sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 1.000 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.593 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.587 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.547 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.510 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.494 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.494 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.492 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.490 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.489 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.489 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.488 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.487 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.483 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.483 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.481 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.481 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.480 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.480 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.480 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.478 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.477 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.476 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.475 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.474 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.472 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.472 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.471 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.471 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.471 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.471 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.471 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.470 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.470 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.469 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.468 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.468 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.467 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.467 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.466 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.466 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.466 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.466 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.465 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.465 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.465 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.465 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.464 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.464 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 4jic | FMN | GTN Reductase | / | 0.464 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.464 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.463 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.462 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.461 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.461 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.461 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.461 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2ejz | SAH | Diphthine synthase | / | 0.460 | |
| 3a3g | DLZ | Lumazine protein | / | 0.460 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3ieu | GDP | GTPase Era | / | 0.460 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.460 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4oi4 | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.460 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.459 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.459 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.459 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.459 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.459 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.459 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.458 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.458 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.458 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.457 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.457 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.456 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.456 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.456 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.456 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.456 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.456 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.456 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.456 | |
| 4usr | FAD | Monooxygenase | / | 0.456 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.455 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.455 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.455 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.455 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.455 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.454 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.454 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.454 | |
| 1l5r | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.454 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.454 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.454 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.453 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.453 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.453 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.453 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.453 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.453 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.452 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.452 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.452 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.452 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.452 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.451 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.451 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.451 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.451 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.451 | |
| 2dsg | SAH | Diphthine synthase | / | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2pid | YSA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.450 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.450 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.450 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.450 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.450 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.450 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.449 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.449 | |
| 2qrq | S13 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.449 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.449 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.449 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.449 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.449 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.449 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 5ftf | ADP | TPR domain protein | / | 0.449 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.448 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.448 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.448 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.448 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.448 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.448 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.448 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.448 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.448 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.448 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.448 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.448 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.447 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.447 | |
| 2x95 | X95 | Angiotensin-converting enzyme | 3.4.15.1 | 0.447 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.447 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.447 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.447 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.446 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.446 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.446 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.445 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.445 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.445 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.445 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.445 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.445 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.445 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.445 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.445 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.444 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.444 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.444 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.444 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.444 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.443 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.443 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.443 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.443 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.443 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 3wag | TYD | Glycosyltransferase | / | 0.443 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.443 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.443 | |
| 1a9p | 9DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1ds7 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2p6l | SAH | Diphthine synthase | / | 0.442 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.442 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.442 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.442 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 4gi5 | FAD | Putative NAD(P)H dehydrogenase (Quinone) | / | 0.442 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.442 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.442 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.442 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1j37 | X8Z | Angiotensin-converting enzyme | 3.4.15.1 | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.441 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.441 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.441 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.441 | |
| 3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.441 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3tb9 | CDP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.441 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4u7w | NDP | MxaA | / | 0.441 | |
| 5cfp | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.440 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.440 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.440 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.440 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.440 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.440 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.440 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.440 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.440 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.440 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.440 | |
| 4lut | DCS | Alanine racemase | / | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.440 |