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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4tq9GDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4tq9GDPGTPase KRas/1.000
4l9sGDPGTPase HRas/0.613
4lucGDPGTPase KRas/0.613
2fe4GDPRas-related protein Rab-6B/0.592
3kkqGDPRas-related protein M-Ras/0.588
4lv6GDPGTPase KRas/0.588
4epwGDPGTPase KRas/0.587
4ql3GDPGTPase KRas/0.586
4q03GDPGTPase KRas/0.585
4epxGDPGTPase KRas/0.584
4obeGDPGTPase KRas/0.578
4xvrGNPGTPase HRas/0.578
4lpkGDPGTPase KRas/0.577
2rggGNPGTPase HRas/0.555
3ddcGNPGTPase HRas/0.555
4l8gGDPGTPase KRas/0.555
4q02GDPGTPase KRas/0.553
4wa7GDPGTPase KRas/0.550
4hdqGNPRas-related protein Rap-1b/0.549
3kkoGNPRas-related protein M-Ras/0.548
4nyiGNPGTPase HRas/0.547
4ldjGDPGTPase KRas/0.546
1uadGNPRas-related protein Ral-A/0.545
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.544
2fg5GNPRas-related protein Rab-31/0.540
1x1rGDPRas-related protein M-Ras/0.539
2ce2GDPGTPase HRas/0.539
3tgpGNPGTPase HRas/0.539
4o2rGDPGTP-binding protein Rheb/0.538
1lfdGNPGTPase HRas/0.537
3lbhGNPGTPase HRas/0.536
3l8yGNPGTPase HRas/0.535
3qbtGNPRas-related protein Rab-8A/0.535
3x1zGNPRas-related protein Rap-1b/0.535
1n6lGTPRas-related protein Rab-5A/0.533
3tsoGNPRas-related protein Rab-25/0.530
3v4fGNPGTPase HRas/0.530
3cphGDPRas-related protein SEC4/0.527
4xvqGNPGTPase HRas/0.525
4lrwGDPGTPase KRas/0.523
3i3sGNPGTPase HRas/0.520
3k9lGNPGTPase HRas/0.520
4nyjGNPGTPase HRas/0.520
3mjhGTPRas-related protein Rab-5A/0.519
1xtsGTPGTP-binding protein Rheb/0.518
3x1wGDPRas-related protein Rap-1b/0.518
4dsnGCPGTPase KRas/0.517
3pitGNPRas-related protein M-Ras/0.516
3oivGNPGTPase HRas/0.513
2c5lGTPGTPase HRas/0.511
4dltGNPGTPase HRas/0.511
5b2zGNPGTPase HRas/0.511
2rgcGNPGTPase HRas/0.509
3lbnGNPGTPase HRas/0.509
4g0nGNPGTPase HRas/0.509
2rgeGNPGTPase HRas/0.508
1zd9GDPADP-ribosylation factor-like protein 8A/0.507
3lbiGNPGTPase HRas/0.507
3rs4GNPGTPase HRas/0.507
4dsuGDPGTPase KRas/0.507
2rgbGNPGTPase HRas/0.506
2cl6CAGGTPase HRas/0.505
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.505
3rs0GNPGTPase HRas/0.504
3oiuGNPGTPase HRas/0.503
4dxaGSPRas-related protein Rap-1b/0.502
4k81GTPGTPase HRas/0.502
1tu3GNPRas-related protein Rab-5A/0.501
4uj3GNPRas-related protein Rab-11A/0.501
3kucGDPRas-related protein Rap-1A/0.499
4lhwGNPRas-related protein Rab-8A/0.499
4qxaGTPRas-related protein Rab-9A/0.499
1zc4GNPRas-related protein Ral-A/0.498
2bmeGNPRas-related protein Rab-4A/0.497
4mitGTPRho-related protein racC/0.497
1yu9GNPRas-related protein Rab-4A/0.496
1zc3GNPRas-related protein Ral-A/0.492
2mscGDPMHC class I alpha chain/0.491
5c46GSPRas-related protein Rab-11A/0.491
3k8yGNPGTPase HRas/0.490
3oiwGNPGTPase HRas/0.490
4dlzGNPGTPase HRas/0.488
1kmqGNPTransforming protein RhoA/0.487
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.487
5dhaGNPGTP-binding nuclear protein Ran/0.486
4dlsGNPGTPase HRas/0.484
3e5hGNPRas-related protein Rab-28/0.482
3oesGNPGTPase RhebL1/0.482
3vhxGTPADP-ribosylation factor 6/0.482
3kudGDPGTPase HRas/0.480
1yzqGNPRas-related protein Rab-6A/0.479
3rslGNPGTPase HRas/0.479
4hdoGNPRas-related protein Rap-1b/0.479
3rs5GNPGTPase HRas/0.478
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.474
4rkfGNPRas-related protein Rab-3/0.474
1g16GDPRas-related protein SEC4/0.473
3w3zGTPGTP-binding nuclear protein Ran/0.473
4o25GTPGTP-binding protein Rheb/0.473
1g17GNPRas-related protein SEC4/0.472
1oixGDPRas-related protein Rab-11A/0.472
1z0aGDPRas-related protein Rab-2A/0.472
1zbdGTPRas-related protein Rab-3A/0.472
4uj5GNPRas-related protein Rab-11A/0.472
2gilGTPRas-related protein Rab-6A/0.470
3rs7GNPGTPase HRas/0.470
4dlvGNPGTPase HRas/0.470
5difGNPGTP-binding nuclear protein Ran/0.470
4o2lGTPGTP-binding protein Rheb/0.469
1a2bGSPTransforming protein RhoA/0.468
4dlxGNPGTPase HRas/0.468
1z2aGDPRas-related protein Rab-23/0.467
4dlwGNPGTPase HRas/0.467
3rabGNPRas-related protein Rab-3A/0.466
3w2wATPCRISPR system Cmr subunit Cmr2/0.464
5jljGNPGTP-binding nuclear protein Ran/0.463
3pcrGTPADP-ribosylation factor 6/0.462
4kvgGTPRas-related protein Rap-1A/0.462
3a6pGTPGTP-binding nuclear protein Ran/0.461
1t91GTPRas-related protein Rab-7a/0.460
4dsoGSPGTPase KRas/0.459
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.458
1s1cGNPTransforming protein RhoA/0.457
1ibrGNPGTP-binding nuclear protein Ran/0.455
1e96GTPRas-related C3 botulinum toxin substrate 1/0.454
1xzqFONtRNA modification GTPase MnmE3.6.50.454
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.454
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.453
2q3fGNPRas-related GTP-binding protein D/0.453
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.453
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.452
5hpyGDPTransforming protein RhoA/0.452
2dftADPShikimate kinase2.7.1.710.451
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.451
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.451
3eg5GNPCell division control protein 42 homolog/0.451
4l9wGNPGTPase HRas/0.450
3bbpGTPRas-related protein Rab-6A/0.449
5iqiGNPBifunctional AAC/APH2.3.10.449
1d5cGDPGTPase (Rab6)/0.448
1ky2GNPGTP-binding protein YPT7/0.448
3lawGNPRas-related protein Rab-7a/0.448
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.448
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.447
1v8kANPKinesin-like protein KIF2C/0.445
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.444
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.443
2zetGTPRas-related protein Rab-27B/0.443
3a58GNPGTP-binding protein RHO1/0.443
4wbnGTPTubulin alpha-1B chain/0.443
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.442
3t1tGDPProbable gliding protein mglA/0.442
1xtrGNPGTP-binding protein Rheb/0.441
4q71FADBifunctional protein PutA/0.441
1am4GNPCell division control protein 42 homolog/0.440
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.440
3ea5GDPGTP-binding nuclear protein Ran/0.440
3th5GNPRas-related C3 botulinum toxin substrate 1/0.440