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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.11.000
3hmm855TGF-beta receptor type-12.7.11.300.545
1eh4IC1Casein kinase I homolog 12.7.11.10.529
3gxlQIGTGF-beta receptor type-12.7.11.300.527
4dymIYZActivin receptor type-12.7.11.300.515
4bgg844Activin receptor type-12.7.11.300.506
3uyt0CKCasein kinase I isoform delta2.7.11.10.505
5e8wSTUTGF-beta receptor type-12.7.11.300.505
4f650S9Fibroblast growth factor receptor 1/0.497
4kbk1QGCasein kinase I isoform delta2.7.11.10.495
4c02TAKActivin receptor type-12.7.11.300.494
4aqc88ATyrosine-protein kinase JAK2/0.492
3uzp0CKCasein kinase I isoform delta2.7.11.10.490
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.489
2pvhP19Casein kinase II subunit alpha2.7.11.10.489
1u4dDBQActivated CDC42 kinase 1/0.487
4lopSB4Mitogen-activated protein kinase 14/0.486
3zh8C58Protein kinase C iota type2.7.11.130.485
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.485
1dawANPCasein kinase II subunit alpha2.7.11.10.484
1g5sI17Cyclin-dependent kinase 22.7.11.220.484
5cnnANPEpidermal growth factor receptor2.7.10.10.484
4hge15VTyrosine-protein kinase JAK2/0.483
4loqSB4Mitogen-activated protein kinase 14/0.483
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.483
4kb81QOCasein kinase I isoform delta2.7.11.10.482
4j95ACPFibroblast growth factor receptor 2/0.481
4ji91M3Tyrosine-protein kinase JAK2/0.481
4hvi19STyrosine-protein kinase JAK32.7.10.20.480
1rfvADPPyridoxal kinase2.7.1.350.479
3gubGUBDeath-associated protein kinase 12.7.11.10.479
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.477
1yvj4STTyrosine-protein kinase JAK32.7.10.20.477
3be9P04Casein kinase II subunit alpha2.7.11.10.477
3s1h56ZCyclin-dependent kinase 22.7.11.220.476
1rw8580TGF-beta receptor type-12.7.11.300.475
2ghlLIBMitogen-activated protein kinase 14/0.475
3mtfA3FActivin receptor type-12.7.11.300.475
4ez50RSCyclin-dependent kinase 62.7.11.220.475
4yuqKS1Calmodulin-like domain protein kinase/0.475
5cnoANPEpidermal growth factor receptor2.7.10.10.475
1lbcCYZGlutamate receptor 2/0.474
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.474
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.474
1m2pHNACasein kinase II subunit alpha2.7.11.10.473
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.473
4i22IREEpidermal growth factor receptor2.7.10.10.473
4jia1K3Tyrosine-protein kinase JAK2/0.473
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.473
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.472
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1u54ACPActivated CDC42 kinase 1/0.471
4hnf16WCasein kinase I isoform delta2.7.11.10.471
1gih1PUCyclin-dependent kinase 22.7.11.220.470
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.470
4iwd1JCHepatocyte growth factor receptor2.7.10.10.469
1hbvGANGag-Pol polyprotein/0.468
1om1IQACasein kinase II subunit alpha2.7.11.10.467
1xjdSTUProtein kinase C theta type2.7.11.130.467
3q43D66M1 family aminopeptidase3.4.110.467
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.467
1rfuADPPyridoxal kinase2.7.1.350.466
3oom507Activin receptor type-12.7.11.300.466
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2ien017Gag-Pol polyprotein3.4.23.160.465
3tqhNDPQuinone oxidoreductase/0.465
2pmoHMDProtein kinase 7/0.464
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.463
1csnATPCasein kinase I homolog 12.7.11.10.463
4a4qUX9Pol protein/0.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
3rmf20ZCyclin-dependent kinase 22.7.11.220.462
4btjADPTau-tubulin kinase 12.7.11.10.462
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.462
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.462
1bsvNDPGDP-L-fucose synthase/0.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2pvlP55Casein kinase II subunit alpha2.7.11.10.461
2x1nX1NCyclin-dependent kinase 22.7.11.220.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
2b53D23Cyclin-dependent kinase 22.7.11.220.460
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
4ic7ANPMitogen-activated protein kinase 72.7.11.240.460
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.459
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
2p3b3TLV-1 PROTEASE protein/0.459
2p3b3TLV-1 protease/0.459
2vww7X2Ephrin type-B receptor 42.7.10.10.459
4e4m0NHTyrosine-protein kinase JAK2/0.459
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.458
2xa4AZ5Tyrosine-protein kinase JAK2/0.458
5e8xSTUTGF-beta receptor type-12.7.11.300.458
1oirHDYCyclin-dependent kinase 22.7.11.220.457
2b52D42Cyclin-dependent kinase 22.7.11.220.457
2izrBRKCasein kinase I isoform gamma-32.7.11.10.457
2v7a627Tyrosine-protein kinase ABL12.7.10.20.457
1bwsNDPGDP-L-fucose synthase/0.456
1bygSTUTyrosine-protein kinase CSK/0.456
1jpaANPEphrin type-B receptor 22.7.10.10.456
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.456
3nwq2NCGag-Pol polyprotein3.4.23.160.456
4anmWULCasein kinase II subunit alpha2.7.11.10.456
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.456
4f081RSTyrosine-protein kinase JAK2/0.456
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
4k33ACPFibroblast growth factor receptor 32.7.10.10.456
4lfiGNPCasein kinase II subunit alpha2.7.11.10.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
2r3jSCJCyclin-dependent kinase 22.7.11.220.455
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.455
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.455
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.455
3ibqATPPyridoxal kinase/0.455
3slkNDPPolyketide synthase extender module 2/0.455
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.455
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.455
4enhFVXCholesterol 24-hydroxylase/0.455
4gg70J8Hepatocyte growth factor receptor2.7.10.10.455
1fxsNAPGDP-L-fucose synthase/0.454
2b7aIZATyrosine-protein kinase JAK2/0.454
2cchATPCyclin-dependent kinase 22.7.11.220.454
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.454
3own3OWRenin3.4.23.150.453
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
2iw94SPCyclin-dependent kinase 22.7.11.220.452
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.452
4y93746Tyrosine-protein kinase/0.452
5e8ySTUTGF-beta receptor type-22.7.11.300.452
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1zz2B11Mitogen-activated protein kinase 14/0.451
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.451
2pvnP63Casein kinase II subunit alpha2.7.11.10.451
2vv9IM9Cyclin-dependent kinase 22.7.11.220.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.451
3zewSTUEphrin type-B receptor 42.7.10.10.451
4aacAAVMitogen-activated protein kinase 14/0.451
5e92ANPTGF-beta receptor type-22.7.11.300.451
1vikBAYGag-Pol polyprotein/0.450
1w6hTITPlasmepsin-23.4.23.390.450
1xkkFMMEpidermal growth factor receptor2.7.10.10.450
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.450
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.450
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.450
4ewqMWLMitogen-activated protein kinase 14/0.450
4fkv61KCyclin-dependent kinase 22.7.11.220.450
4hvg19QTyrosine-protein kinase JAK32.7.10.20.450
1dayGNPCasein kinase II subunit alpha2.7.11.10.449
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.449
1xddAAYIntegrin alpha-L/0.449
1xl5190Gag-Pol polyprotein3.4.23.160.449
1yb5NAPQuinone oxidoreductase1.6.5.50.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
2xvdAS6Ephrin type-B receptor 42.7.10.10.449
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.449
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
3zxzKRWHepatocyte growth factor receptor2.7.10.10.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.449
4r20AERCytochrome P450 family 17 polypeptide 2/0.449
1y91CT9Cyclin-dependent kinase 22.7.11.220.448
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.448
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.448
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.448
1di8DTQCyclin-dependent kinase 22.7.11.220.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.447
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
3dt1P40Mitogen-activated protein kinase 14/0.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.446
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.446
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.446
3keuATPPyridoxal kinase2.7.1.350.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
1p2a5BNCyclin-dependent kinase 22.7.11.220.445
2b56UTPRNA editing complex protein MP57/0.445
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.445
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.445
2xyuQ9GEphrin type-A receptor 42.7.10.10.445
3hllI45Mitogen-activated protein kinase 14/0.445
3lfqA28Cyclin-dependent kinase 22.7.11.220.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3r83Z14Cyclin-dependent kinase 22.7.11.220.445
4e6d0NUTyrosine-protein kinase JAK2/0.445
1ir3ANPInsulin receptor2.7.10.10.444
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.444
2owkSAHDiphthine synthase/0.444
2w3bNDPDihydrofolate reductase1.5.1.30.444
2z54AB1Gag-Pol polyprotein3.4.23.160.444
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.444
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.443
1k6pXN3Gag-Pol polyprotein3.4.23.160.443
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.443
2pwlACPFibroblast growth factor receptor 2/0.443
3lpbNVBTyrosine-protein kinase JAK2/0.443
3w32W32Epidermal growth factor receptor2.7.10.10.443
4a6cQG9Gag-Pol polyprotein3.4.23.160.443
4aosFADSteroid monooxygenase/0.443
4c61LMMTyrosine-protein kinase JAK2/0.443
4fod0UVALK tyrosine kinase receptor2.7.10.10.443
4qmpDKISerine/threonine-protein kinase 242.7.11.10.443
4qmzB49Serine/threonine-protein kinase 242.7.11.10.443
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.442
1pxoCK7Cyclin-dependent kinase 22.7.11.220.442
1qrpHH0Pepsin A-43.4.23.10.442
1y4lSVRBasic phospholipase A2 homolog 2/0.442
1zrzBI1Protein kinase C iota type2.7.11.130.442
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
2uzeC95Cyclin-dependent kinase 22.7.11.220.442
2w17I19Cyclin-dependent kinase 22.7.11.220.442
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.442
3ggfGVDSerine/threonine-protein kinase 26/0.442
3lpkZ76Beta-secretase 13.4.23.460.442
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4riyADPEpidermal growth factor receptor2.7.10.10.442
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.441
1kkq471Peroxisome proliferator-activated receptor alpha/0.441
1me6IVSPlasmepsin-23.4.23.390.441
1pmn984Mitogen-activated protein kinase 102.7.11.240.441
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.441
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2zdt46CMitogen-activated protein kinase 102.7.11.240.441
4bcoT6QCyclin-dependent kinase 22.7.11.220.441
4dfg0JVGag-Pol polyprotein3.4.23.160.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
1x8lOXRRetinol dehydratase/0.440
2c6o4SPCyclin-dependent kinase 22.7.11.220.440
2ejvNADL-threonine 3-dehydrogenase/0.440
2w06FRVCyclin-dependent kinase 22.7.11.220.440
3oqkS52Renin3.4.23.150.440
3to6LYS_CMCHistone acetyltransferase ESA1/0.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.440
4gmy0X5Tyrosine-protein kinase JAK2/0.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440