sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5dhg | DGV | Nociceptin receptor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5dhg | DGV | Nociceptin receptor | / | 1.000 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.681 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.594 | |
| 4ej4 | EJ4 | Delta-type opioid receptor | / | 0.549 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.542 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.504 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.497 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.496 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.496 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.495 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.492 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.490 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.490 | |
| 4u7w | NDP | MxaA | / | 0.490 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.489 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.488 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.488 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.487 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.486 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.485 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.483 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.481 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.480 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.480 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.480 | |
| 2acw | UPG | Glycosyltransferase | / | 0.479 | |
| 2oz6 | CMP | Cyclic AMP receptor-like protein | / | 0.479 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.478 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.478 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.478 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.478 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.477 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.477 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.475 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.475 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.475 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.473 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.472 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.472 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.472 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.472 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.471 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.471 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.470 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.469 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.469 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.468 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.468 | |
| 4mcc | 21X | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.468 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.467 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.466 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.466 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.466 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.466 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.466 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.466 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.466 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.465 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.465 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.464 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.464 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.463 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.463 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.463 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.462 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.462 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.462 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.462 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.462 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.462 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1snu | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.461 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.461 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.461 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.460 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.460 | |
| 3ecg | 065 | Gag-Pol polyprotein | 3.4.23.47 | 0.460 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.460 | |
| 4dt9 | GMP | APH(2'')-Id | / | 0.460 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 4yqf | GDP | Septin-9 | / | 0.460 | |
| 5d3f | FSC | 14-3-3 protein zeta/delta | / | 0.460 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.460 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.459 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.459 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.459 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.459 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.459 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.458 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.458 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.458 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.457 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.457 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 3nhx | ASD | Steroid Delta-isomerase | 5.3.3.1 | 0.457 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 2ph8 | 35A | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.456 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.456 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.456 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.455 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.455 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.455 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.455 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2prz | OMP | Orotate phosphoribosyltransferase 1 | 2.4.2.10 | 0.454 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.454 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.454 | |
| 3s0o | 50Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.454 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.453 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.453 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.453 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 1jq3 | AAT | Polyamine aminopropyltransferase | / | 0.452 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2x8e | X8E | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 3d7t | STU | Tyrosine-protein kinase CSK | / | 0.452 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.452 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.452 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.452 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.452 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.452 | |
| 1bv9 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.451 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2y3s | TIR | TamL | / | 0.451 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.451 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.451 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.451 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.451 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4ijr | NDP | D-arabinose dehydrogenase [NAD(P)+] heavy chain | 1.1.1.117 | 0.451 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.450 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.450 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.450 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.450 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.450 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.449 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.449 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.449 | |
| 4ekl | 0RF | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.449 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1r2j | FAD | FkbI | / | 0.448 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.448 | |
| 2olr | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.448 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.448 | |
| 2wmv | ZYV | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3pvw | QRX | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.448 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 4qjq | OTR | Lactoperoxidase | / | 0.448 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.447 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.447 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.447 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.447 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.447 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.447 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.447 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.446 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.446 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.446 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2r64 | 740 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.446 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.446 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4z0g | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.446 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.445 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.445 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2vww | 7X2 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.445 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3qrt | X14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.445 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.445 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.444 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.444 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.444 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.444 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.444 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.444 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.444 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.444 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.444 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.444 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4z9r | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.444 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.443 | |
| 1thy | UMP | Thymidylate synthase | / | 0.443 | |
| 1unh | IXM | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.443 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.443 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.443 | |
| 2itw | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 2olq | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.443 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.443 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3rdo | BTN | Streptavidin | / | 0.443 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.443 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.443 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4qpp | SAH | Protein arginine N-methyltransferase 6 | / | 0.443 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.442 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.442 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.442 | |
| 3qih | FG7 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.442 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.442 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4h6p | FMN | Chromate reductase | / | 0.442 | |
| 1c70 | L75 | Protease | / | 0.441 | |
| 1kh2 | ATP | Argininosuccinate synthase | / | 0.441 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.441 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.441 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.441 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2zm4 | KSM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 3dmh | SAM | Probable ribosomal RNA small subunit methyltransferase | / | 0.441 | |
| 3g7j | GTX | Glutathione transferase GST1-4 | / | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.441 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.441 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.441 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1h0w | 207 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.440 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.440 | |
| 2pid | YSA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.440 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.440 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2xvw | 9NR | Serum albumin | / | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.440 | |
| 3pvu | QRW | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.440 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4ehu | ANP | 2-hydroxyisocaproyl-CoA dehydratase activator | / | 0.440 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.440 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.440 |