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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4z28BTNHoefavidin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4z28BTNHoefavidin/1.000
3ew2BTNHypothetical conserved protein/0.598
4bx7B4FStreptavidin/0.529
1mk5BTNStreptavidin/0.515
1i9hBNIStreptavidin/0.514
4gdaBTNStreptavidin/0.513
2izfBTNStreptavidin/0.508
1sreHABStreptavidin/0.504
1swtBTNStreptavidin/0.504
4dneDTBStreptavidin/0.504
3ry2BTNStreptavidin/0.503
1srgMHBStreptavidin/0.502
1stpBTNStreptavidin/0.497
2izhBTNStreptavidin/0.497
1df8BTNStreptavidin/0.495
2fhnBNIAvidin-related protein 4/5/0.490
2rtgBTNStreptavidin/0.489
2aviBTNAvidin/0.484
2rteBTNStreptavidin/0.484
2rtdBTNStreptavidin/0.483
1sriDMBStreptavidin/0.479
1srfMTBStreptavidin/0.478
2izlIMIStreptavidin/0.477
3wznBTNStreptavidin/0.476
2rtrIMIStreptavidin/0.474
1nqmBTNStreptavidin/0.472
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.471
1rxhBNIStreptavidin/0.470
2uz2BTNAvd protein/0.469
2rtfBTNStreptavidin/0.467
2rtqIMIStreptavidin/0.467
2uywBTNAvd protein/0.467
1swpBTQStreptavidin/0.465
2rtnIMIStreptavidin/0.465
2rtpIMIStreptavidin/0.464
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.463
3wyqBTNStreptavidin/0.462
1luqBTNStreptavidin/0.461
1lf3EH5Plasmepsin-23.4.23.390.459
1srhMOBStreptavidin/0.459
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.459
1srjNABStreptavidin/0.458
2fhlBNIAvidin-related protein 4/5/0.457
2izgBTNStreptavidin/0.454
2hq9FADMll6688 protein/0.453
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.453
3gwfFADCyclohexanone monooxygenase/0.451
3rdqDTBStreptavidin/0.451
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.450
1lcwSHMStreptavidin/0.450
2rtoIMIStreptavidin/0.450
3hz5Z64Heat shock protein HSP 90-alpha/0.450
1lczBH7Streptavidin/0.449
1swpBTNStreptavidin/0.449
2q4wFADCytokinin dehydrogenase 71.5.99.120.449
1nc9IMIStreptavidin/0.448
4bcsBTNAvidin-related protein 4/5/0.446
1s3uTQDDihydrofolate reductase1.5.1.30.445
1xe55FEPlasmepsin-23.4.23.390.445
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.445
4udqFAD5-(hydroxymethyl)furfural oxidase/0.445
4s0vSUVOrexin receptor type 2/0.445
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
2c4iBTNAvidin/0.443
3wfjNAD2-dehydropantoate 2-reductase/0.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
4ggzBTNBll1558 protein/0.443
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.443
3sn6P0GBeta-2 adrenergic receptor/0.443
3q44D50M1 family aminopeptidase3.4.110.442
4o71CPBBromodomain-containing protein 4/0.442
1sweBTNStreptavidin/0.441
5eccNAPDehydrofolate reductase type I/0.441
2xveFADPutative flavin-containing monooxygenase/0.440
2y3fBTNStreptavidin/0.440
3pqbVGPPutative oxidoreductase/0.440
4askK0ILysine-specific demethylase 6B1.14.110.440