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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ttbFMNIodotyrosine deiodinase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ttbFMNIodotyrosine deiodinase 1/1.000
3to0FMNIodotyrosine deiodinase 11.21.1.10.660
3gh8FMNIodotyrosine deiodinase 11.21.1.10.591
3gfdFMNIodotyrosine deiodinase 11.21.1.10.558
4ttcFMNIodotyrosine deiodinase 1/0.556
3hj9FMNUncharacterized protein/0.488
1kqdFMNOxygen-insensitive NAD(P)H nitroreductase/0.483
3jv7NADSecondary alcohol dehydrogenase/0.478
3eo8FMNPutative nitroreductase/0.476
4a5lNDPThioredoxin reductase/0.475
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.470
2freFMNNAD(P)H-flavin oxidoreductase/0.470
3qdlFMNOxygen-insensitive NADPH nitroreductase/0.470
1p0hACOMycothiol acetyltransferase2.3.1.1890.467
3x22FMNOxygen-insensitive NAD(P)H nitroreductase/0.467
4opgFDAConserved Archaeal protein/0.464
1oonFMNOxygen-insensitive NAD(P)H nitroreductase/0.461
3pxvFMNNitroreductase/0.460
4awtFMNNADH:flavin oxidoreductase Sye1/0.459
4yqfGDPSeptin-9/0.459
1oo5FMNOxygen-insensitive NAD(P)H nitroreductase/0.458
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.457
1ykiFMNOxygen-insensitive NAD(P)H nitroreductase/0.457
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.455
1icvFMNOxygen-insensitive NAD(P)H nitroreductase/0.454
1ooqFMNOxygen-insensitive NAD(P)H nitroreductase/0.454
3junAKDPhenazine biosynthesis protein A/B/0.454
5idwNAPShort-chain dehydrogenase/reductase SDR/0.454
2q0kNAPThioredoxin reductase1.8.1.90.453
3jvvACPTwitching mobility protein/0.451
4opiFDAConserved Archaeal protein/0.451
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.450
3up5NAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.449
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/0.448
1njfADPDNA polymerase III subunit tau2.7.7.70.448
3x21FMNOxygen-insensitive NAD(P)H nitroreductase/0.448
4nesUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.448
1p9wANPType II secretion system protein E/0.446
1szgFNSCytochrome b2, mitochondrial1.1.2.30.446
3oz2FADDigeranylgeranylglycerophospholipid reductase/0.446
1ds7FMNOxygen-insensitive NAD(P)H nitroreductase/0.445
1kqbFMNOxygen-insensitive NAD(P)H nitroreductase/0.444
1ohhANPATP synthase subunit alpha, mitochondrial/0.443
1ohhANPATP synthase subunit beta, mitochondrial3.6.3.140.443
2gsdNADFormate dehydrogenase/0.443
3koqFMNPutative nitroreductase/0.443
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.443
2qo9ANPEphrin type-A receptor 32.7.10.10.442
3eofFMNPutative oxidase/0.442
3pduNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.442
1kqcFMNOxygen-insensitive NAD(P)H nitroreductase/0.441
1w5tANPORC1-type DNA replication protein 2/0.441
1yluFMNOxygen-insensitive NAD(P)H nitroreductase/0.441
2omeNADC-terminal-binding protein 2/0.441
2y4gTIRTamL/0.441
3lpkZ76Beta-secretase 13.4.23.460.441
4m5pFMNNADPH dehydrogenase/0.441
2geuCOKPantothenate kinase2.7.1.330.440
3nbvANPKetohexokinase/0.440
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.440