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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xvrGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xvrGNPGTPase HRas/1.000
1uadGNPRas-related protein Ral-A/0.579
4xvqGNPGTPase HRas/0.537
2rggGNPGTPase HRas/0.534
3tgpGNPGTPase HRas/0.529
4hdqGNPRas-related protein Rap-1b/0.524
1lfdGNPGTPase HRas/0.523
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.502
4lucGDPGTPase KRas/0.486
1zc4GNPRas-related protein Ral-A/0.477
1zc3GNPRas-related protein Ral-A/0.476
4tq9GDPGTPase KRas/0.476
4nyiGNPGTPase HRas/0.472
3cphGDPRas-related protein SEC4/0.471
3ddcGNPGTPase HRas/0.470
2fe4GDPRas-related protein Rab-6B/0.458
2c5lGTPGTPase HRas/0.457
3mjhGTPRas-related protein Rab-5A/0.456
2rgeGNPGTPase HRas/0.454
4qxaGTPRas-related protein Rab-9A/0.453
2cl6CAGGTPase HRas/0.451
3kkqGDPRas-related protein M-Ras/0.451
3oivGNPGTPase HRas/0.451
3kkoGNPRas-related protein M-Ras/0.450
4lpkGDPGTPase KRas/0.450
3pitGNPRas-related protein M-Ras/0.449
4epwGDPGTPase KRas/0.449
3v4fGNPGTPase HRas/0.443
3oesGNPGTPase RhebL1/0.440