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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4qnyANPMitogen activated protein kinase, putative/0.517
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.492
4ysjADPCalmodulin-like domain protein kinase/0.489
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4eooATPCyclin-dependent kinase 22.7.11.220.478
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.471
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3c4zADPRhodopsin kinase/0.465
1qmzATPCyclin-dependent kinase 22.7.11.220.464
4crsAGSSerine/threonine-protein kinase N22.7.11.130.462
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4deeADPAurora kinase A2.7.11.10.461
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.460
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.454
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4ii5ADPCyclin-dependent kinase 22.7.11.220.449
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1ig1ANPDeath-associated protein kinase 12.7.11.10.447
4h3qANPMitogen-activated protein kinase 12.7.11.240.447
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2cciATPCyclin-dependent kinase 22.7.11.220.445
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
5dnrATPAurora kinase A2.7.11.10.444
3bu5ATPInsulin receptor2.7.10.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.441
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4xlvACPInsulin receptor2.7.10.10.441
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
5eg3ACPFibroblast growth factor receptor 2/0.440