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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/1.000
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.628
4tyj0LIFibroblast growth factor receptor 42.7.10.10.599
4uxq0LIFibroblast growth factor receptor 42.7.10.10.590
4nks2M2Fibroblast growth factor receptor 1/0.574
4qrc0LIFibroblast growth factor receptor 42.7.10.10.560
3oom507Activin receptor type-12.7.11.300.548
4gmy0X5Tyrosine-protein kinase JAK2/0.534
2z2w770Wee1-like protein kinase2.7.10.20.530
4fnyI3KALK tyrosine kinase receptor2.7.10.10.530
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.527
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.526
3cth319Hepatocyte growth factor receptor2.7.10.10.525
2j4z626Aurora kinase A2.7.11.10.515
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.514
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.511
3gxlQIGTGF-beta receptor type-12.7.11.300.510
4qmpDKISerine/threonine-protein kinase 242.7.11.10.510
3e5aVX6Aurora kinase A2.7.11.10.509
3biz61EWee1-like protein kinase2.7.10.20.508
4bgg844Activin receptor type-12.7.11.300.507
3js2VM1Fibroblast growth factor receptor 1/0.506
1fgiSU1Fibroblast growth factor receptor 1/0.504
3q5iANPProtein kinase, putative/0.504
4nka2K7Fibroblast growth factor receptor 1/0.504
3ctj320Hepatocyte growth factor receptor2.7.10.10.503
4aotGW8Serine/threonine-protein kinase 102.7.11.10.503
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.502
2y6o1N1Ephrin type-A receptor 42.7.10.10.502
4nk92K5Fibroblast growth factor receptor 1/0.499
1u4dDBQActivated CDC42 kinase 1/0.497
3tubFPUTyrosine-protein kinase SYK2.7.10.20.497
5e8xSTUTGF-beta receptor type-12.7.11.300.497
2hog710Serine/threonine-protein kinase Chk12.7.11.10.496
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.496
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.495
3cqeP91Wee1-like protein kinase2.7.10.20.495
4gg70J8Hepatocyte growth factor receptor2.7.10.10.495
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.494
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.494
3iw4LW4Protein kinase C alpha type2.7.11.130.494
2fgiPD1Fibroblast growth factor receptor 1/0.493
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.493
2qo9ANPEphrin type-A receptor 32.7.10.10.493
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.493
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.492
4j97ACPFibroblast growth factor receptor 2/0.492
2uzlC94Cyclin-dependent kinase 22.7.11.220.491
3mtfA3FActivin receptor type-12.7.11.300.491
4jia1K3Tyrosine-protein kinase JAK2/0.491
4jbqVX6Aurora kinase A2.7.11.10.489
1vjy460TGF-beta receptor type-12.7.11.300.488
3eta351Insulin receptor2.7.10.10.488
3bi6396Wee1-like protein kinase2.7.10.20.487
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.487
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.487
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.487
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.487
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.487
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4ele31IDihydrofolate reductase/0.486
4equG6ISerine/threonine-protein kinase 102.7.11.10.486
2in6839Wee1-like protein kinase2.7.10.20.485
2py3ACPFibroblast growth factor receptor 2/0.485
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.485
4qmzB49Serine/threonine-protein kinase 242.7.11.10.485
2pwlACPFibroblast growth factor receptor 2/0.484
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.484
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.484
2of4979Tyrosine-protein kinase Lck2.7.10.20.483
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.483
4k9yK9YFocal adhesion kinase 12.7.10.20.483
2xp2VGHALK tyrosine kinase receptor2.7.10.10.482
4af3VX6Aurora kinase B2.7.11.10.482
4hvh19RTyrosine-protein kinase JAK32.7.10.20.482
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.482
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.481
2ittAEEEpidermal growth factor receptor2.7.10.10.481
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.481
2pz5ACPFibroblast growth factor receptor 2/0.480
3be9P04Casein kinase II subunit alpha2.7.11.10.480
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.480
2itpAEEEpidermal growth factor receptor2.7.10.10.479
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.479
3bu5ATPInsulin receptor2.7.10.10.479
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.479
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.479
3zep1NXTyrosine-protein kinase JAK32.7.10.20.479
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.479
4lopSB4Mitogen-activated protein kinase 14/0.479
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.478
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.478
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.477
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.477
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.477
3zsgT75Mitogen-activated protein kinase 14/0.477
4b8mVX6Aurora kinase B-A2.7.11.10.477
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.477
4riyADPEpidermal growth factor receptor2.7.10.10.477
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.476
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.476
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.476
4i22IREEpidermal growth factor receptor2.7.10.10.476
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.476
4jlk1NODeoxycytidine kinase2.7.1.740.476
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
4wboANWRhodopsin kinase/0.476
2wpxACOOrf14/0.475
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.475
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.475
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.475
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.475
2excJNKMitogen-activated protein kinase 102.7.11.240.474
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.474
2nuaCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.474
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.474
4dymIYZActivin receptor type-12.7.11.300.474
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.474
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.474
1drbMTXDihydrofolate reductase1.5.1.30.473
2bakAQZMitogen-activated protein kinase 14/0.473
3dkoIHZEphrin type-A receptor 72.7.10.10.473
3l0lHC3Nuclear receptor ROR-gamma/0.473
3zeiAWHO-acetylserine sulfhydrylase/0.473
4a9yAQZMitogen-activated protein kinase 14/0.473
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.473
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
4grb0XGCasein kinase II subunit alpha2.7.11.10.473
4hni16WCasein kinase I isoform epsilon2.7.11.10.473
5e8wSTUTGF-beta receptor type-12.7.11.300.473
1jolFFODihydrofolate reductase1.5.1.30.472
1oecAA2Fibroblast growth factor receptor 2/0.472
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.472
2c6eHPMAurora kinase A2.7.11.10.472
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.472
2io6330Wee1-like protein kinase2.7.10.20.472
2xikJ60Serine/threonine-protein kinase 252.7.11.10.472
3f82353Hepatocyte growth factor receptor2.7.10.10.472
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.472
4kaoKAOFocal adhesion kinase 12.7.10.20.472
3t8oATPRhodopsin kinase/0.471
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.471
1fvv107Cyclin-dependent kinase 22.7.11.220.470
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.470
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.470
2ofv242Tyrosine-protein kinase Lck2.7.10.20.470
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.470
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3nga3NGCasein kinase II subunit alpha2.7.11.10.470
3s4qNK0Mitogen-activated protein kinase 14/0.470
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.470
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
3cr0809Wee1-like protein kinase2.7.10.20.469
3u4uLNHCasein kinase II subunit alpha2.7.11.10.469
3vrwYS5Vitamin D3 receptor/0.469
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.469
4cd2FOLDihydrofolate reductase1.5.1.30.469
4jboWPHAurora kinase A2.7.11.10.469
1xjdSTUProtein kinase C theta type2.7.11.130.468
3du8553Glycogen synthase kinase-3 beta2.7.11.260.468
3iaeD7KBenzaldehyde lyase/0.468
4c2wANPAurora kinase B-A2.7.11.10.468
4jlj1NMDeoxycytidine kinase2.7.1.740.468
4jr3KJREpidermal growth factor receptor2.7.10.10.468
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2q7vFADThioredoxin reductase/0.467
2vgpAD6Aurora kinase B-A2.7.11.10.467
2wouZZFTGF-beta receptor type-12.7.11.300.467
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.467
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.466
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.466
3owuEQUSteroid Delta-isomerase5.3.3.10.466
3vryB43Tyrosine-protein kinase HCK2.7.10.20.466
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.466
4f650S9Fibroblast growth factor receptor 1/0.466
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.466
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
4nieNBHNuclear receptor ROR-gamma/0.466
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.466
1jld0PPGag-Pol polyprotein/0.465
3drcMTXDihydrofolate reductase1.5.1.30.465
3kytHC2Nuclear receptor ROR-gamma/0.465
3l8p0CEAngiopoietin-1 receptor2.7.10.10.465
4ewqMWLMitogen-activated protein kinase 14/0.465
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.465
5dosATPAurora kinase A2.7.11.10.465
1pmn984Mitogen-activated protein kinase 102.7.11.240.464
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.464
2hk51BMTyrosine-protein kinase HCK2.7.10.20.464
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.464
2wkmPFYHepatocyte growth factor receptor2.7.10.10.464
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.464
3a7hATPSerine/threonine-protein kinase 242.7.11.10.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.464
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.464
3och2MXDihydrofolate reductase1.5.1.30.463
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.463
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.463
4dfrMTXDihydrofolate reductase1.5.1.30.463
4dgnLU2Casein kinase II subunit alpha2.7.11.10.463
1nq7ARLNuclear receptor ROR-beta/0.462
1ppjANYCytochrome b/0.462
2tscCB3Thymidylate synthase/0.462
2xa4AZ5Tyrosine-protein kinase JAK2/0.462
3mvl38PMitogen-activated protein kinase 14/0.462
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.462
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.462
3zsh469Mitogen-activated protein kinase 14/0.462
4c02TAKActivin receptor type-12.7.11.300.462
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.462
4e37NDPCatalase1.11.1.60.462
4gg50J3Hepatocyte growth factor receptor2.7.10.10.462
4j6bPLOCytochrome P450 monooxygenase/0.462
4jbpYPHAurora kinase A2.7.11.10.462
4jbtASDCytochrome P450 monooxygenase/0.462
4x5jFOLDihydrofolate reductase1.5.1.30.462
1ie8KH1Vitamin D3 receptor/0.461
1kceCB3Thymidylate synthase/0.461
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.461
2yac937Serine/threonine-protein kinase PLK12.7.11.210.461
3a4pDFQHepatocyte growth factor receptor2.7.10.10.461
3hllI45Mitogen-activated protein kinase 14/0.461
4g95OAGDihydrofolate reductase1.5.1.30.461
4j6dTESCytochrome P450 monooxygenase/0.461
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2po7CHDFerrochelatase, mitochondrial4.99.1.10.460
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.460
3fl8RARDihydrofolate reductase/0.460
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.460
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.460
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.460
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.459
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.459
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.459
3vt7VDXVitamin D3 receptor/0.459
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.459
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.459
4jqeANPCasein kinase II subunit alpha2.7.11.10.459
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.459
4yuqKS1Calmodulin-like domain protein kinase/0.459
1draMTXDihydrofolate reductase1.5.1.30.458
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.458
2igoFADPyranose 2-oxidase/0.458
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.458
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.458
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.458
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.458
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.458
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.458
4gk2L66Ephrin type-A receptor 32.7.10.10.458
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4nb6444Nuclear receptor ROR-gamma/0.458
5auwQUEDeath-associated protein kinase 12.7.11.10.458
1ywrLI9Mitogen-activated protein kinase 14/0.457
2i0ePDSProtein kinase C beta type2.7.11.130.457
2pzpACPFibroblast growth factor receptor 2/0.457
2qocANPEphrin type-A receptor 32.7.10.10.457
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.457
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.457
3bfb9ODPheromone-binding protein ASP1/0.457
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.457
3dt1P40Mitogen-activated protein kinase 14/0.457
3gu83GUDeath-associated protein kinase 12.7.11.10.457
3l6jZ90Alr2278 protein/0.457
3zh8C58Protein kinase C iota type2.7.11.130.457
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.457
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4e4m0NHTyrosine-protein kinase JAK2/0.457
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.457
5drdATPAurora kinase A2.7.11.10.457
1ol7ADPAurora kinase A2.7.11.10.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.456
3nww3NWMitogen-activated protein kinase 14/0.456
3rk507ZCyclin-dependent kinase 22.7.11.220.456
3ttjJBIMitogen-activated protein kinase 102.7.11.240.456
3vt8YI3Vitamin D3 receptor/0.456
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.456
4hvg19QTyrosine-protein kinase JAK32.7.10.20.456
1pkdUCNCyclin-dependent kinase 22.7.11.220.455
2itqITQEpidermal growth factor receptor2.7.10.10.455
2wotZZGTGF-beta receptor type-12.7.11.300.455
2x1nX1NCyclin-dependent kinase 22.7.11.220.455
3lfeZ84Mitogen-activated protein kinase 14/0.455
4elb34SDihydrofolate reductase/0.455
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.455
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.455
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.455
4fx360KCyclin-dependent kinase 22.7.11.220.455
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
1dajMOTDihydrofolate reductase1.5.1.30.454
2izrBRKCasein kinase I isoform gamma-32.7.11.10.454
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.454
2yn8STUEphrin type-B receptor 42.7.10.10.454
3b2tM33Fibroblast growth factor receptor 2/0.454
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.454
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.454
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3q9zTXQCasein kinase II subunit alpha2.7.11.10.454
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.454
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.454
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.454
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.453
2eufLQQCyclin-dependent kinase 62.7.11.220.453
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.453
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.453
3k5uPFQAurora kinase A2.7.11.10.453
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.453
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.453
4f630S7Fibroblast growth factor receptor 1/0.453
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.453
4wkqIREEpidermal growth factor receptor2.7.10.10.453
1r2jFADFkbI/0.452
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2dwbANPAurora kinase A2.7.11.10.452
2hm9TRRDihydrofolate reductase1.5.1.30.452
2jfz003Glutamate racemase/0.452
2zbzVDXVitamin D3 dihydroxylase/0.452
2zdt46CMitogen-activated protein kinase 102.7.11.240.452
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.452
3cv9VDXVitamin D3 dihydroxylase/0.452
3h0sB38Acetyl-CoA carboxylase/0.452
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.452
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
3zuyTCHTransporter/0.452
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.452
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.452
5dn3ATPAurora kinase A2.7.11.10.452
5hi6MTXDihydrofolate reductase/0.452
1ia4TQ6Dihydrofolate reductase1.5.1.30.451
1k1u0Q4Gag-Pol polyprotein3.4.23.160.451
1kl2FONSerine hydroxymethyltransferase/0.451
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.451
2of2547Tyrosine-protein kinase Lck2.7.10.20.451
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.451
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.451
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4f640S8Fibroblast growth factor receptor 1/0.451
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.451
4j6cSTRCytochrome P450 monooxygenase/0.451
4jq8KJ8Epidermal growth factor receptor2.7.10.10.451
4utdACPAurora kinase A2.7.11.10.451
5aacVGHALK tyrosine kinase receptor2.7.10.10.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
1re7FOLDihydrofolate reductase1.5.1.30.450
2itzIREEpidermal growth factor receptor2.7.10.10.450
2owb626Serine/threonine-protein kinase PLK12.7.11.210.450
3tucFPWTyrosine-protein kinase SYK2.7.10.20.450
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.450
4elb34RDihydrofolate reductase/0.450
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.450
4looSB4Mitogen-activated protein kinase 14/0.450
5bp9SAHPutative methyltransferase protein/0.450
1kijNOVDNA gyrase subunit B/0.449
1oc1ASVIsopenicillin N synthase1.21.3.10.449
2ftoCB3Thymidylate synthase/0.449
2h96893Mitogen-activated protein kinase 82.7.11.240.449
2j0j4STFocal adhesion kinase 12.7.10.20.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
2vx17X8Ephrin type-B receptor 42.7.10.10.449
2zjwREFCasein kinase II subunit alpha2.7.11.10.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3hl7I47Mitogen-activated protein kinase 14/0.449
3ocgOCGMitogen-activated protein kinase 14/0.449
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.449
3siiA1RUncharacterized protein/0.449
4b0gVEKAurora kinase A2.7.11.10.449
4c62XWWTyrosine-protein kinase JAK2/0.449
4elf35IDihydrofolate reductase/0.449
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.449
5cvhADPCasein kinase II subunit alpha2.7.11.10.449
1n83CLRNuclear receptor ROR-alpha/0.448
1pkfEPDEpothilone C/D epoxidase1.140.448
1u54ACPActivated CDC42 kinase 1/0.448
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.448
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.448
3atzFMNProstaglandin F2a synthase/0.448
3zs5SB2Mitogen-activated protein kinase 14/0.448
4agcAXIVascular endothelial growth factor receptor 22.7.10.10.448
4anqVGHALK tyrosine kinase receptor2.7.10.10.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4hge15VTyrosine-protein kinase JAK2/0.448
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.448
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
5f0a1FBcGMP-dependent protein kinase, putative/0.448
1lp4ANPCasein kinase II subunit alpha2.7.11.10.447
1metDMPGag-Pol polyprotein3.4.23.160.447
1pq944BOxysterols receptor LXR-beta/0.447
1rd7FOLDihydrofolate reductase1.5.1.30.447
1tdrMTXDihydrofolate reductase1.5.1.30.447
1zyjBI5Mitogen-activated protein kinase 14/0.447
1zys199Serine/threonine-protein kinase Chk12.7.11.10.447
2aclREARetinoic acid receptor RXR-alpha/0.447
2d29FADAcyl-CoA dehydrogenase/0.447
2dr3ADPUPF0273 protein PH0284/0.447
3ac1KZITyrosine-protein kinase Lck2.7.10.20.447
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.447
3id8MRKGlucokinase2.7.1.20.447
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.447
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
4h4m494Gag-Pol polyprotein2.7.7.490.447
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.447
5epeSAHUncharacterized protein/0.447
3qakUKAAdenosine receptor A2a/0.447
1hb3SCVIsopenicillin N synthase1.21.3.10.446
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.446
2j0k4STFocal adhesion kinase 12.7.10.20.446
2q61SF1Peroxisome proliferator-activated receptor gamma/0.446
3a60STURibosomal protein S6 kinase beta-12.7.11.10.446
3bgxMEFThymidylate synthase/0.446
3c1xCKKHepatocyte growth factor receptor2.7.10.10.446
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.446
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.446
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.446
3vquO22Dual specificity protein kinase TTK2.7.12.10.446
4aguD15Cyclin-dependent kinase-like 1/0.446
4b1fKRHGlutamate racemase/0.446
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.446
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.446
4v2gITCTetracycline repressor protein class D/0.446
4xldBRLPeroxisome proliferator-activated receptor gamma/0.446
1ia3TQ5Dihydrofolate reductase1.5.1.30.445
1m17AQ4Epidermal growth factor receptor2.7.10.10.445
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.445
2j0m4STFocal adhesion kinase 12.7.10.20.445
2oscMUHAngiopoietin-1 receptor2.7.10.10.445
2wpwACOOrf14/0.445
3p6oETGCamphor 5-monooxygenase1.14.15.10.445
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.445
3r8lZ30Cyclin-dependent kinase 22.7.11.220.445
3roc29AMitogen-activated protein kinase 14/0.445
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
3upjU03Gag-Pol polyprotein/0.445
3uwlFOZThymidylate synthase/0.445
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4fkr45KCyclin-dependent kinase 22.7.11.220.445
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.445
4jrvKJVEpidermal growth factor receptor2.7.10.10.445
5dr6SKEAurora kinase A2.7.11.10.445
1adfTADAlcohol dehydrogenase E chain1.1.1.10.444
1dhjMTXDihydrofolate reductase1.5.1.30.444
1hvyD16Thymidylate synthase2.1.1.450.444
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.444
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.444
1xp6AIUEstrogen receptor/0.444
2fzhDH1Dihydrofolate reductase1.5.1.30.444
2hw1ANPKetohexokinase/0.444
2p3c3TLProtease/0.444
2uxoTACHTH-type transcriptional regulator TtgR/0.444
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3h9f92MDual specificity protein kinase TTK2.7.12.10.444
3w18N13Aurora kinase A2.7.11.10.444
4bfxZVXPantothenate kinase2.7.1.330.444
4h4o506Gag-Pol polyprotein2.7.7.490.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4kfn1QRNicotinamide phosphoribosyltransferase2.4.2.120.444
1fm9570Peroxisome proliferator-activated receptor gamma/0.443
1om1IQACasein kinase II subunit alpha2.7.11.10.443
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.443
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.443
1rdtL79Retinoic acid receptor RXR-alpha/0.443
1uyePU9Heat shock protein HSP 90-alpha/0.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2d0kFOLDihydrofolate reductase1.5.1.30.443
2drcMTXDihydrofolate reductase1.5.1.30.443
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2qhxFE1Pteridine reductase 11.5.1.330.443
2rg5279Mitogen-activated protein kinase 14/0.443
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
2z3uCRRCytochrome P450/0.443
3abaFLICytochrome P450/0.443
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.443
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.443
3linE13Protease/0.443
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.443
3s79ASDAromatase1.14.14.140.443
3uleC69Actin-related protein 3/0.443
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.443
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.443
4dqc017Gag-Pol polyprotein/0.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
4j54G52Gag-Pol polyprotein3.4.23.160.443
4njt017Protease/0.443
1q5dEPBEpothilone C/D epoxidase1.140.442
1scuCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.442
1tg56454-hydroxyphenylpyruvate dioxygenase1.13.11.270.442
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.442
1yqj6NPMitogen-activated protein kinase 14/0.442
2d8aNADL-threonine 3-dehydrogenase/0.442
2etm7PYFocal adhesion kinase 12.7.10.20.442
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.442
2r0cFADPutative FAD-monooxygenase/0.442
2vgoAD5Aurora kinase B-A2.7.11.10.442
2vwz7X6Ephrin type-B receptor 42.7.10.10.442
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.442
4b66FADL-ornithine N(5)-monooxygenase/0.442
4blcNDPCatalase1.11.1.60.442
4dscA8SAbscisic acid receptor PYL3/0.442
5dr9SKEAurora kinase A2.7.11.10.442
5k2aZMAAdenosine receptor A2a/0.442
1dnaCB3Thymidylate synthase/0.441
1uy7PU4Heat shock protein HSP 90-alpha/0.441
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.441
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.441
2c3qGTXGlutathione S-transferase theta-12.5.1.180.441
2ewaSB2Mitogen-activated protein kinase 14/0.441
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.441
2idw017Protease/0.441
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.441
2qk8MTXDihydrofolate reductase/0.441
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.441
2xyuQ9GEphrin type-A receptor 42.7.10.10.441
3nszANPCasein kinase II subunit alpha2.7.11.10.441
3nwxKVSGag-Pol polyprotein3.4.23.160.441
3ogqAB1Pol polyprotein/0.441
3vtbTKAVitamin D3 receptor/0.441
4eevL1XHepatocyte growth factor receptor2.7.10.10.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4gevCB3Thymidylate synthase/0.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4qms1N1Serine/threonine-protein kinase 242.7.11.10.441
5aaaVGHALK tyrosine kinase receptor2.7.10.10.441
1blzACVIsopenicillin N synthase1.21.3.10.440
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
1yw2PGJMitogen-activated protein kinase 14/0.440
2cahNDPCatalase1.11.1.60.440
2iko7IGRenin3.4.23.150.440
2jedLG8Protein kinase C theta type2.7.11.130.440
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.440
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.440
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3datMTXDihydrofolate reductase/0.440
3fln3FNMitogen-activated protein kinase 14/0.440
3gfbNADL-threonine 3-dehydrogenase/0.440
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.440
3icrCOACoenzyme A disulfide reductase/0.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.440
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.440
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.440
4fko20KCyclin-dependent kinase 22.7.11.220.440
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.440
4ia2BIVVitamin D3 receptor A/0.440
4jazSTLPeroxisome proliferator-activated receptor gamma/0.440
4kip1R9Mitogen-activated protein kinase 14/0.440
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
5uviZMAAdenosine receptor A2a/0.440