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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.11.000
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.599
5cnoANPEpidermal growth factor receptor2.7.10.10.546
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.519
5cnnANPEpidermal growth factor receptor2.7.10.10.505
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.458
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.451
5bsgNAPPyrroline-5-carboxylate reductase/0.451
1b38ATPCyclin-dependent kinase 22.7.11.220.441
3w32W32Epidermal growth factor receptor2.7.10.10.441