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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4relKMPGlycosyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4relKMPGlycosyltransferase/1.000
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.550
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.510
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.496
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.486
1xvaSAMGlycine N-methyltransferase2.1.1.200.474
2ed3SAHDiphthine synthase/0.468
4h3g10QBeta-secretase 13.4.23.460.468
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.465
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.465
3af0GDPPantothenate kinase2.7.1.330.463
1ja1FMNNADPH--cytochrome P450 reductase/0.461
4b7754MBeta-secretase 13.4.23.460.461
4frkDWDBeta-secretase 13.4.23.460.461
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.460
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.457
3h3r14HCollagen type IV alpha-3-binding protein/0.457
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.457
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.457
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.456
4iah1DXAlr2278 protein/0.456
2dshSAHDiphthine synthase/0.455
4dju0KKBeta-secretase 13.4.23.460.455
1vceSAHDiphthine synthase/0.453
2zs9ADPPantothenate kinase2.7.1.330.453
4b2gV1NUncharacterized protein/0.453
3l6jZ90Alr2278 protein/0.452
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.450
2gv8NDPThiol-specific monooxygenase1.14.130.449
4azy7F3Beta-secretase 13.4.23.460.449
2p83MR0Beta-secretase 13.4.23.460.448
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.447
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.447
1jdzFMBPurine nucleoside phosphorylase/0.446
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.445
4a87NARMajor pollen allergen Bet v 1-A/0.445
2ejzSAHDiphthine synthase/0.444
2vn1FK5Peptidylprolyl isomerase/0.444
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.444
3oagLPQRenin3.4.23.150.444
4jqh1MFAlr2278 protein/0.444
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.443
2iyaZIOOleandomycin glycosyltransferase/0.443
3k1wBFXRenin3.4.23.150.443
3rsv3RSBeta-secretase 13.4.23.460.443
4acuQN7Beta-secretase 13.4.23.460.443
2rgjFADFlavin-containing monooxygenase/0.442
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4iae1DXAlr2278 protein/0.442
4l7j1W2Beta-secretase 13.4.23.460.442
3owaFADAcyl-CoA dehydrogenase/0.441
4b0qGMFBeta-secretase 13.4.23.460.441
2xlrFADPutative flavin-containing monooxygenase/0.440
3oadLPORenin3.4.23.150.440
4h1e10JBeta-secretase 13.4.23.460.440
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440