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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4uunNAIL-lactate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4uunNAIL-lactate dehydrogenase/1.000
1wziNDPMalate dehydrogenase/0.576
2cvqNDPMalate dehydrogenase/0.556
1y7tNDPMalate dehydrogenase/0.550
2aa3AP0L-lactate dehydrogenase/0.529
1ur5NADMalate dehydrogenase/0.525
1guyNADMalate dehydrogenase/0.523
3wswNADL-lactate dehydrogenase/0.522
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.520
1bdmNAXMalate dehydrogenase/0.518
1b8vNADMalate dehydrogenase/0.515
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.509
1wzeNADMalate dehydrogenase/0.508
1uxkNADMalate dehydrogenase/0.501
2a92NAIL-lactate dehydrogenase/0.500
4i1iNADMalate dehydrogenase/0.498
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.494
2x0iNAIMalate dehydrogenase/0.494
1bmdNADMalate dehydrogenase/0.490
3gvhNADMalate dehydrogenase/0.490
3lqfNADGalactitol dehydrogenase/0.489
1ez4NADL-lactate dehydrogenase1.1.1.270.487
1gv0NADMalate dehydrogenase/0.484
1b8uNADMalate dehydrogenase/0.480
1llqNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.480
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.478
1ie3NADMalate dehydrogenase/0.478
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.478
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.478
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.475
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.473
3tjzGNPADP-ribosylation factor 1/0.473
3d4pNADL-lactate dehydrogenase 11.1.1.270.472
1uxjNADMalate dehydrogenase/0.471
4ambDUDPutative glycosyl transferase/0.471
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.470
1t2cNAIL-lactate dehydrogenase1.1.1.270.469
2a94AP0L-lactate dehydrogenase1.1.1.270.469
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.468
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.468
4ccqFADThioredoxin reductase/0.468
4q73FADBifunctional protein PutA/0.467
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.466
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.464
4acxS8ZBeta-secretase 13.4.23.460.464
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.463
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.463
5jscFADPutative acyl-CoA dehydrogenase/0.463
1ma0NADAlcohol dehydrogenase class-31.1.1.10.461
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.460
1psa0ZLPepsin A3.4.23.10.460
1tehNADAlcohol dehydrogenase class-31.1.1.10.460
2ebaFADPutative glutaryl-CoA dehydrogenase/0.460
3b6zCO7Enoyl reductase LovC10.460
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
3bg7FADPyranose 2-oxidase/0.459
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.459
2g8yNADHydroxycarboxylate dehydrogenase B/0.458
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.457
4qecNAPElxO/0.457
3hl0NADMaleylacetate reductase/0.456
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.456
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
2b3dFADModulator of drug activity B/0.455
2ignFADPyranose 2-oxidase/0.454
3c1y2BADNA integrity scanning protein DisA/0.454
2ahrNAPPyrroline-5-carboxylate reductase/0.453
2ft9CHDFatty acid-binding protein 2, liver/0.453
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.453
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.452
4k6fNAPPutative Acetoacetyl-CoA reductase/0.451
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.451
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.450
4m4922YL-lactate dehydrogenase A chain1.1.1.270.450
2iko7IGRenin3.4.23.150.449
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3mk6ACOPantothenate kinase 32.7.1.330.449
4ejvLCLTranscriptional regulator TcaR/0.449
4q71FADBifunctional protein PutA/0.449
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.448
3qlsNDPDihydrofolate reductase1.5.1.30.448
3to6LYS_CMCHistone acetyltransferase ESA1/0.448
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
5jlaNADPutative short-chain dehydrogenase/reductase/0.448
1gqtACPRibokinase/0.447
1xe55FEPlasmepsin-23.4.23.390.447
3gqvNAPEnoyl reductase LovC10.447
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.446
3b70NAPEnoyl reductase LovC10.446
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
3owaFADAcyl-CoA dehydrogenase/0.445
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
4rosAPRMalate dehydrogenase/0.444
5fm7ADPRuvB-like helicase/0.444
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.443
2ldbNADL-lactate dehydrogenase1.1.1.270.443
4gl4NAIAlcohol dehydrogenase class-3/0.443
5d3qGDPDynamin-13.6.5.50.443
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
3f1kNAPUncharacterized oxidoreductase YciK10.442
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.442
4z24FADPutative GMC-type oxidoreductase R13510.442
4z875GPInosine-5'-monophosphate dehydrogenase/0.442
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.441
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.441
2vkeTACTetracycline repressor protein class D/0.441
3ig6438Urokinase-type plasminogen activator3.4.21.730.441
3zpoK0IHistone demethylase UTY1.14.110.441
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.441
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1gcoNADGlucose 1-dehydrogenase1.1.1.470.440
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.440
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1xddAAYIntegrin alpha-L/0.440
1yb5NAPQuinone oxidoreductase1.6.5.50.440
2dc1NADProbable L-aspartate dehydrogenase/0.440
2fj1CTCTetracycline repressor protein class D/0.440
2ylrNAPPhenylacetone monooxygenase1.14.13.920.440
3hyoADPPyridoxal kinase/0.440
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.440