scPDB - Distribution of Binding site Similarity values of 4x5f entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4x5f	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	1.000
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.584
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.574
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.555
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.546
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.535
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.531
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.523
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.516
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.513
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.508
1ra2	FOL	Dihydrofolate reductase	1.5.1.3	0.506
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.506
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.504
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.503
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.502
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.499
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.496
5hi6	MTX	Dihydrofolate reductase	/	0.490
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.483
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.480
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.480
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.478
2w3v	TOP	Dihydrofolate reductase	/	0.477
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.476
3qlx	QLR	Uncharacterized protein	/	0.475
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.475
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.473
3cse	N22	Uncharacterized protein	/	0.473
3eem	53V	Uncharacterized protein	/	0.469
3qlz	QLZ	Uncharacterized protein	/	0.469
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.469
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.468
3sa1	6DR	Dihydrofolate reductase	/	0.468
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.465
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.465
3ia4	MTX	Dihydrofolate reductase	/	0.465
4fhb	FOL	Dihydrofolate reductase	1.5.1.3	0.465
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.464
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.464
2zza	FOL	Dihydrofolate reductase	/	0.462
3eej	53R	Uncharacterized protein	/	0.461
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.460
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.459
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.456
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.456
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.454
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3eek	53S	Uncharacterized protein	/	0.450
4h98	14Q	Uncharacterized protein	/	0.449
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.449
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.448
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.446
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.446
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.445
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.443
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.442
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.442
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.441
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.440