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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.43

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.431.000
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.587
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.563
4ynpSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.539
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.490
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.459
3qfrFMNNADPH--cytochrome P450 reductase/0.444