sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4raw | ZZ7 | Metallo-beta-lactamase type 2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4raw | ZZ7 | Metallo-beta-lactamase type 2 | / | 1.000 | |
| 4hl1 | ZZ7 | Metallo-beta-lactamase type 2 | / | 0.604 | |
| 4hl2 | ZZ7 | Metallo-beta-lactamase type 2 | / | 0.600 | |
| 4h0d | ZZ7 | Metallo-beta-lactamase type 2 | / | 0.556 | |
| 4ram | PNM | Metallo-beta-lactamase type 2 | / | 0.523 | |
| 4eyb | 0WO | Metallo-beta-lactamase type 2 | / | 0.502 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.500 | |
| 1a8t | 061 | Metallo-beta-lactamase type 2 | / | 0.498 | |
| 1hlk | 113 | Metallo-beta-lactamase type 2 | / | 0.492 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.492 | |
| 4ey2 | 0RM | Metallo-beta-lactamase type 2 | / | 0.487 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.478 | |
| 1jjt | BDS | Beta-lactamase | / | 0.473 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.472 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.472 | |
| 4exs | X8Z | Metallo-beta-lactamase type 2 | / | 0.469 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.466 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.465 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.464 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.464 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.463 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.463 | |
| 4c1f | X8Z | Metallo-beta-lactamase type 2 | / | 0.463 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.461 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.461 | |
| 4eyf | PNK | Metallo-beta-lactamase type 2 | / | 0.460 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.457 | |
| 1jje | BYS | Beta-lactamase | / | 0.457 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.456 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.453 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.453 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 2v00 | V15 | Endothiapepsin | 3.4.23.22 | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.450 | |
| 4iix | 1EG | Microcin C7 self-immunity protein MccF | / | 0.450 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 1kr3 | 113 | Metallo-beta-lactamase type 2 | / | 0.448 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.448 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3t7p | 7SP | Endothiapepsin | 3.4.23.22 | 0.448 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.447 | |
| 3pgi | F41 | Endothiapepsin | 3.4.23.22 | 0.446 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.446 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.445 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.445 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.445 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.443 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 4c35 | NU3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.442 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.441 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.440 |