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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4stdBFSScytalone dehydratase4.2.1.94

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4stdBFSScytalone dehydratase4.2.1.941.000
5stdUNNScytalone dehydratase4.2.1.940.630
6stdMS2Scytalone dehydratase4.2.1.940.623
7stdCRPScytalone dehydratase4.2.1.940.621
3stdMQ0Scytalone dehydratase4.2.1.940.596
2stdCRPScytalone dehydratase4.2.1.940.579
1stdBFSScytalone dehydratase4.2.1.940.563
3zkyWT4Isopenicillin N synthase1.21.3.10.551
1oc1ASVIsopenicillin N synthase1.21.3.10.533
2vbpVB1Isopenicillin N synthase1.21.3.10.531
2bu9HFVIsopenicillin N synthase1.21.3.10.522
2y60M8FIsopenicillin N synthase1.21.3.10.522
1qjfACSIsopenicillin N synthase1.21.3.10.517
4iae1DXAlr2278 protein/0.517
1obnASVIsopenicillin N synthase1.21.3.10.516
1qiqACCIsopenicillin N synthase1.21.3.10.516
3h3qH13Collagen type IV alpha-3-binding protein/0.515
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.513
2vbdV10Isopenicillin N synthase1.21.3.10.513
2wo7ASVIsopenicillin N synthase1.21.3.10.513
1blzACVIsopenicillin N synthase1.21.3.10.509
1ygjRMCPyridoxal kinase2.7.1.350.509
2mm3CHOGastrotropin/0.508
2vcmM11Isopenicillin N synthase1.21.3.10.508
1el4CTZObelin/0.504
3zoiM2WIsopenicillin N synthase1.21.3.10.503
1hb3SCVIsopenicillin N synthase1.21.3.10.501
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.500
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.499
1qv1CZHObelin/0.498
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.497
4bfxZVXPantothenate kinase2.7.1.330.495
1hb1OCVIsopenicillin N synthase1.21.3.10.494
1b2lNDCAlcohol dehydrogenase1.1.1.10.493
3pqbVGPPutative oxidoreductase/0.493
4cdmFO1Deoxyribodipyrimidine photolyase/0.493
4c717RD3-oxoacyl-ACP synthase/0.492
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.491
4bfvZVVPantothenate kinase2.7.1.330.491
2jb4A14Isopenicillin N synthase1.21.3.10.490
3iktNADRedox-sensing transcriptional repressor Rex/0.490
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.490
1u1f183Uridine phosphorylase2.4.2.30.489
1uzwCDHIsopenicillin N synthase1.21.3.10.489
4iah1DXAlr2278 protein/0.489
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.488
1uhhCZPAequorin-2/0.488
4jqh1MFAlr2278 protein/0.488
4bb3KKAIsopenicillin N synthase1.21.3.10.487
1dghNDPCatalase1.11.1.60.486
1pqc444Oxysterols receptor LXR-beta/0.486
1s7gNADNAD-dependent protein deacylase 2/0.486
3h3t16HCollagen type IV alpha-3-binding protein/0.486
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.485
2uxoTACHTH-type transcriptional regulator TtgR/0.485
3gncQQQGlutaryl-CoA dehydrogenase/0.485
1xddAAYIntegrin alpha-L/0.484
2iviACWIsopenicillin N synthase1.21.3.10.484
4k4eK4ETankyrase-12.4.2.300.484
4l5b1UXDeoxycytidine kinase2.7.1.740.484
4psbGA3Cytokinin-specific binding protein/0.484
1ygkRRCPyridoxal kinase2.7.1.350.483
2vqqTFGHistone deacetylase 43.5.1.980.483
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.483
3s3vTOPDihydrofolate reductase1.5.1.30.483
1hfqMOTDihydrofolate reductase1.5.1.30.482
1jf0CZHObelin/0.482
1mtcGPRGlutathione S-transferase Mu 12.5.1.180.482
2hxzH7JCathepsin S3.4.22.270.482
1yc2NADNAD-dependent protein deacylase 2/0.481
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.481
4ggzBTNBll1558 protein/0.481
1upw444Oxysterols receptor LXR-beta/0.480
2y6fM9FIsopenicillin N synthase1.21.3.10.480
1toiHCIAspartate aminotransferase2.6.1.10.479
1x8lOXRRetinol dehydratase/0.479
1yhjR6CPyridoxal kinase2.7.1.350.479
1yw8A75Methionine aminopeptidase 2/0.479
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.479
4e37NDPCatalase1.11.1.60.479
4j6dTESCytochrome P450 monooxygenase/0.479
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.478
2dhfDZFDihydrofolate reductase1.5.1.30.478
2yatEEUEstrogen receptor/0.478
4dvi2IWTankyrase-12.4.2.300.478
4jlj1NMDeoxycytidine kinase2.7.1.740.478
4k4fK4FTankyrase-12.4.2.300.478
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.477
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.477
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.476
1qv0CZHObelin/0.476
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
3nmpPYVAbscisic acid receptor PYL2/0.476
4kbyC2EStimulator of interferon genes protein/0.476
1jf2CZHObelin/0.475
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.475
3njoPYVAbscisic acid receptor PYR1/0.475
4boeCLRJapanin/0.475
7catNDPCatalase1.11.1.60.475
1u0wSTLChalcone synthase 22.3.1.740.474
1zdwFLVPrenyltransferase/0.474
2bjsACVIsopenicillin N synthase1.21.3.10.474
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.474
4n4t2GVTankyrase-12.4.2.300.474
1dr4HBIDihydrofolate reductase1.5.1.30.473
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.473
2po7CHDFerrochelatase, mitochondrial4.99.1.10.473
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
3h3r14HCollagen type IV alpha-3-binding protein/0.473
3l6jZ90Alr2278 protein/0.473
3mjrAC2Deoxycytidine kinase2.7.1.740.473
3nwlNDPCatalase1.11.1.60.473
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.473
4jyzATPGlutamine--tRNA ligase6.1.1.180.473
4u163C0Muscarinic acetylcholine receptor M3/0.473
3qeoLLTDeoxycytidine kinase2.7.1.740.472
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.472
4jlm1NNDeoxycytidine kinase2.7.1.740.472
1klkPMDDihydrofolate reductase1.5.1.30.471
1w06W05Isopenicillin N synthase1.21.3.10.471
1w6jR71Lanosterol synthase5.4.99.70.471
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.471
3gyf51PDihydrofolate reductase1.5.1.30.471
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.470
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1vf3GDNGlutathione S-transferase 32.5.1.180.470
3rsv3RSBeta-secretase 13.4.23.460.470
1icqOPD12-oxophytodienoate reductase 11.3.1.420.469
1pq944BOxysterols receptor LXR-beta/0.469
2ejzSAHDiphthine synthase/0.469
4dch4DCGlucokinase2.7.1.20.469
4n4v2GYTankyrase-12.4.2.300.469
4nqgCZHMitrocomin/0.469
1drfFOLDihydrofolate reductase1.5.1.30.468
1txtCAAHMG-CoA synthase/0.468
1vgrCOAFormyl-CoA:oxalate CoA-transferase/0.468
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.468
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.468
4p9dTMPDeoxycytidylate deaminase/0.468
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.468
4twnB96Ephrin type-A receptor 32.7.10.10.468
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.468
1gt5BZQOdorant-binding protein/0.467
1s3uTQDDihydrofolate reductase1.5.1.30.467
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.467
1thz326Bifunctional purine biosynthesis protein PURH2.1.2.30.467
1yw7A41Methionine aminopeptidase 2/0.467
3nu03TUDihydrofolate reductase1.5.1.30.467
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.467
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.467
4bfwZVWPantothenate kinase2.7.1.330.467
4dbw511Aldo-keto reductase family 1 member C3/0.467
8catNDPCatalase1.11.1.60.467
2cekN8TAcetylcholinesterase3.1.1.70.466
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.466
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.466
3p0fBAUUridine phosphorylase 22.4.2.30.466
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.466
3zkuHCVIsopenicillin N synthase1.21.3.10.466
4jln18VDeoxycytidine kinase2.7.1.740.466
1pd9CO4Dihydrofolate reductase1.5.1.30.465
1u1cBAUUridine phosphorylase2.4.2.30.465
2gv8NDPThiol-specific monooxygenase1.14.130.465
3c3xNAPEugenol synthase 11.1.1.3180.465
3ihgVAKAklavinone 12-hydroxylase RdmE/0.465
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4kebFOLDihydrofolate reductase1.5.1.30.465
4n1fCZHObelin/0.465
4s1iPLPPyridoxal kinase, putative/0.465
4xoqF42Coenzyme F420:L-glutamate ligase/0.465
1bk0ACVIsopenicillin N synthase1.21.3.10.464
1hfrMOTDihydrofolate reductase1.5.1.30.464
1i05LTLMajor urinary protein 6/0.464
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.464
2nm2NEUDihydroneopterin aldolase/0.464
3c1oNAPEugenol synthase/0.464
3dlaNXXGlutamine-dependent NAD(+) synthetase6.3.5.10.464
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4bquCLRJapanin/0.464
4mt92D6Tankyrase-12.4.2.300.464
1dggNDPCatalase1.11.1.60.463
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.463
2fs4PZ1Renin3.4.23.150.463
2pdlTOLAldose reductase1.1.1.210.463
2xlsFADPutative flavin-containing monooxygenase/0.463
3bl7DD1m7GpppX diphosphatase3.6.1.590.463
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3nxyD2HDihydrofolate reductase1.5.1.30.463
3v94WYQPhosphodiesterase/0.463
5agyGTBTau class glutathione S-transferase/0.463
1ohkCOPDihydrofolate reductase1.5.1.30.462
1qorNDPQuinone oxidoreductase 1/0.462
1rftPXMPyridoxal kinase2.7.1.350.462
2yg3FADPutrescine oxidase/0.462
3ekuCY9Actin-5C/0.462
3k4551PDihydrofolate reductase1.5.1.30.462
3nxtD2EDihydrofolate reductase1.5.1.30.462
4bj9UHBTankyrase-22.4.2.300.462
4li81XQTankyrase-12.4.2.300.462
5c1mCLRMu-type opioid receptor/0.462
5dp2NAPCurF/0.462
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.462
3rfmCFFAdenosine receptor A2a/0.462
1dgbNDPCatalase1.11.1.60.461
1dgfNDPCatalase1.11.1.60.461
1dliUDXUDP-glucose 6-dehydrogenase/0.461
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.461
1q23FUAChloramphenicol acetyltransferase2.3.1.280.461
2pnuENMAndrogen receptor/0.461
2zevB71Geranylgeranyl pyrophosphate synthase/0.461
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.461
4ddrMMVDihydrofolate reductase1.5.1.30.461
4kfjFOLDihydrofolate reductase1.5.1.30.461
4qa0SHHHistone deacetylase 83.5.1.980.461
1mvtDTMDihydrofolate reductase1.5.1.30.460
1nm6L86Prothrombin3.4.21.50.460
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.460
2tplHPPTyrosine phenol-lyase4.1.99.20.460
3aosJH2Hemolymph juvenile hormone binding protein/0.460
3h3sH15Collagen type IV alpha-3-binding protein/0.460
3rgzBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.460
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.460
4dbc3QPAspartate aminotransferase2.6.1.10.460
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.460
4u140HKMuscarinic acetylcholine receptor M3/0.460
3emlZMAAdenosine receptor A2a/0.460
1dhfFOLDihydrofolate reductase1.5.1.30.459
1kmsLIHDihydrofolate reductase1.5.1.30.459
1s36CEIObelin/0.459
2ed3SAHDiphthine synthase/0.459
2uxpCLMHTH-type transcriptional regulator TtgR/0.459
3a1l2CCCytochrome P450/0.459
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3eufBAUUridine phosphorylase 1/0.459
3f0aACOSpermidine N(1)-acetyltransferase/0.459
3hk1B64Fatty acid-binding protein, adipocyte/0.459
3p0eBAUUridine phosphorylase 22.4.2.30.459
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.459
4b2gV1NUncharacterized protein/0.459
4bftZVTPantothenate kinase2.7.1.330.459
5dozNDPJamJ/0.459
1n9mBTNStreptavidin/0.458
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.458
3dcsMZMCarbonic anhydrase 24.2.1.10.458
3f3y4OABile salt sulfotransferase2.8.2.140.458
3sl2ATPSensor histidine kinase WalK/0.458
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.458
1d3pBT3Prothrombin3.4.21.50.457
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.457
2h94FADLysine-specific histone demethylase 1A10.457
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.457
3br3ETHTH-type transcriptional regulator QacR/0.457
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.457
4o701QKBromodomain-containing protein 4/0.457
4tkg09LTankyrase-22.4.2.300.457
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.456
1muuGDXGDP-mannose 6-dehydrogenase1.1.1.1320.456
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.456
3anmSYD1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.456
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4bfuZVUPantothenate kinase2.7.1.330.456
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
4j6cSTRCytochrome P450 monooxygenase/0.456
4jq4IMNAldo-keto reductase family 1 member C2/0.456
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.456
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
1n43BTNStreptavidin/0.455
1odcA8BAcetylcholinesterase3.1.1.70.455
1touB1VFatty acid-binding protein, adipocyte/0.455
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
2f3815MAldo-keto reductase family 1 member C3/0.455
2p15EZTEstrogen receptor/0.455
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.455
2x9dITCTetracycline repressor protein class D/0.455
2xujTZ5Acetylcholinesterase3.1.1.70.455
2z1qFADAcyl-CoA dehydrogenase/0.455
3djfBC3Purine nucleoside phosphorylase/0.455
3g6zA7TRenin3.4.23.150.455
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3s41S41Glucokinase2.7.1.20.455
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.455
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4kbn25UDihydrofolate reductase1.5.1.30.455
4lzwTHMUridine phosphorylase/0.455
4tyqAP5Adenylate kinase/0.455
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.454
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.454
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.454
1ohjCOPDihydrofolate reductase1.5.1.30.454
1uhjCZBAequorin-2/0.454
1w87FADFerredoxin--NADP reductase1.18.1.20.454
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
2qw8NAPEugenol synthase 11.1.1.3180.454
2x7hPFNProstaglandin reductase 310.454
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
2yj4ATPCopper-transporting ATPase/0.454
2z4sADPChromosomal replication initiator protein DnaA/0.454
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.454
3eksCY9Actin-5C/0.454
3jynNDPQuinone oxidoreductase/0.454
3ojxFMNNADPH--cytochrome P450 reductase/0.454
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.454
4daj0HKMuscarinic acetylcholine receptor M3/0.454
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.453
1jdzFMBPurine nucleoside phosphorylase/0.453
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.453
1swnBTNStreptavidin/0.453
1thnADPAnti-sigma F factor/0.453
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.453
2fl2ADPKinesin-like protein KIF11/0.453
2pgtGPRGlutathione S-transferase P2.5.1.180.453
2rlcCHDCholoylglycine hydrolase3.5.1.240.453
3akm11DFatty acid-binding protein, intestinal/0.453
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3ipq965Oxysterols receptor LXR-alpha/0.453
3n0hTOPDihydrofolate reductase1.5.1.30.453
3wv9FEGHmd co-occurring protein HcgE/0.453
4bfzZVZPantothenate kinase2.7.1.330.453
4c6zTLE3-oxoacyl-ACP synthase/0.453
4g8cC6LAlpha/beta hydrolase fold protein/0.453
4i5xFLFAldo-keto reductase family 1 member B101.1.10.453
4jv41ORcAMP-dependent protein kinase type I-alpha regulatory subunit/0.453
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
4uugPXGBranched-chain amino acid aminotransferase, putative/0.453
4xp1LDPSodium-dependent dopamine transporter/0.453
5liu388Aldo-keto reductase family 1 member B101.1.10.453
5g53NECAdenosine receptor A2a/0.453
1d3dBZTProthrombin3.4.21.50.452
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
1rxjBNIStreptavidin/0.452
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.452
1xs7MMIBeta-secretase 13.4.23.460.452
1yryMSGPurine nucleoside phosphorylase2.4.2.10.452
2qryTPSThiamine-binding periplasmic protein/0.452
2vezACOGlucosamine 6-phosphate acetyltransferase, putative/0.452
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.452
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4dbs0HVAldo-keto reductase family 1 member C3/0.452
4eqrCOACoenzyme A disulfide reductase/0.452
4fa30SLAldo-keto reductase family 1 member C3/0.452
4msg2C6Tankyrase-12.4.2.300.452
1c7oPPGHemolysin/0.451
1mczRMNBenzoylformate decarboxylase4.1.1.70.451
1p8dCO1Oxysterols receptor LXR-beta/0.451
1rc4DDFDihydrofolate reductase1.5.1.30.451
1rpwDIDHTH-type transcriptional regulator QacR/0.451
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.451
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2j3qTFLAcetylcholinesterase3.1.1.70.451
2ym1FADPhenylacetone monooxygenase1.14.13.920.451
3iogSDFMetallo-beta-lactamase type 2/0.451
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.451
4bmpFMNProtein NrdI/0.451
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.451
4qa2SHHHistone deacetylase 83.5.1.980.451
1eiiRTLRetinol-binding protein 2/0.450
1lnmDTXBilin-binding protein/0.450
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.450
1qrsATPGlutamine--tRNA ligase6.1.1.180.450
1u65CP0Acetylcholinesterase3.1.1.70.450
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.450
2ga2A19Methionine aminopeptidase 2/0.450
2gevCOKPantothenate kinase2.7.1.330.450
2hcdBIVVitamin D3 receptor A/0.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.450
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2p1t3TNRetinoic acid receptor RXR-alpha/0.450
2rd2QSIGlutamine--tRNA ligase6.1.1.180.450
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2w3aTOPDihydrofolate reductase1.5.1.30.450
3fhxPXLPyridoxal kinase2.7.1.350.450
3fr5I4AFatty acid-binding protein, adipocyte/0.450
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
3htjETEbrA repressor/0.450
3nxvD2FDihydrofolate reductase1.5.1.30.450
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.450
3vf60H6Glucokinase2.7.1.20.450
3zeiAWHO-acetylserine sulfhydrylase/0.450
4c49HCYCorticosteroid-binding globulin/0.450
4isg1FYGlucokinase2.7.1.20.450
4jkv1KSSmoothened homolog/0.450
4jxxATPGlutamine--tRNA ligase6.1.1.180.450
4ku5DCC3-oxoacyl-[ACP] synthase III/0.450
4x28FDAAcyl-CoA dehydrogenase FadE26/0.450
4x28FDAAcyl-CoA dehydrogenase FadE27/0.450
4zj8SUVOrexin receptor type 1/0.450
3sn6P0GBeta-2 adrenergic receptor/0.450
1cq8PY6Aspartate aminotransferase2.6.1.10.449
1dljUGAUDP-glucose 6-dehydrogenase/0.449
1mepBTNStreptavidin/0.449
1mvsDTMDihydrofolate reductase1.5.1.30.449
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.449
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.449
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.449
1swtBTNStreptavidin/0.449
1u0hFOKAdenylate cyclase type 2/0.449
1u0hFOKAdenylate cyclase type 5/0.449
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2bxoOPBSerum albumin/0.449
2bxqIMNSerum albumin/0.449
2wksCB63-dehydroquinate dehydratase4.2.1.100.449
2xi4AFTAcetylcholinesterase3.1.1.70.449
3dd125DGlycogen phosphorylase, liver form2.4.1.10.449
3elePLPAminotransferase/0.449
3fazNOSPurine nucleoside phosphorylase/0.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.449
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.449
4fal0T0Aldo-keto reductase family 1 member C3/0.449
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.449
4hcy0YNTransketolase/0.449
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.449
4j3mAJ8Tankyrase-22.4.2.300.449
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.449
4n1gCEIObelin/0.449
4rtbSAMPutative thiazole biosynthesis protein ThiH/0.449
4rvgTYDD-mycarose 3-C-methyltransferase/0.449
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.449
5kgpACOPredicted acetyltransferase/0.449
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1rf7DHFDihydrofolate reductase1.5.1.30.448
1towCRZFatty acid-binding protein, adipocyte/0.448
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.448
2e0nSAHPrecorrin-2 C20-methyltransferase/0.448
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.448
2yj5ATPCopper-transporting ATPase/0.448
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3e92G6AMitogen-activated protein kinase 14/0.448
3nxoD2BDihydrofolate reductase1.5.1.30.448
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.448
4jbtASDCytochrome P450 monooxygenase/0.448
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.448
5cxv0HKMuscarinic acetylcholine receptor M1/0.448
1dqaCOA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.447
1e1qADPATP synthase subunit beta, mitochondrial3.6.3.140.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1jlaTNKGag-Pol polyprotein2.7.7.490.447
1pq6965Oxysterols receptor LXR-beta/0.447
1qoqIGPTryptophan synthase alpha chain/0.447
2bf7HBIPteridine reductase 11.5.1.330.447
2c3oTPPPyruvate synthase/0.447
2vcxD26Hematopoietic prostaglandin D synthase/0.447
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.447
3iocA5DPantothenate synthetase6.3.2.10.447
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3p2oNADBifunctional protein FolD/0.447
4bfpSWYTankyrase-22.4.2.300.447
4i1nFOLDihydrofolate reductase1.5.1.30.447
4imfSI3N-acetylneuraminate lyase/0.447
1k9sFM1Purine nucleoside phosphorylase DeoD-type/0.446
1tojHCIAspartate aminotransferase2.6.1.10.446
1ysiN3BBcl-2-like protein 1/0.446
2b99RDLRiboflavin synthase2.5.1.90.446
2cbqTH2Neocarzinostatin/0.446
2f99AKVAklanonic acid methyl ester cyclase AcmA5.5.1.230.446
2fxuBIDActin, alpha skeletal muscle/0.446
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.446
2jj1ADPATP synthase subunit alpha, mitochondrial/0.446
2jj1ADPATP synthase subunit beta, mitochondrial3.6.3.140.446
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
2ydoADNAdenosine receptor A2a/0.446
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.446
3hub469Mitogen-activated protein kinase 14/0.446
3n39FMNProtein NrdI/0.446
4aosNAPSteroid monooxygenase/0.446
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.446
4dya0MFNucleoprotein/0.446
4g8jTHMUridine phosphorylase/0.446
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4iyg1HUStrictosidine synthase4.3.3.20.446
4rbs0RVMetallo-beta-lactamase type 2/0.446
4xp4COCSodium-dependent dopamine transporter/0.446
5k2aZMAAdenosine receptor A2a/0.446
1diuBDMDihydrofolate reductase1.5.1.30.445
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.445
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1swdBTNStreptavidin/0.445
1yslCOAHydroxymethylglutaryl-CoA synthase2.3.3.100.445
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
2r2mI50Prothrombin3.4.21.50.445
2re8GSUGlutamine--tRNA ligase6.1.1.180.445
2tprFADTrypanothione reductase1.8.1.120.445
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.445
2zsdCOAPantothenate kinase2.7.1.330.445
3k47D09Dihydrofolate reductase1.5.1.30.445
3qpg3QPAspartate aminotransferase2.6.1.10.445
3rgaILDEpoxide hydrolase LasB5.5.10.445
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4dhyS41Glucokinase2.7.1.20.445
4dyp0MSNucleoprotein/0.445
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4gt8ADPSensor protein VraS2.7.13.30.445
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.445
1e2nRCAThymidine kinase/0.444
1rsgFADPolyamine oxidase FMS1/0.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.444
1yw9A84Methionine aminopeptidase 2/0.444
1zgbA1EAcetylcholinesterase3.1.1.70.444
2cy2ACOProbable acetyltransferase/0.444
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2wu4HBPAcetylcholinesterase3.1.1.70.444
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.444
3vhmNPKAvidin/0.444
3w6hAZMCarbonic anhydrase 14.2.1.10.444
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4hfp15UProthrombin3.4.21.50.444
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.444
4li61XOTankyrase-12.4.2.300.444
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.444
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.444
5c1gGDUHisto-blood group ABO system transferase/0.444
5ejaTD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.444
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.444
1a9cGTPGTP cyclohydrolase 13.5.4.160.443
1e79ADPATP synthase subunit alpha, mitochondrial/0.443
1e79ADPATP synthase subunit beta, mitochondrial3.6.3.140.443
1odjGMPPurine nucleoside phosphorylase/0.443
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.443
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1qrtATPGlutamine--tRNA ligase6.1.1.180.443
1qtiGNTAcetylcholinesterase3.1.1.70.443
1tllFMNNitric oxide synthase, brain1.14.13.390.443
1u1d181Uridine phosphorylase2.4.2.30.443
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.443
1votHUPAcetylcholinesterase3.1.1.70.443
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.443
2pksG44Prothrombin3.4.21.50.443
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.443
2xupTZ5Acetylcholinesterase3.1.1.70.443
2z4w749Geranylgeranyl pyrophosphate synthase/0.443
3aw9GDUNAD-dependent epimerase/dehydratase/0.443
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.443
3ixp834Ecdysone receptor/0.443
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3v2uATPProtein GAL3/0.443
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.443
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.443
4e31JHZMethyltransferase/0.443
4mk828QGenome polyprotein2.7.7.480.443
4mrxCZHObelin/0.443
4nbiD3YD-tyrosyl-tRNA(Tyr) deacylase/0.443
5ej8TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.443
5fd8A5APutative carboxypeptidase yocD/0.443
1a8t061Metallo-beta-lactamase type 2/0.442
1ej3CZHAequorin-2/0.442
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1wuaAP8Actin, alpha skeletal muscle/0.442
1ykdCMPAdenylate cyclase/0.442
2ea2F77Methionine aminopeptidase 2/0.442
2xuoTZ4Acetylcholinesterase3.1.1.70.442
2yac937Serine/threonine-protein kinase PLK12.7.11.210.442
3dokGWJPol protein/0.442
3dr4G4MGDP-perosamine synthase/0.442
3h59H59Genome polyprotein2.7.7.480.442
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3u9y09LTankyrase-22.4.2.300.442
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.442
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.442
4zowCLMMultidrug transporter MdfA/0.442
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.441
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.441
1h8hADPATP synthase subunit alpha, mitochondrial/0.441
1h8hADPATP synthase subunit beta, mitochondrial3.6.3.140.441
1n8wCOAMalate synthase G/0.441
1rjgSAHLeucine carboxyl methyltransferase 12.1.1.2330.441
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.441
1zgcA2EAcetylcholinesterase3.1.1.70.441
2e8sSAHDiphthine synthase/0.441
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.441
2g78REACellular retinoic acid-binding protein 2/0.441
2il2LIXRenin3.4.23.150.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2xvv9DNSerum albumin/0.441
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.441
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.441
3ipuO40Oxysterols receptor LXR-alpha/0.441
3lzzGDPUncharacterized protein/0.441
3o9lLPNRenin3.4.23.150.441
3ou2SAHSAM-dependent methyltransferase/0.441
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3szfDCQSulfide-quinone reductase/0.441
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.441
4blcNDPCatalase1.11.1.60.441
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.441
4e0u0MVCyclic dipeptide N-prenyltransferase/0.441
4e2yJHZMethyltransferase/0.441
4e32DWNMethyltransferase/0.441
4lt63ATPoly(A) polymerase gamma2.7.7.190.441
4n3l2FNProthrombin3.4.21.50.441
4xg1LLPDiaminopimelate decarboxylase/0.441
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.441
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.441
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.440
1ndjBTNStreptavidin/0.440
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.440
1rkwPNTHTH-type transcriptional regulator QacR/0.440
1typNAPTrypanothione reductase1.8.1.120.440
2dw4FADLysine-specific histone demethylase 1A10.440
2g1y5IGRenin3.4.23.150.440
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.440
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.440
2uuoLK3UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3c1kT15Prothrombin3.4.21.50.440
3e78TPPHigh affinity transport system protein p37/0.440
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3gx9TXDMorphinone reductase/0.440
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.440
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
4ead0NPThymidine phosphorylase2.4.2.40.440
4exsX8ZMetallo-beta-lactamase type 2/0.440
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4i3vNADAldehyde dehydrogenase (NAD+)/0.440
4j7hTRHPCZA361.3/0.440
4jhiEMUNodulin-13/0.440
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440