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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.607
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.597
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.571
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.567
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.567
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.563
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.556
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.556
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.554
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.544
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.544
2ol4JPNEnoyl-ACP reductase/0.536
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.535
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.534
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.532
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.528
1zsnTN2Enoyl-ACP reductase/0.527
1zxlJP1Enoyl-ACP reductase/0.498
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.491
4j6bPLOCytochrome P450 monooxygenase/0.481
4j6cSTRCytochrome P450 monooxygenase/0.473
4jbtASDCytochrome P450 monooxygenase/0.470
3nj8NJ8Enoyl-acyl carrier reductase/0.467
1pkfEPDEpothilone C/D epoxidase1.140.466
1n83CLRNuclear receptor ROR-alpha/0.465
3mg3ECHOrange carotenoid-binding protein/0.463
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.463
1iyzNDPProbable quinone oxidoreductase/0.459
1zw1TN5Enoyl-ACP reductase/0.459
3f4bTCLEnoyl-acyl carrier protein reductase/0.457
3p6mDSOCamphor 5-monooxygenase1.14.15.10.457
3tdaPN0Cytochrome P450 2D6/0.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
1e1mFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.452
1s0xC3SNuclear receptor ROR-alpha/0.452
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
1ndzFR5Adenosine deaminase3.5.4.40.451
2o2sTCLEnoyl-acyl carrier reductase/0.451
4at0FADPossible succinate dehydrogenase/0.451
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.449
4q71FADBifunctional protein PutA/0.449
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
5uviZMAAdenosine receptor A2a/0.448
1rf9DBRCamphor 5-monooxygenase1.14.15.10.445
3pqbVGPPutative oxidoreductase/0.445
4j6dTESCytochrome P450 monooxygenase/0.445
4r20AERCytochrome P450 family 17 polypeptide 2/0.445
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.444
5fsxADPUncharacterized protein/0.444
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3p6nDSOCamphor 5-monooxygenase1.14.15.10.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
5k2bZMAAdenosine receptor A2a/0.442
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1knrFADL-aspartate oxidase1.4.3.160.441
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.441
4nt3ZAWLactoperoxidase1.11.1.70.441
1ci7CB3Thymidylate synthase2.1.1.450.440
1jioDEB6-deoxyerythronolide B hydroxylase/0.440
1nnuTCTEnoyl-ACP reductase/0.440
1poxFADPyruvate oxidase1.2.3.30.440
3abaFLICytochrome P450/0.440
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440