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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4y93746Tyrosine-protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4y93746Tyrosine-protein kinase/1.000
4y95746Tyrosine-protein kinase/0.582
4j98ACPFibroblast growth factor receptor 2/0.473
4j99ACPFibroblast growth factor receptor 2/0.456
4j95ACPFibroblast growth factor receptor 2/0.455
3zewSTUEphrin type-B receptor 42.7.10.10.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.441