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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5ce3ADPProtein kinase YopO

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5ce3ADPProtein kinase YopO/1.000
4gyiADPUncharacterized protein/0.484
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.469
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.466
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.466
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.466
3wowANPCasein kinase II subunit alpha2.7.11.10.464
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
1tvoFRZMitogen-activated protein kinase 12.7.11.240.460
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.460
3nszANPCasein kinase II subunit alpha2.7.11.10.457
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.456
4zohFADPutative oxidoreductase FAD-binding subunit/0.452
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
4f07FADStyrene monooxygenase component 2/0.449
1jnkANPMitogen-activated protein kinase 102.7.11.240.448
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.448
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4dcaADPAminoglycoside phosphotransferase/0.448
1w87NAPFerredoxin--NADP reductase1.18.1.20.447
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.445
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.445
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.445
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3ub5ATPActin, cytoplasmic 1/0.445
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.445
3frqERYErythromycin resistance repressor protein/0.444
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.441
4k33ACPFibroblast growth factor receptor 32.7.10.10.441
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.440
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.440
2p33J07Mitogen-activated protein kinase 102.7.11.240.440
3ormAGSSerine/threonine protein kinase/0.440