sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.769 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.682 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.669 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.620 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.592 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.585 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.583 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.583 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.583 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.582 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.582 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.574 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.556 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.552 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.530 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.519 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.517 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.516 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.510 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.509 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.502 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.501 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.499 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.498 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.495 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.493 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.492 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.491 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.487 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.484 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.481 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.480 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.476 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.475 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.474 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.474 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.473 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.472 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.469 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.466 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.462 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.462 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.460 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.460 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.460 | |
| 4egn | TWO | Cytochrome P450 | / | 0.459 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.458 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.458 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.456 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.456 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.453 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.453 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.451 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.450 | |
| 2y3s | TIR | TamL | / | 0.449 | |
| 2y3r | TRK | TamL | / | 0.448 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.448 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.447 | |
| 2y4g | TIR | TamL | / | 0.447 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.445 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.442 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.441 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.440 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.440 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 |