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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4uxjTTPThymidine kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4uxjTTPThymidine kinase/1.000
2uz3TTPThymidine kinase/0.542
2b8tTHMThymidine kinase/0.475
1p4aPCPPur operon repressor/0.462
3qwbNDPProbable quinone oxidoreductase1.6.5.50.455
3v2uATPProtein GAL3/0.455
5fuwTHMThymidine kinase, putative/0.455
3gwfNAPCyclohexanone monooxygenase/0.454
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.452
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.449
2qo7ANPEphrin type-A receptor 32.7.10.10.449
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.449
3clrFADElectron transfer flavoprotein subunit alpha/0.447
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.447
2vwu7X1Ephrin type-B receptor 42.7.10.10.445
1ftlDNQGlutamate receptor 2/0.443
2r9eSDXCitrate synthase2.3.3.160.442
5kgpACOPredicted acetyltransferase/0.442
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
3cisATPUniversal stress protein Rv2623/0.440