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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ug7H4BNitric oxide synthase oxygenase1.14.13.165

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ug7H4BNitric oxide synthase oxygenase1.14.13.1651.000
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.724
4js9H4BNitric oxide synthase, inducible1.14.13.390.659
1qw5H4BNitric oxide synthase, inducible1.14.13.390.655
1qomH4BNitric oxide synthase, inducible1.14.13.390.646
3pngH4BNitric oxide synthase, brain1.14.13.390.635
1vafH4BNitric oxide synthase, inducible1.14.13.390.630
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.628
2hx3H4BNitric oxide synthase, brain1.14.13.390.626
4cx4H4BNitric oxide synthase, brain1.14.13.390.626
4fvzH4BNitric oxide synthase, brain1.14.13.390.625
4k5eH4BNitric oxide synthase, brain1.14.13.390.625
1zzuH4BNitric oxide synthase, brain1.14.13.390.624
4k5dH4BNitric oxide synthase, brain1.14.13.390.624
3dwjH4BNitric oxide synthase, inducible1.14.13.390.622
3nlvH4BNitric oxide synthase, brain1.14.13.390.622
1p6kH4BNitric oxide synthase, brain1.14.13.390.621
3n5yH4BNitric oxide synthase, brain1.14.13.390.621
1mjtNADNitric oxide synthase oxygenase/0.619
4imtH4BNitric oxide synthase, brain1.14.13.390.618
1p6jH4BNitric oxide synthase, brain1.14.13.390.617
3e7iH4BNitric oxide synthase, inducible1.14.13.390.617
3jwtH4BNitric oxide synthase, brain1.14.13.390.617
3nlzH4BNitric oxide synthase, brain1.14.13.390.617
3e6tH4BNitric oxide synthase, inducible1.14.13.390.615
3nlqH4BNitric oxide synthase, brain1.14.13.390.615
3nloH4BNitric oxide synthase, brain1.14.13.390.614
4jsfH4BNitric oxide synthase, brain1.14.13.390.614
3e6oH4BNitric oxide synthase, inducible1.14.13.390.613
3rqjH4BNitric oxide synthase, brain1.14.13.390.613
5aglH4BNitric oxide synthase, brain1.14.13.390.612
3nw2H4BNitric oxide synthase, inducible1.14.13.390.611
3pnfH4BNitric oxide synthase, brain1.14.13.390.611
4euxH4BNitric oxide synthase, brain1.14.13.390.611
3e67H4BNitric oxide synthase, inducible1.14.13.390.610
1zzqH4BNitric oxide synthase, brain1.14.13.390.609
3jwuH4BNitric oxide synthase, brain1.14.13.390.609
4k5gH4BNitric oxide synthase, brain1.14.13.390.609
3e7gH4BNitric oxide synthase, inducible1.14.13.390.608
3nlkH4BNitric oxide synthase, brain1.14.13.390.608
3nlnH4BNitric oxide synthase, brain1.14.13.390.608
4fw0H4BNitric oxide synthase, brain1.14.13.390.608
4jshH4BNitric oxide synthase, brain1.14.13.390.608
4cx5H4BNitric oxide synthase, brain1.14.13.390.607
4ugaH4BNitric oxide synthase oxygenase1.14.13.1650.607
4jsgH4BNitric oxide synthase, brain1.14.13.390.606
3nljH4BNitric oxide synthase, brain1.14.13.390.605
1m00H4BNitric oxide synthase, brain1.14.13.390.604
3n5vH4BNitric oxide synthase, brain1.14.13.390.603
4imwH4BNitric oxide synthase, brain1.14.13.390.603
3tymH4BNitric oxide synthase, brain1.14.13.390.602
3dqrH4BNitric oxide synthase, brain1.14.13.390.601
3nlrH4BNitric oxide synthase, brain1.14.13.390.601
3ufvH4BNitric oxide synthase, brain1.14.13.390.601
4gqeH4BNitric oxide synthase, brain1.14.13.390.600
1k2tH4BNitric oxide synthase, brain1.14.13.390.599
3nlpH4BNitric oxide synthase, brain1.14.13.390.599
3nlwH4BNitric oxide synthase, brain1.14.13.390.599
3ufrH4BNitric oxide synthase, brain1.14.13.390.599
3ej8H4BNitric oxide synthase, inducible1.14.13.390.598
3rqmH4BNitric oxide synthase, brain1.14.13.390.598
3b3pH4BNitric oxide synthase, brain1.14.13.390.597
3ufoH4BNitric oxide synthase, brain1.14.13.390.597
3jx2H4BNitric oxide synthase, brain1.14.13.390.596
1r35H4BNitric oxide synthase, inducible1.14.13.390.595
3tylH4BNitric oxide synthase, brain1.14.13.390.595
4k5fH4BNitric oxide synthase, brain1.14.13.390.595
3b3mH4BNitric oxide synthase, brain1.14.13.390.594
3jwvH4BNitric oxide synthase, brain1.14.13.390.594
3jx3H4BNitric oxide synthase, brain1.14.13.390.594
4cx3H4BNitric oxide synthase, brain1.14.13.390.594
2nodH4BNitric oxide synthase, inducible1.14.13.390.593
1k2uH4BNitric oxide synthase, brain1.14.13.390.592
3ufqH4BNitric oxide synthase, brain1.14.13.390.592
3jtaH4BNitric oxide synthase, brain1.14.13.390.591
4luxH4BNitric oxide synthase, brain1.14.13.390.591
1dwxH4BNitric oxide synthase, inducible1.14.13.390.590
1zzrH4BNitric oxide synthase, brain1.14.13.390.589
3n5zH4BNitric oxide synthase, brain1.14.13.390.588
4ug5H4BNitric oxide synthase oxygenase1.14.13.1650.587
5agkH4BNitric oxide synthase, brain1.14.13.390.586
3jt9H4BNitric oxide synthase, brain1.14.13.390.585
3jx4H4BNitric oxide synthase, brain1.14.13.390.585
3q9aH4BNitric oxide synthase, brain1.14.13.390.584
1zvlH4BNitric oxide synthase, brain1.14.13.390.583
3jx6H4BNitric oxide synthase, brain1.14.13.390.583
3b3oH4BNitric oxide synthase, brain1.14.13.390.582
3nodH4BNitric oxide synthase, inducible1.14.13.390.582
3jt7H4BNitric oxide synthase, brain1.14.13.390.581
3rqlH4BNitric oxide synthase, brain1.14.13.390.580
3ufuH4BNitric oxide synthase, brain1.14.13.390.580
2hx4H4BNitric oxide synthase, brain1.14.13.390.579
3jx5H4BNitric oxide synthase, brain1.14.13.390.578
1rs7H4BNitric oxide synthase, brain1.14.13.390.577
3fc5H4BNitric oxide synthase, brain1.14.13.390.576
3ufpH4BNitric oxide synthase, brain1.14.13.390.575
1rs6H4BNitric oxide synthase, brain1.14.13.390.574
3svpH4BNitric oxide synthase, brain1.14.13.390.574
5agpH4BNitric oxide synthase, brain1.14.13.390.573
3nlyH4BNitric oxide synthase, brain1.14.13.390.572
3pneH4BNitric oxide synthase, brain1.14.13.390.572
1m8dH4BNitric oxide synthase, inducible1.14.13.390.571
4jsiH4BNitric oxide synthase, brain1.14.13.390.571
2g6j7APNitric oxide synthase, brain1.14.13.390.570
3b3nH4BNitric oxide synthase, brain1.14.13.390.569
3jt8H4BNitric oxide synthase, brain1.14.13.390.569
3nnzH4BNitric oxide synthase, brain1.14.13.390.569
3ufwH4BNitric oxide synthase, brain1.14.13.390.569
1mmvH4BNitric oxide synthase, brain1.14.13.390.568
1m8eH4BNitric oxide synthase, inducible1.14.13.390.565
3jt4H4BNitric oxide synthase, brain1.14.13.390.565
1m8iH4BNitric oxide synthase, inducible1.14.13.390.562
3q99H4BNitric oxide synthase, brain1.14.13.390.562
4ux6H4BNitric oxide synthase, inducible1.14.13.390.562
3nnyH4BNitric oxide synthase, brain1.14.13.390.561
3jt5H4BNitric oxide synthase, brain1.14.13.390.560
4fvyH4BNitric oxide synthase, brain1.14.13.390.558
2g6iHBINitric oxide synthase, brain1.14.13.390.555
3rqkH4BNitric oxide synthase, brain1.14.13.390.555
3svqH4BNitric oxide synthase, brain1.14.13.390.553
3jt6H4BNitric oxide synthase, brain1.14.13.390.552
3nosH4BNitric oxide synthase, endothelial1.14.13.390.551
3jt3H4BNitric oxide synthase, brain1.14.13.390.546
3hsnH4BNitric oxide synthase, brain1.14.13.390.544
4d1oH4BNitric oxide synthase, endothelial1.14.13.390.544
3ufsH4BNitric oxide synthase, brain1.14.13.390.543
4fvxH4BNitric oxide synthase, brain1.14.13.390.541
1k2sH4BNitric oxide synthase, brain1.14.13.390.539
1m9tH4BNitric oxide synthase, inducible1.14.13.390.539
1om5H4BNitric oxide synthase, brain1.14.13.390.539
4jseH4BNitric oxide synthase, brain1.14.13.390.524
2y37H4BNitric oxide synthase, inducible1.14.13.390.522
3uftH4BNitric oxide synthase, brain1.14.13.390.513
1m8hH4BNitric oxide synthase, inducible1.14.13.390.506
1hfqMOTDihydrofolate reductase1.5.1.30.486
5ah5LSSLeucine--tRNA ligase/0.483
1g9bBABBotulinum neurotoxin type B3.4.24.690.480
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.476
3n61H4BNitric oxide synthase, brain1.14.13.390.474
2itpAEEEpidermal growth factor receptor2.7.10.10.469
1mo8ATPSodium/potassium-transporting ATPase subunit alpha-13.6.3.90.467
1vbmYSATyrosine--tRNA ligase6.1.1.10.464
1suwNAPNAD kinase/0.463
3q1kADPD-alanine--D-alanine ligase A6.3.2.40.463
4o4fATPKinase/0.463
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.462
1g9cBABBotulinum neurotoxin type B3.4.24.690.461
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.461
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.460
3n60XFNNitric oxide synthase, brain1.14.13.390.460
3wstSAHProtein arginine N-methyltransferase 72.1.10.460
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.460
4kq1U5PGlycogen [starch] synthase/0.460
2oz57XYUncharacterized protein/0.459
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.459
2zseACPPantothenate kinase2.7.1.330.458
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.456
3juqAJDPhenazine biosynthesis protein A/B/0.456
3n66XFNNitric oxide synthase, brain1.14.13.390.456
4dyp0MSNucleoprotein/0.456
4o4eATPKinase/0.455
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.455
1ftlDNQGlutamate receptor 2/0.454
1kruIPTGalactoside O-acetyltransferase2.3.1.180.454
5dc5B3NHistone deacetylase 83.5.1.980.454
3juqAKDPhenazine biosynthesis protein A/B/0.453
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.452
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
2mjpANPdITP/XTP pyrophosphatase3.6.1.190.452
2wn6NDPADP-ribosyltransferase enzymatic component/0.452
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.452
3af1GDPPantothenate kinase2.7.1.330.451
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.451
4u0oMTALipoyl synthase 2/0.451
2x9vTMQPteridine reductase/0.450
3fuhBESLeukotriene A-4 hydrolase3.3.2.60.450
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.450
3h03UBPGlutamate receptor 2/0.450
3h4vNAPPteridine reductase 11.5.1.330.450
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1xzqFONtRNA modification GTPase MnmE3.6.50.449
3af3GCPPantothenate kinase2.7.1.330.449
3i12ADPD-alanine--D-alanine ligase A6.3.2.40.449
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.449
4f1yCNIGlutamate receptor 3/0.448
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2vaxCSCAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.447
2ydxSTLMethionine adenosyltransferase 2 subunit beta/0.447
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.447
1xmmM7Gm7GpppX diphosphatase3.6.1.590.446
1yqj6NPMitogen-activated protein kinase 14/0.446
1zydATPeIF-2-alpha kinase GCN2/0.446
3rsv3RSBeta-secretase 13.4.23.460.446
3tm5SFGUncharacterized protein/0.446
4imuH4BNitric oxide synthase, brain1.14.13.390.445
1z0zNADNAD kinase/0.444
1g9aBABBotulinum neurotoxin type B3.4.24.690.443
3d8vUD1Bifunctional protein GlmU/0.443
4jrvKJVEpidermal growth factor receptor2.7.10.10.443
4oadCLMUncharacterized protein/0.443
2dqmBESAminopeptidase N3.4.11.20.442
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.442
3axbFADPutative oxidoreductase/0.442
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.442
4quvNDPDelta(14)-sterol reductase/0.442
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.442
3sn6P0GBeta-2 adrenergic receptor/0.442
2zsdCOAPantothenate kinase2.7.1.330.441
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.441
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.440
2chlDKICasein kinase I isoform gamma-32.7.11.10.440
2qcuFADAerobic glycerol-3-phosphate dehydrogenase1.1.5.30.440
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3l7lC2GTeichoic acid poly(glycerol phosphate) polymerase/0.440
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440