.441 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.441 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.441 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.441 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.441 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.441 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.440 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.440 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.440 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.440 | |
| 2o12 | FMN | Chorismate synthase | / | 0.440 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.440 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.440 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.440 |