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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5a8eXTKBeta-1 adrenergic receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5a8eXTKBeta-1 adrenergic receptor/1.000
4bvnP32Beta-1 adrenergic receptor/0.594
2ycxP32Beta-1 adrenergic receptor/0.593
2ycwCAUBeta-1 adrenergic receptor/0.586
4amjCVDBeta-1 adrenergic receptor/0.580
2rh1CAUBeta-2 adrenergic receptor/0.578
4amiG90Beta-1 adrenergic receptor/0.575
3ny8JRZBeta-2 adrenergic receptor/0.570
5d6lCAUBeta-2 adrenergic receptor/0.569
2yczI32Beta-1 adrenergic receptor/0.564
5jqhCAUBeta-2 adrenergic receptor/0.559
5d5bCAUBeta-2 adrenergic receptor/0.558
5d5aCAUBeta-2 adrenergic receptor/0.542
4gbrCAUBeta-2 adrenergic receptor/0.542
3ny9JSZBeta-2 adrenergic receptor/0.540
2y01Y00Beta-1 adrenergic receptor/0.539
3d4sTIMBeta-2 adrenergic receptor/0.532
2vt4P32Beta-1 adrenergic receptor/0.521
2ycyP32Beta-1 adrenergic receptor/0.520
2y035FWBeta-1 adrenergic receptor/0.517
2y02WHJBeta-1 adrenergic receptor/0.509
3nyaJTZBeta-2 adrenergic receptor/0.501
2y0468HBeta-1 adrenergic receptor/0.496
5f8uP32Beta-1 adrenergic receptor/0.487
4ldeP0GBeta-2 adrenergic receptor/0.483
4iarERM5-hydroxytryptamine receptor 1B/0.456
4ldlXQCBeta-2 adrenergic receptor/0.456