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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ugaH4BNitric oxide synthase oxygenase1.14.13.165

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ugaH4BNitric oxide synthase oxygenase1.14.13.1651.000
1qomH4BNitric oxide synthase, inducible1.14.13.390.651
1qw5H4BNitric oxide synthase, inducible1.14.13.390.647
3tymH4BNitric oxide synthase, brain1.14.13.390.636
4js9H4BNitric oxide synthase, inducible1.14.13.390.635
3e67H4BNitric oxide synthase, inducible1.14.13.390.634
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.633
3ufvH4BNitric oxide synthase, brain1.14.13.390.632
4cx3H4BNitric oxide synthase, brain1.14.13.390.632
1vafH4BNitric oxide synthase, inducible1.14.13.390.631
3e7iH4BNitric oxide synthase, inducible1.14.13.390.629
4ug7H4BNitric oxide synthase oxygenase1.14.13.1650.629
1p6kH4BNitric oxide synthase, brain1.14.13.390.623
1dwxH4BNitric oxide synthase, inducible1.14.13.390.622
3pngH4BNitric oxide synthase, brain1.14.13.390.620
4euxH4BNitric oxide synthase, brain1.14.13.390.616
4k5fH4BNitric oxide synthase, brain1.14.13.390.616
3rqjH4BNitric oxide synthase, brain1.14.13.390.615
4gqeH4BNitric oxide synthase, brain1.14.13.390.615
4jsfH4BNitric oxide synthase, brain1.14.13.390.615
4k5dH4BNitric oxide synthase, brain1.14.13.390.615
3b3pH4BNitric oxide synthase, brain1.14.13.390.613
1zzqH4BNitric oxide synthase, brain1.14.13.390.612
2nodH4BNitric oxide synthase, inducible1.14.13.390.612
3e6oH4BNitric oxide synthase, inducible1.14.13.390.612
3nljH4BNitric oxide synthase, brain1.14.13.390.610
1mjtNADNitric oxide synthase oxygenase/0.609
3jx4H4BNitric oxide synthase, brain1.14.13.390.609
3tylH4BNitric oxide synthase, brain1.14.13.390.609
4imtH4BNitric oxide synthase, brain1.14.13.390.609
3jx6H4BNitric oxide synthase, brain1.14.13.390.608
3b3mH4BNitric oxide synthase, brain1.14.13.390.607
4luxH4BNitric oxide synthase, brain1.14.13.390.607
3jx2H4BNitric oxide synthase, brain1.14.13.390.606
3nlnH4BNitric oxide synthase, brain1.14.13.390.606
3pneH4BNitric oxide synthase, brain1.14.13.390.606
3svqH4BNitric oxide synthase, brain1.14.13.390.606
4imwH4BNitric oxide synthase, brain1.14.13.390.605
3ufqH4BNitric oxide synthase, brain1.14.13.390.604
3e6tH4BNitric oxide synthase, inducible1.14.13.390.603
3jwtH4BNitric oxide synthase, brain1.14.13.390.603
3nlqH4BNitric oxide synthase, brain1.14.13.390.603
4k5eH4BNitric oxide synthase, brain1.14.13.390.603
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.603
1rs6H4BNitric oxide synthase, brain1.14.13.390.600
2hx3H4BNitric oxide synthase, brain1.14.13.390.600
3ej8H4BNitric oxide synthase, inducible1.14.13.390.600
3ufwH4BNitric oxide synthase, brain1.14.13.390.600
4fvzH4BNitric oxide synthase, brain1.14.13.390.600
3nlzH4BNitric oxide synthase, brain1.14.13.390.599
1k2tH4BNitric oxide synthase, brain1.14.13.390.598
3dwjH4BNitric oxide synthase, inducible1.14.13.390.598
3jx3H4BNitric oxide synthase, brain1.14.13.390.598
3n5vH4BNitric oxide synthase, brain1.14.13.390.598
3svpH4BNitric oxide synthase, brain1.14.13.390.598
4k5gH4BNitric oxide synthase, brain1.14.13.390.598
1m00H4BNitric oxide synthase, brain1.14.13.390.597
1zzuH4BNitric oxide synthase, brain1.14.13.390.596
3nnyH4BNitric oxide synthase, brain1.14.13.390.596
3nlwH4BNitric oxide synthase, brain1.14.13.390.595
4cx4H4BNitric oxide synthase, brain1.14.13.390.594
1zzrH4BNitric oxide synthase, brain1.14.13.390.593
3nlpH4BNitric oxide synthase, brain1.14.13.390.593
3rqmH4BNitric oxide synthase, brain1.14.13.390.593
4jsgH4BNitric oxide synthase, brain1.14.13.390.593
3jwvH4BNitric oxide synthase, brain1.14.13.390.591
3n5zH4BNitric oxide synthase, brain1.14.13.390.591
3nloH4BNitric oxide synthase, brain1.14.13.390.591
3e7gH4BNitric oxide synthase, inducible1.14.13.390.590
3jt4H4BNitric oxide synthase, brain1.14.13.390.590
3nlvH4BNitric oxide synthase, brain1.14.13.390.590
3pnfH4BNitric oxide synthase, brain1.14.13.390.590
3rqlH4BNitric oxide synthase, brain1.14.13.390.590
1p6jH4BNitric oxide synthase, brain1.14.13.390.588
3n5yH4BNitric oxide synthase, brain1.14.13.390.587
3b3nH4BNitric oxide synthase, brain1.14.13.390.586
4jshH4BNitric oxide synthase, brain1.14.13.390.586
1rs7H4BNitric oxide synthase, brain1.14.13.390.585
2hx4H4BNitric oxide synthase, brain1.14.13.390.585
3nlrH4BNitric oxide synthase, brain1.14.13.390.585
3q9aH4BNitric oxide synthase, brain1.14.13.390.585
3ufpH4BNitric oxide synthase, brain1.14.13.390.584
4cx5H4BNitric oxide synthase, brain1.14.13.390.584
3ufrH4BNitric oxide synthase, brain1.14.13.390.580
3b3oH4BNitric oxide synthase, brain1.14.13.390.579
3jt9H4BNitric oxide synthase, brain1.14.13.390.579
3ufoH4BNitric oxide synthase, brain1.14.13.390.579
3nlyH4BNitric oxide synthase, brain1.14.13.390.578
4fw0H4BNitric oxide synthase, brain1.14.13.390.578
5aglH4BNitric oxide synthase, brain1.14.13.390.576
3jtaH4BNitric oxide synthase, brain1.14.13.390.575
1k2uH4BNitric oxide synthase, brain1.14.13.390.574
3nlkH4BNitric oxide synthase, brain1.14.13.390.574
3nw2H4BNitric oxide synthase, inducible1.14.13.390.574
4ux6H4BNitric oxide synthase, inducible1.14.13.390.572
1m8iH4BNitric oxide synthase, inducible1.14.13.390.571
3rqkH4BNitric oxide synthase, brain1.14.13.390.569
3fc5H4BNitric oxide synthase, brain1.14.13.390.568
3dqrH4BNitric oxide synthase, brain1.14.13.390.566
3jx5H4BNitric oxide synthase, brain1.14.13.390.566
1m8dH4BNitric oxide synthase, inducible1.14.13.390.565
3nnzH4BNitric oxide synthase, brain1.14.13.390.565
1mmvH4BNitric oxide synthase, brain1.14.13.390.564
3jt7H4BNitric oxide synthase, brain1.14.13.390.564
3ufuH4BNitric oxide synthase, brain1.14.13.390.564
1m8eH4BNitric oxide synthase, inducible1.14.13.390.563
1m9tH4BNitric oxide synthase, inducible1.14.13.390.563
1r35H4BNitric oxide synthase, inducible1.14.13.390.562
2g6iHBINitric oxide synthase, brain1.14.13.390.561
2g6j7APNitric oxide synthase, brain1.14.13.390.561
3hsnH4BNitric oxide synthase, brain1.14.13.390.558
3q99H4BNitric oxide synthase, brain1.14.13.390.556
3jt5H4BNitric oxide synthase, brain1.14.13.390.555
3jt8H4BNitric oxide synthase, brain1.14.13.390.555
3jwuH4BNitric oxide synthase, brain1.14.13.390.554
3nodH4BNitric oxide synthase, inducible1.14.13.390.553
1m8hH4BNitric oxide synthase, inducible1.14.13.390.552
3ufsH4BNitric oxide synthase, brain1.14.13.390.552
4ug5H4BNitric oxide synthase oxygenase1.14.13.1650.552
4d1oH4BNitric oxide synthase, endothelial1.14.13.390.551
4jsiH4BNitric oxide synthase, brain1.14.13.390.549
3jt6H4BNitric oxide synthase, brain1.14.13.390.548
4fvyH4BNitric oxide synthase, brain1.14.13.390.546
3jt3H4BNitric oxide synthase, brain1.14.13.390.545
1zvlH4BNitric oxide synthase, brain1.14.13.390.543
4fvxH4BNitric oxide synthase, brain1.14.13.390.542
2y37H4BNitric oxide synthase, inducible1.14.13.390.539
5agkH4BNitric oxide synthase, brain1.14.13.390.534
1k2sH4BNitric oxide synthase, brain1.14.13.390.533
5agpH4BNitric oxide synthase, brain1.14.13.390.533
1om5H4BNitric oxide synthase, brain1.14.13.390.528
4imuH4BNitric oxide synthase, brain1.14.13.390.527
3nosH4BNitric oxide synthase, endothelial1.14.13.390.526
3uftH4BNitric oxide synthase, brain1.14.13.390.510
4jseH4BNitric oxide synthase, brain1.14.13.390.500
3juqAJDPhenazine biosynthesis protein A/B/0.496
4u0oMTALipoyl synthase 2/0.492
3n61H4BNitric oxide synthase, brain1.14.13.390.489
3h4vNAPPteridine reductase 11.5.1.330.485
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.484
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.484
3juqAKDPhenazine biosynthesis protein A/B/0.477
5ah5LSSLeucine--tRNA ligase/0.477
2dqmBESAminopeptidase N3.4.11.20.474
3af3GCPPantothenate kinase2.7.1.330.471
3n60XFNNitric oxide synthase, brain1.14.13.390.471
4fxy0W2Neurolysin, mitochondrial3.4.24.160.471
4f1yCNIGlutamate receptor 3/0.470
3adaNADSubunit alpha of sarocosine oxidase/0.469
3n66XFNNitric oxide synthase, brain1.14.13.390.462
2zseACPPantothenate kinase2.7.1.330.459
3junAJDPhenazine biosynthesis protein A/B/0.459
3pp1IZGDual specificity mitogen-activated protein kinase kinase 12.7.12.20.459
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.458
1zydATPeIF-2-alpha kinase GCN2/0.457
2geuCOKPantothenate kinase2.7.1.330.457
2o7oDXTTetracycline repressor protein class D/0.457
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.456
1esmCOAPantothenate kinase2.7.1.330.455
2gesCOKPantothenate kinase2.7.1.330.455
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.455
2getCOKPantothenate kinase2.7.1.330.454
1vjtNADAlpha-glucosidase, putative/0.453
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.451
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.451
3lnv1ZZSaframycin Mx1 synthetase B/0.451
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.451
1h48CDI2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.450
2hekGDPUncharacterized protein/0.450
2qcuFADAerobic glycerol-3-phosphate dehydrogenase1.1.5.30.450
3mx2TTPNucleoprotein/0.450
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.450
5fklTDCTetracycline repressor protein class D/0.450
3af2ACPPantothenate kinase2.7.1.330.449
3tm5SFGUncharacterized protein/0.448
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
1u80C5PCoenzyme A biosynthesis bifunctional protein CoaBC6.3.2.50.447
2zsaADPPantothenate kinase2.7.1.330.447
4dya0MFNucleoprotein/0.447
4k81GTPGTPase HRas/0.447
1y4lSVRBasic phospholipase A2 homolog 2/0.446
2vatCOAAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.446
2zsdCOAPantothenate kinase2.7.1.330.446
4rslFADFructosyl peptide oxidase/0.446
2hptBESAminopeptidase N3.4.11.20.445
3ustFADAcMNPV orf92/0.445
2vaxCSCAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.444
3q1kADPD-alanine--D-alanine ligase A6.3.2.40.444
4b8zGDPGDP-L-fucose synthase1.1.1.2710.444
4i3p1CW3-hydroxyanthranilate 3,4-dioxygenase/0.444
4kq1U5PGlycogen [starch] synthase/0.444
4xoiGTPTransforming protein RhoA/0.444
3af4GCPPantothenate kinase2.7.1.330.443
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.443
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.442
2e93B29Geranylgeranyl pyrophosphate synthase/0.442
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.442
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.442
3wstSAHProtein arginine N-methyltransferase 72.1.10.442
4n65FMNFMN-dependent NADH-azoreductase 1/0.442
4z36ON3Lysophosphatidic acid receptor 1/0.442
1ftlDNQGlutamate receptor 2/0.441
1g9cBABBotulinum neurotoxin type B3.4.24.690.441
1x2hLPALipoate-protein ligase A6.3.1.200.441
2bfoNDPPteridine reductase 11.5.1.330.441
3h03UBPGlutamate receptor 2/0.441
4f6s0SQCyclin-dependent kinase 82.7.11.220.441
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.441
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.440
1obnASVIsopenicillin N synthase1.21.3.10.440
4b3aTACTetracycline repressor protein class D/0.440
4bfsZVSPantothenate kinase2.7.1.330.440
4gncASORegucalcin3.1.1.170.440