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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xp1LDPSodium-dependent dopamine transporter

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xp1LDPSodium-dependent dopamine transporter/1.000
4xp4COCSodium-dependent dopamine transporter/0.611
4m4821BSodium-dependent dopamine transporter/0.603
4mmd29ENa(+):neurotransmitter symporter (Snf family)/0.562
4mme29QNa(+):neurotransmitter symporter (Snf family)/0.542
4mm48PRNa(+):neurotransmitter symporter (Snf family)/0.538
4mmc29JNa(+):neurotransmitter symporter (Snf family)/0.536
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.528
4mmf29QNa(+):neurotransmitter symporter (Snf family)/0.528
4mm9FVXNa(+):neurotransmitter symporter (Snf family)/0.523
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.477
1n2iPAJPantothenate synthetase6.3.2.10.466
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.461
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.461
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.455
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.450
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.450
1p0pBCHCholinesterase3.1.1.80.447
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.447
1xp6AIUEstrogen receptor/0.446
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.444
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.443
2nnqT4BFatty acid-binding protein, adipocyte/0.442
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.442
5jr34MUCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.442
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.441
3d2dRENReticuline oxidase1.21.3.30.441
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.441
3w0tHPULactoylglutathione lyase4.4.1.50.441
4ivqI43Thymidine kinase/0.441
3cow52HPantothenate synthetase6.3.2.10.440
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440