sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.555 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.554 | |
| 3cse | N22 | Uncharacterized protein | / | 0.547 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.543 | |
| 3eek | 53S | Uncharacterized protein | / | 0.540 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.539 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.538 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.536 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.536 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.535 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.535 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.532 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.531 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.526 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.514 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.511 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.508 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.502 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.501 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.500 | |
| 3eel | 53T | Uncharacterized protein | / | 0.499 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3eej | 53R | Uncharacterized protein | / | 0.498 | |
| 3eem | 53V | Uncharacterized protein | / | 0.498 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.490 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.488 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3qly | 55V | Uncharacterized protein | / | 0.487 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.486 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.486 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.484 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.480 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.477 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.472 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.471 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.466 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.463 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.461 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.461 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.457 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.456 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.456 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.456 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.455 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.455 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.454 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.449 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.448 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2ybo | SAH | Methyltransferase | / | 0.447 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.442 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.442 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 4l9q | 9TP | Serum albumin | / | 0.440 |