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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4wrkDUPDUTPase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4wrkDUPDUTPase/1.000
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.509
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.506
3t70DU4Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.502
2okeDUPDUTP pyrophosphatase/0.481
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.479
2we3DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase/0.473
2ol0DUDDUTP pyrophosphatase/0.472
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.469
2g247IGRenin3.4.23.150.466
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.460
4xfjANPArgininosuccinate synthase/0.455
1snfUMPDeoxyuridine 5'-triphosphate nucleotidohydrolase3.6.1.230.453
2y3rTRKTamL/0.449
2g1r3IGRenin3.4.23.150.444
2g226IGRenin3.4.23.150.441
3bk2U5PRibonuclease J/0.441
3iocA5DPantothenate synthetase6.3.2.10.441
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.440
5hg0SAMPantothenate synthetase/0.440