sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 1.000 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.624 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.596 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.588 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.577 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.546 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.545 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.542 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.537 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.536 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.533 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.526 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.525 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.520 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.511 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.510 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.510 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.508 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.502 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.501 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.501 | |
| 5amn | DTQ | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.501 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.499 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.499 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.499 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.497 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.496 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.495 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.494 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.493 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.493 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.491 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.491 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.490 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.490 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.489 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.487 | |
| 4agc | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.487 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.486 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.485 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.485 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.484 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.484 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.483 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.482 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.482 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.481 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.481 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.481 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.481 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.481 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.481 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.480 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.480 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.480 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.480 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.479 | |
| 2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.478 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.478 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.477 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.477 | |
| 3aba | FLI | Cytochrome P450 | / | 0.476 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.476 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.476 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.476 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.475 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.475 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.475 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.474 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.474 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.474 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.474 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.474 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.473 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.473 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.473 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.473 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.473 | |
| 3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.472 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.472 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.472 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.472 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.472 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.472 | |
| 4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.472 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.472 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.471 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.470 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.470 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.469 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.469 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.469 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.469 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.469 | |
| 4jbo | WPH | Aurora kinase A | 2.7.11.1 | 0.469 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.469 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.469 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.468 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.468 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.468 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.468 | |
| 4jbp | YPH | Aurora kinase A | 2.7.11.1 | 0.468 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.468 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.467 | |
| 2x2l | X2L | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.467 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.467 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.467 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.467 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.466 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.466 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.466 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.466 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.465 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.465 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.464 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.464 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.464 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.464 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.464 | |
| 4b1f | KRH | Glutamate racemase | / | 0.464 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.464 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.463 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.463 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.463 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.463 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.463 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.462 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.462 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.462 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.462 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.461 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.461 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.460 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.460 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.460 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3zsg | T75 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.460 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.459 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.459 | |
| 3htj | ET | EbrA repressor | / | 0.459 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.459 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.459 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.459 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.459 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.459 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.459 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.458 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.458 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.458 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.458 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.458 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.458 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.458 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.457 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.457 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.457 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.457 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.456 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.456 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.456 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4iae | 1DX | Alr2278 protein | / | 0.455 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.455 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.455 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.454 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.454 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.454 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.454 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.454 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.454 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.453 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 2xnn | 430 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.453 | |
| 1zdw | FLV | Prenyltransferase | / | 0.452 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.452 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.452 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.452 | |
| 4hvg | 19Q | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.452 | |
| 4y6g | F6F | Tryptophan synthase alpha chain | / | 0.452 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.451 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.451 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.451 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.451 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.451 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.451 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.451 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.451 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.451 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.451 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.450 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.450 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.450 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.449 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.449 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.449 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.449 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.449 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.449 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.449 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.449 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 3arv | SAU | Chitinase A | / | 0.448 | |
| 3gcp | SB2 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.448 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.448 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.448 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.448 | |
| 5dp2 | NAP | CurF | / | 0.448 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.447 | |
| 1syn | F89 | Thymidylate synthase | / | 0.447 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.447 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.447 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.447 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.446 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.446 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.446 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.446 | |
| 2wpx | ACO | Orf14 | / | 0.446 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.446 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3lu8 | IQX | Serum albumin | / | 0.446 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.446 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.446 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.446 | |
| 4g1w | G1W | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.446 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4la0 | 198 | Serum albumin | / | 0.446 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.445 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.445 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.445 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.445 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.445 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.445 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.445 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.445 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.444 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.444 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.444 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.444 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.444 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.444 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 5dpv | SKE | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 1kuv | CA5 | Serotonin N-acetyltransferase | / | 0.443 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.443 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.443 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.443 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.443 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.443 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.443 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.442 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.442 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.442 | |
| 3zux | TCH | Transporter | / | 0.442 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.442 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.442 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.442 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.442 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 1ppj | SMA | Cytochrome b | / | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.441 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.441 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.441 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4btk | DTQ | Tau-tubulin kinase 1 | 2.7.11.1 | 0.441 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.441 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.440 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.440 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.440 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.440 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.440 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4tqq | UQ1 | Reaction center protein L chain | / | 0.440 |