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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5av3KMPDeath-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5av3KMPDeath-associated protein kinase 12.7.11.11.000
5av2KMPDeath-associated protein kinase 12.7.11.10.833
1jklANPDeath-associated protein kinase 12.7.11.10.632
3gu7ADPDeath-associated protein kinase 12.7.11.10.620
5aut2ANDeath-associated protein kinase 12.7.11.10.591
2yaaATPDeath-associated protein kinase 2/0.586
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.580
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.563
2w4jADPDeath-associated protein kinase 12.7.11.10.561
1ig1ANPDeath-associated protein kinase 12.7.11.10.549
5cvfATPCasein kinase II subunit alpha2.7.11.10.549
3lltANPProtein serine/threonine kinase-1/0.548
1jkkANPDeath-associated protein kinase 12.7.11.10.546
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.543
5auwQUEDeath-associated protein kinase 12.7.11.10.540
5auvAGIDeath-associated protein kinase 12.7.11.10.539
3dfcANPDeath-associated protein kinase 12.7.11.10.535
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.535
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.534
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.534
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.526
5av047XDeath-associated protein kinase 12.7.11.10.524
5auxKMPDeath-associated protein kinase 12.7.11.10.523
2ijmADPFocal adhesion kinase 12.7.10.20.521
3juhANPCasein kinase II subunit alpha2.7.11.10.518
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.517
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.516
3i60E86Mitogen-activated protein kinase 12.7.11.240.513
4ysjADPCalmodulin-like domain protein kinase/0.513
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.512
4j99ACPFibroblast growth factor receptor 2/0.512
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.512
3bqr4RBDeath-associated protein kinase 3/0.510
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.507
5dosATPAurora kinase A2.7.11.10.507
4qnyANPMitogen activated protein kinase, putative/0.506
2ckeIQUDeath-associated protein kinase 2/0.505
2j0lANPFocal adhesion kinase 12.7.10.20.505
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.502
2vu3LZECyclin-dependent kinase 22.7.11.220.502
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.502
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.501
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.500
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.500
4l9i8PRRhodopsin kinase/0.499
3gu6ADPDeath-associated protein kinase 12.7.11.10.498
4anmWULCasein kinase II subunit alpha2.7.11.10.498
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.497
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.497
1m2pHNACasein kinase II subunit alpha2.7.11.10.496
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.496
3igoANPCalmodulin-domain protein kinase 1, putative/0.495
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.495
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
4xlvACPInsulin receptor2.7.10.10.494
1pjkANPCasein kinase II subunit alpha2.7.11.10.493
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.493
4aguD15Cyclin-dependent kinase-like 1/0.492
4btjATPTau-tubulin kinase 12.7.11.10.492
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.492
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.491
4fv6E57Mitogen-activated protein kinase 12.7.11.240.490
2j0m4STFocal adhesion kinase 12.7.10.20.489
3c4xATPRhodopsin kinase/0.489
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.489
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.489
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.489
3zxtACPDeath-associated protein kinase 12.7.11.10.488
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
3at4CCKCasein kinase II subunit alpha2.7.11.10.487
4axdANPInositol-pentakisphosphate 2-kinase2.7.1.1580.487
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.487
3gu83GUDeath-associated protein kinase 12.7.11.10.486
4jbpYPHAurora kinase A2.7.11.10.486
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
2ijmATPFocal adhesion kinase 12.7.10.20.485
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.485
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.485
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.485
3be9P04Casein kinase II subunit alpha2.7.11.10.484
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.484
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.484
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.483
4btjADPTau-tubulin kinase 12.7.11.10.483
4eooATPCyclin-dependent kinase 22.7.11.220.483
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.482
3bhy7CPDeath-associated protein kinase 3/0.481
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.480
3u4uLNHCasein kinase II subunit alpha2.7.11.10.480
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.479
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.478
2zjwREFCasein kinase II subunit alpha2.7.11.10.478
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.478
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.478
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.478
4grb0XGCasein kinase II subunit alpha2.7.11.10.478
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
2ojj82AMitogen-activated protein kinase 12.7.11.240.477
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.477
4o0wADNAurora kinase A2.7.11.10.477
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.476
2xanANPInositol-pentakisphosphate 2-kinase2.7.1.1580.475
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.475
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.475
5av4GENDeath-associated protein kinase 12.7.11.10.475
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.474
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.474
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.474
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.474
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3t8oATPRhodopsin kinase/0.473
4h3qANPMitogen-activated protein kinase 12.7.11.240.473
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.473
4j95ACPFibroblast growth factor receptor 2/0.473
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2uzbC75Cyclin-dependent kinase 22.7.11.220.472
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.472
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.472
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.472
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.470
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
1fvv107Cyclin-dependent kinase 22.7.11.220.469
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.468
1wvxBD4Death-associated protein kinase 12.7.11.10.468
3bu5ATPInsulin receptor2.7.10.10.468
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.468
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.467
2c7xNRBCytochrome P450 monooxygenase PikC/0.467
2vv9IM9Cyclin-dependent kinase 22.7.11.220.467
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4c3pACPAurora kinase A2.7.11.10.467
4jboWPHAurora kinase A2.7.11.10.467
1wvySTUDeath-associated protein kinase 12.7.11.10.466
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.466
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.466
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4ic7ANPMitogen-activated protein kinase 72.7.11.240.466
5dnrATPAurora kinase A2.7.11.10.466
3a8wATPProtein kinase C iota type2.7.11.130.465
3w2sW2REpidermal growth factor receptor2.7.10.10.465
4hge15VTyrosine-protein kinase JAK2/0.465
5auzGENDeath-associated protein kinase 12.7.11.10.465
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.464
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.464
3orpAGSSerine/threonine protein kinase/0.464
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.464
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.464
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.463
2cjmATPCyclin-dependent kinase 22.7.11.220.463
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.463
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.463
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.463
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.462
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.462
4deeADPAurora kinase A2.7.11.10.462
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.462
4ez50RSCyclin-dependent kinase 62.7.11.220.462
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.462
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3begANPSRSF protein kinase 12.7.11.10.461
3gubGUBDeath-associated protein kinase 12.7.11.10.461
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.461
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.460
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.460
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2etm7PYFocal adhesion kinase 12.7.10.20.459
2vrx447Aurora kinase B-A2.7.11.10.459
3lpbNVBTyrosine-protein kinase JAK2/0.459
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.459
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.458
2ca0PXICytochrome P450 monooxygenase PikC/0.458
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.458
2pvnP63Casein kinase II subunit alpha2.7.11.10.457
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3q9xEMOCasein kinase II subunit alpha2.7.11.10.457
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.456
1yvj4STTyrosine-protein kinase JAK32.7.10.20.456
2cciATPCyclin-dependent kinase 22.7.11.220.456
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.456
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.456
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.456
3ortAGSSerine/threonine protein kinase/0.456
3pe2E1BCasein kinase II subunit alpha2.7.11.10.456
4aqkADPInositol-pentakisphosphate 2-kinase2.7.1.1580.456
4o0uADNAurora kinase A2.7.11.10.456
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.455
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.455
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
2pvmP29Casein kinase II subunit alpha2.7.11.10.455
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3a62STURibosomal protein S6 kinase beta-12.7.11.10.454
3c4zADPRhodopsin kinase/0.454
3r9dX6BCyclin-dependent kinase 22.7.11.220.454
4hvi19STyrosine-protein kinase JAK32.7.10.20.454
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
5e8ySTUTGF-beta receptor type-22.7.11.300.454
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.453
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4b7sQLECytochrome P450 monooxygenase PikC/0.453
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.452
3ncz3NCRho-associated protein kinase 12.7.11.10.452
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4jia1K3Tyrosine-protein kinase JAK2/0.452
4qmlANPSerine/threonine-protein kinase 242.7.11.10.452
4s33ANPMitogen-activated protein kinase 12.7.11.240.452
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.451
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.451
2y9qANPMitogen-activated protein kinase 12.7.11.240.451
3zdu38RCyclin-dependent kinase-like 32.7.11.220.451
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
4jrnANPRhoptry kinase family protein/0.450
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.450
4uuxAPRCinA-like protein/0.450
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
2etrY27Rho-associated protein kinase 12.7.11.10.449
2w17I19Cyclin-dependent kinase 22.7.11.220.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.449
2ad5ADPCTP synthase/0.448
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.448
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.448
1bygSTUTyrosine-protein kinase CSK/0.447
1finATPCyclin-dependent kinase 22.7.11.220.447
1ppm0P1Penicillopepsin-13.4.23.200.447
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.447
2fvdLIACyclin-dependent kinase 22.7.11.220.447
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
4ix6ADPUncharacterized protein/0.447
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.447
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.446
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.446
2w05FRTCyclin-dependent kinase 22.7.11.220.446
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
2c6hPXICytochrome P450 monooxygenase PikC/0.445
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2zoq5IDMitogen-activated protein kinase 32.7.11.240.444
3nieANPMitogen-activated protein kinase/0.444
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.444
3zewSTUEphrin type-B receptor 42.7.10.10.444
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4dtaADNAPH(2'')-Id/0.444
4l06NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
4otiMI1Serine/threonine-protein kinase N1/0.444
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1pmn984Mitogen-activated protein kinase 102.7.11.240.443
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2hog710Serine/threonine-protein kinase Chk12.7.11.10.443
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4e6d0NUTyrosine-protein kinase JAK2/0.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
4lrjANPUncharacterized protein/0.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.442
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.442
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.442
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.441
2henADPEphrin type-B receptor 22.7.10.10.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.441
4axfANPInositol-pentakisphosphate 2-kinase2.7.1.1580.441
4ii5ADPCyclin-dependent kinase 22.7.11.220.441
4lfiGNPCasein kinase II subunit alpha2.7.11.10.441
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3d5wADPSerine/threonine-protein kinase PLK/0.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3s2pPMUCyclin-dependent kinase 22.7.11.220.440
4crsAGSSerine/threonine-protein kinase N22.7.11.130.440
4fv9E71Mitogen-activated protein kinase 12.7.11.240.440
4i3zADPCyclin-dependent kinase 22.7.11.220.440
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440