sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4xvq | GNP | GTPase HRas |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4xvq | GNP | GTPase HRas | / | 1.000 | |
| 2rgg | GNP | GTPase HRas | / | 0.669 | |
| 3tgp | GNP | GTPase HRas | / | 0.654 | |
| 4xvr | GNP | GTPase HRas | / | 0.626 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.625 | |
| 1uad | GNP | Ras-related protein Ral-A | / | 0.609 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.564 | |
| 4lpk | GDP | GTPase KRas | / | 0.545 | |
| 2rge | GNP | GTPase HRas | / | 0.540 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.527 | |
| 4epw | GDP | GTPase KRas | / | 0.524 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.521 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.521 | |
| 4l8g | GDP | GTPase KRas | / | 0.518 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.517 | |
| 4l9s | GDP | GTPase HRas | / | 0.515 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.512 | |
| 2rgc | GNP | GTPase HRas | / | 0.506 | |
| 4luc | GDP | GTPase KRas | / | 0.504 | |
| 2ce2 | GDP | GTPase HRas | / | 0.499 | |
| 3ddc | GNP | GTPase HRas | / | 0.499 | |
| 4wa7 | GDP | GTPase KRas | / | 0.499 | |
| 3k9l | GNP | GTPase HRas | / | 0.498 | |
| 3k8y | GNP | GTPase HRas | / | 0.497 | |
| 2cl6 | CAG | GTPase HRas | / | 0.494 | |
| 4tq9 | GDP | GTPase KRas | / | 0.493 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.492 | |
| 3oiv | GNP | GTPase HRas | / | 0.491 | |
| 4nyi | GNP | GTPase HRas | / | 0.486 | |
| 3lbh | GNP | GTPase HRas | / | 0.482 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.482 | |
| 3v4f | GNP | GTPase HRas | / | 0.481 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.479 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.475 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.475 | |
| 4obe | GDP | GTPase KRas | / | 0.475 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.473 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.470 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.470 | |
| 1lfd | GNP | GTPase HRas | / | 0.469 | |
| 2c5l | GTP | GTPase HRas | / | 0.468 | |
| 4lrw | GDP | GTPase KRas | / | 0.468 | |
| 4q02 | GDP | GTPase KRas | / | 0.467 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.466 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.466 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.465 | |
| 4q03 | GDP | GTPase KRas | / | 0.465 | |
| 4ql3 | GDP | GTPase KRas | / | 0.465 | |
| 3i3s | GNP | GTPase HRas | / | 0.464 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.463 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.463 | |
| 4nyj | GNP | GTPase HRas | / | 0.461 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.460 | |
| 2ic5 | GNP | Ras-related C3 botulinum toxin substrate 3 | / | 0.459 | |
| 4epx | GDP | GTPase KRas | / | 0.459 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.457 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.456 | |
| 4lv6 | GDP | GTPase KRas | / | 0.456 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.455 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.455 | |
| 4ldj | GDP | GTPase KRas | / | 0.455 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.455 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.454 | |
| 3lbn | GNP | GTPase HRas | / | 0.453 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.451 | |
| 4dlt | GNP | GTPase HRas | / | 0.451 | |
| 2rgb | GNP | GTPase HRas | / | 0.450 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.450 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.449 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.449 | |
| 3oiu | GNP | GTPase HRas | / | 0.449 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.449 | |
| 4k81 | GTP | GTPase HRas | / | 0.449 | |
| 3rs5 | GNP | GTPase HRas | / | 0.448 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.447 | |
| 4dsn | GCP | GTPase KRas | / | 0.447 | |
| 4dsu | GDP | GTPase KRas | / | 0.447 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.446 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.446 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.446 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.444 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.444 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.444 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4d0l | GSP | Ras-related protein Rab-11A | / | 0.443 | |
| 4kq2 | U5P | Glycogen [starch] synthase isoform 2 | 2.4.1.11 | 0.443 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.441 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.440 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.440 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.440 |