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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4s32ANPMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4s32ANPMitogen-activated protein kinase 12.7.11.241.000
4s34ANPMitogen-activated protein kinase 12.7.11.240.621
4s33ANPMitogen-activated protein kinase 12.7.11.240.588
4h3qANPMitogen-activated protein kinase 12.7.11.240.506
3c4zADPRhodopsin kinase/0.494
3c4wATPRhodopsin kinase/0.491
4nifANPMitogen-activated protein kinase 12.7.11.240.488
3qyw6PBMitogen-activated protein kinase 12.7.11.240.487
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.481
4jrnANPRhoptry kinase family protein/0.473
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.468
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.467
4fv6E57Mitogen-activated protein kinase 12.7.11.240.466
3qyzZ8BMitogen-activated protein kinase 12.7.11.240.463
2y9qANPMitogen-activated protein kinase 12.7.11.240.461
4fmqANPMitogen-activated protein kinase 12.7.11.240.461
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.460
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.459
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.453
4eooATPCyclin-dependent kinase 22.7.11.220.450
4l9i8PRRhodopsin kinase/0.450
4fuxE75Mitogen-activated protein kinase 12.7.11.240.448
2ojj82AMitogen-activated protein kinase 12.7.11.240.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3sa0NRAMitogen-activated protein kinase 12.7.11.240.443
4fv9E71Mitogen-activated protein kinase 12.7.11.240.442