sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4u7w | NDP | MxaA |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4u7w | NDP | MxaA | / | 1.000 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.504 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.500 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.484 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.482 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.476 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.476 | |
| 4kwh | NAP | Reductase homolog | / | 0.475 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.471 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.469 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.468 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.467 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.464 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.464 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.464 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.462 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.461 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.460 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.459 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.459 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.457 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.456 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.453 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.453 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.452 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.451 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4qec | NAP | ElxO | / | 0.448 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.446 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.445 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.445 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.444 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.441 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.441 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.440 |