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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qxq1YEStimulator of interferon genes protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qxq1YEStimulator of interferon genes protein/1.000
4qxr1YEStimulator of interferon genes protein/0.685
4qxp1YEStimulator of interferon genes protein/0.568
4jc51K5Stimulator of interferon genes protein/0.552
4lol1YEStimulator of interferon genes protein/0.543
4loi1YCStimulator of interferon genes protein/0.527
1yb5NAPQuinone oxidoreductase1.6.5.50.520
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.515
1nzfUPGDNA beta-glucosyltransferase/0.505
5d3qGDPDynamin-13.6.5.50.505
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.497
1xe65FPPlasmepsin-23.4.23.390.496
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.496
1g6kNADGlucose 1-dehydrogenase1.1.1.470.495
1x1aSAMC-20 methyltransferase/0.494
1xe55FEPlasmepsin-23.4.23.390.494
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.494
1yqdNAPSinapyl alcohol dehydrogenase/0.493
2b4rAESGlyceraldehyde-3-phosphate dehydrogenase/0.493
2v59LZKBiotin carboxylase6.3.4.140.492
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.492
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.492
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.492
4yaoFMNNADPH--cytochrome P450 reductase/0.492
1nzdUPGDNA beta-glucosyltransferase/0.490
1tehNADAlcohol dehydrogenase class-31.1.1.10.489
2ejvNADL-threonine 3-dehydrogenase/0.489
2po7CHDFerrochelatase, mitochondrial4.99.1.10.489
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.488
2oapANPType II secretion system protein (GspE-2)/0.488
4k28NADShikimate dehydrogenase family protein/0.487
2gjlFMNNitronate monooxygenase1.13.12.160.486
4bfxZVXPantothenate kinase2.7.1.330.486
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.485
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.485
4q71FADBifunctional protein PutA/0.485
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.485
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.484
3b70NAPEnoyl reductase LovC10.484
3tjzGNPADP-ribosylation factor 1/0.484
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.483
4zseANPEpidermal growth factor receptor2.7.10.10.483
3eksCY9Actin-5C/0.482
3qlsNDPDihydrofolate reductase1.5.1.30.482
4nbwNADShort-chain dehydrogenase/reductase SDR/0.482
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.481
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
4dbzNDPPutative ketoacyl reductase1.3.10.481
1gcoNADGlucose 1-dehydrogenase1.1.1.470.480
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.480
2g226IGRenin3.4.23.150.480
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.480
2iyfERYOleandomycin glycosyltransferase2.4.10.480
3cic316Beta-secretase 13.4.23.460.479
3lqfNADGalactitol dehydrogenase/0.479
4bfvZVVPantothenate kinase2.7.1.330.479
4djaFAD(6-4) photolyase/0.479
1ha3MAUElongation factor Tu-A/0.478
2c20NADUDP-glucose 4-epimerase/0.478
2y3rTIRTamL/0.478
3uylTYDProbable NDP-rhamnosyltransferase/0.478
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.477
1u2yGOXPancreatic alpha-amylase/0.477
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
3veu0GOBeta-secretase 13.4.23.460.477
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
2il2LIXRenin3.4.23.150.476
4o1mNADEnoyl-acyl carrier reductase/0.476
1hkuNADC-terminal-binding protein 11.1.10.475
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.475
2uxoTACHTH-type transcriptional regulator TtgR/0.475
3oibFDAPutative acyl-CoA dehydrogenase/0.475
3qt62P0Mevalonate diphosphate decarboxylase/0.475
3sufSUEPolyprotein/0.475
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2freFMNNAD(P)H-flavin oxidoreductase/0.474
2rcyNAPPyrroline-5-carboxylate reductase/0.474
4g3jVNTLanosterol 14-alpha-demethylase/0.474
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.473
1xddAAYIntegrin alpha-L/0.473
2briANPUridylate kinase2.7.4.220.473
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.473
3oafOAGDihydrofolate reductase1.5.1.30.473
3phiNDPShikimate dehydrogenase (NADP(+))/0.473
3w8eNAD3-hydroxybutyrate dehydrogenase/0.473
4du82P0Mevalonate diphosphate decarboxylase/0.473
4egbNADdTDP-glucose 4,6-dehydratase/0.473
4enhFVXCholesterol 24-hydroxylase/0.473
5a3cNADSIR2 family protein/0.473
3bk2U5PRibonuclease J/0.472
3cvuFADRE11660p/0.472
3f03FMNPentaerythritol tetranitrate reductase/0.472
3gqvNAPEnoyl reductase LovC10.472
3ukoNADAlcohol dehydrogenase class-3/0.472
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.472
2an9GDPGuanylate kinase2.7.4.80.471
3p8jFMNPentaerythritol tetranitrate reductase/0.471
4g7gVFVLanosterol 14-alpha-demethylase/0.471
2g1y5IGRenin3.4.23.150.470
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
4exg916Beta-secretase 13.4.23.460.470
4rvnCOAPhenylacetate-coenzyme A ligase/0.470
4v2gITCTetracycline repressor protein class D/0.470
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.470
1w6hTITPlasmepsin-23.4.23.390.469
2a92NAIL-lactate dehydrogenase/0.469
2amt1AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.469
2xpuTDCTetracycline repressor protein class D/0.469
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.469
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.469
4ktl1CQCytochrome P450/0.469
1g1aNADdTDP-glucose 4,6-dehydratase/0.468
2vbdV10Isopenicillin N synthase1.21.3.10.468
2vkeTACTetracycline repressor protein class D/0.468
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3gw9VNILanosterol 14-alpha-demethylase/0.468
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.468
1h73ANPHomoserine kinase2.7.1.390.467
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.467
1z7yAA5Cysteine synthase 12.5.1.470.467
2b53D23Cyclin-dependent kinase 22.7.11.220.467
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.467
3a3gDLZLumazine protein/0.467
3h3t16HCollagen type IV alpha-3-binding protein/0.467
3toxNAPPutative oxidoreductase/0.467
4ambDUDPutative glycosyl transferase/0.467
4dh60KNBeta-secretase 13.4.23.460.467
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.467
4qecNAPElxO/0.467
1e3eNAIAlcohol dehydrogenase 41.1.1.10.466
1f8fNADBenzyl alcohol dehydrogenase/0.466
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.466
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.466
2vkvTDCTetracycline repressor protein class D/0.466
2zbaZBATrichothecene 3-O-acetyltransferase/0.466
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.466
3f3sNADLambda-crystallin homolog/0.466
3h3sH15Collagen type IV alpha-3-binding protein/0.466
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.466
3slkNDPPolyketide synthase extender module 2/0.466
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.466
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.466
1beuIPLTryptophan synthase alpha chain/0.465
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.465
3cid318Beta-secretase 13.4.23.460.465
3f63GTXGlutathione transferase GST1-4/0.465
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.465
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.465
3mx2TTPNucleoprotein/0.465
3p62FMNPentaerythritol tetranitrate reductase/0.465
4gid0GHBeta-secretase 13.4.23.460.465
4l4xNDPAmphI/0.465
4oztP1AEcdysone receptor, putative/0.465
1dr2TAPDihydrofolate reductase1.5.1.30.464
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.464
2dphNADFormaldehyde dismutase/0.464
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.464
2qimZEAClass 10 plant pathogenesis-related protein/0.464
2wxvWXVCyclin-dependent kinase 22.7.11.220.464
2y4gTIRTamL/0.464
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.464
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.464
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.463
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.463
4bfzZVZPantothenate kinase2.7.1.330.463
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.463
4m6jNDPDihydrofolate reductase1.5.1.30.463
4wecNADShort chain dehydrogenase/0.463
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.463
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.462
1dr3TAPDihydrofolate reductase1.5.1.30.462
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.462
1fm4DXCMajor pollen allergen Bet v 1-L/0.462
1zemNADXylitol dehydrogenase/0.462
2ebaFADPutative glutaryl-CoA dehydrogenase/0.462
2gv8NDPThiol-specific monooxygenase1.14.130.462
2iko7IGRenin3.4.23.150.462
2o4cNADErythronate-4-phosphate dehydrogenase/0.462
3c1y2BADNA integrity scanning protein DisA/0.462
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.462
4dptAGSMevalonate diphosphate decarboxylase/0.462
4ipw1G7Mycocyclosin synthase1.14.21.90.462
4oqyNDP(S)-imine reductase/0.462
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.462
5hs1VORLanosterol 14-alpha demethylase/0.462
1udaUFGUDP-glucose 4-epimerase5.1.3.20.461
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.461
2fdpFRPBeta-secretase 13.4.23.460.461
2xx91NFGlutamate receptor 2/0.461
2z1mNDPGDP-mannose 4,6-dehydratase/0.461
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.461
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.461
4a802ANMajor pollen allergen Bet v 1-A/0.461
1geeNADGlucose 1-dehydrogenase1.1.1.470.460
2fy4COACholine O-acetyltransferase2.3.1.60.460
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.460
3b6zCO7Enoyl reductase LovC10.460
3vsxR32Renin3.4.23.150.460
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.460
4ebfNADPhosphonate dehydrogenase1.20.1.10.460
4m83ERYOleandomycin glycosyltransferase2.4.10.460
1ma0NADAlcohol dehydrogenase class-31.1.1.10.459
1mjbACOHistone acetyltransferase ESA1/0.459
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2g1s4IGRenin3.4.23.150.459
2rh9IGPTryptophan synthase alpha chain/0.459
2viyVG3Beta-secretase 13.4.23.460.459
2xlrFADPutative flavin-containing monooxygenase/0.459
2y3rTRKTamL/0.459
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3iaeD7KBenzaldehyde lyase/0.459
3lpjZ75Beta-secretase 13.4.23.460.459
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.459
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.459
4ew2DXYTrifunctional purine biosynthetic protein adenosine-32.1.2.20.459
5a3bAPRSIR2 family protein/0.459
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.459
1bwsNDPGDP-L-fucose synthase/0.458
2abbFMNPentaerythritol tetranitrate reductase/0.458
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.458
3gegNADShort-chain dehydrogenase/reductase SDR/0.458
3hl0NADMaleylacetate reductase/0.458
3s7dLEU_SER_LYS_LYS_MLZN-lysine methyltransferase SMYD2/0.458
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.458
4kbyC2EStimulator of interferon genes protein/0.458
1h50FMNPentaerythritol tetranitrate reductase/0.457
1yqxNAPSinapyl alcohol dehydrogenase/0.457
2af3COAPhosphate acetyltransferase2.3.1.80.457
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
2ylzFADPhenylacetone monooxygenase1.14.13.920.457
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.457
4dc0NDPPutative ketoacyl reductase1.3.10.457
4df2FMNNADPH dehydrogenase/0.457
4gl4NAIAlcohol dehydrogenase class-3/0.457
4u0mGTPCyclic GMP-AMP synthase/0.457
4yaiNAIC alpha-dehydrogenase/0.457
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.456
1qrpHH0Pepsin A-43.4.23.10.456
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2fj1CTCTetracycline repressor protein class D/0.456
2p9dSAHDiphthine synthase/0.456
2qo9ANPEphrin type-A receptor 32.7.10.10.456
2wezZYEBeta-secretase 13.4.23.460.456
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.456
3d7kD7KBenzaldehyde lyase/0.456
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3vdqNAD3-hydroxybutyrate dehydrogenase/0.456
4an4DUDPutative glycosyl transferase/0.456
4lxa1YSBeta-secretase 13.4.23.460.456
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.456
4xfjANPArgininosuccinate synthase/0.456
4xgxADPFAD:protein FMN transferase/0.456
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.456
1drhNAPDihydrofolate reductase1.5.1.30.455
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
1rneC60Renin3.4.23.150.455
2a94AP0L-lactate dehydrogenase1.1.1.270.455
2dxvSAHDiphthine synthase/0.455
2e07SAHDiphthine synthase/0.455
2ed3SAHDiphthine synthase/0.455
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2ok7FADFerredoxin--NADP reductase, apicoplast/0.455
2owgSAHDiphthine synthase/0.455
2wf4ZY4Beta-secretase 13.4.23.460.455
2wi5ZZ5Heat shock protein HSP 90-alpha/0.455
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.455
3s1dZIRCytokinin dehydrogenase 11.5.99.120.455
3tr05GPGuanylate kinase/0.455
3tz3B36Acetyl-CoA carboxylase/0.455
3wv9FEGHmd co-occurring protein HcgE/0.455
4ew3DXZTrifunctional purine biosynthetic protein adenosine-32.1.2.20.455
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.455
4lcjNADC-terminal-binding protein 2/0.455
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.455
5cfpC2EStimulator of interferon genes protein/0.455
1mzs6693-oxoacyl-[acyl-carrier-protein] synthase 3/0.454
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.454
1psa0ZLPepsin A3.4.23.10.454
2cbrA80Cellular retinoic acid-binding protein 1/0.454
2g1r3IGRenin3.4.23.150.454
2lfoGCHFatty acid-binding protein, liver/0.454
2uxpCLMHTH-type transcriptional regulator TtgR/0.454
2y0mACOHistone acetyltransferase KAT8/0.454
3h86AP5Adenylate kinase/0.454
3m6iNADL-arabinitol 4-dehydrogenase1.1.1.120.454
3nbvANPKetohexokinase/0.454
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.454
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.454
4jq9FADDihydrolipoyl dehydrogenase/0.454
4m4922YL-lactate dehydrogenase A chain1.1.1.270.454
4rww2BALmo2692 protein/0.454
5ctsCMCCitrate synthase, mitochondrial2.3.3.10.454
5eoxADPType 4 fimbrial biogenesis protein PilM/0.454
5kwvANPPantothenate synthetase/0.454
2g1n1IGRenin3.4.23.150.453
2huxSAHDiphthine synthase/0.453
2vnaNAPProstaglandin reductase 21.3.1.480.453
3d91REMRenin3.4.23.150.453
3kxw1ZZSaframycin Mx1 synthetase B/0.453
3lsmSFDPyranose 2-oxidase/0.453
3oqfS51Renin3.4.23.150.453
3vucHHERenin3.4.23.150.453
3wqmB29Diterpene synthase3.1.7.80.453
4blrUTPNTPase P4/0.453
4opgFDAConserved Archaeal protein/0.453
4xguADPPutative pachytene checkpoint protein 2/0.453
1bil0IURenin3.4.23.150.452
1fy7COAHistone acetyltransferase ESA1/0.452
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.452
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.452
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.452
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
2ylxFADPhenylacetone monooxygenase1.14.13.920.452
2zb3NDPProstaglandin reductase 21.3.1.480.452
3h6vNS6Glutamate receptor 2/0.452
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
3lzs017Gag-Pol polyprotein3.4.23.160.452
3oixFMNDihydroorotate dehydrogenase/0.452
3qwbNDPProbable quinone oxidoreductase1.6.5.50.452
3tvuB37Acetyl-CoA carboxylase/0.452
3uceNDPDehydrogenase/0.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
4brgGNPEctonucleoside triphosphate diphosphohydrolase I/0.452
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.452
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4q73FADBifunctional protein PutA/0.452
1rfvADPPyridoxal kinase2.7.1.350.451
2dsgSAHDiphthine synthase/0.451
2e4nSAHDiphthine synthase/0.451
2e7rSAHDiphthine synthase/0.451
2ikuLIYRenin3.4.23.150.451
2ohvNHLGlutamate racemase/0.451
2wf1ZY1Beta-secretase 13.4.23.460.451
2xb9XNW3-dehydroquinate dehydratase4.2.1.100.451
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3dmeFADPutative conserved exported protein/0.451
3gfbNADL-threonine 3-dehydrogenase/0.451
3in6FMNUncharacterized protein/0.451
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.451
3r7kFDAProbable acyl CoA dehydrogenase/0.451
3to3ATPPetrobactin biosynthesis protein AsbB/0.451
3vydVYDRenin3.4.23.150.451
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.451
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.451
4q0kGA3Phytohormone-binding protein/0.451
4q72FADBifunctional protein PutA/0.451
4y9qC2EUncharacterized protein/0.451
4yntFDAGlucose oxidase, putative/0.451
1f0xFADD-lactate dehydrogenase1.1.1.280.450
1pjcNADAlanine dehydrogenase/0.450
1qorNDPQuinone oxidoreductase 1/0.450
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.450
1w4zNAPPutative ketoacyl reductase1.3.10.450
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.450
2e8sSAHDiphthine synthase/0.450
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.450
2hu2NADC-terminal binding protein 1/0.450
2huvSAHDiphthine synthase/0.450
2jn3JN3Fatty acid-binding protein, liver/0.450
2ou2ACOHistone acetyltransferase KAT5/0.450
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.450
3ieuGDPGTPase Era/0.450
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.450
3nxxNDPDihydrofolate reductase1.5.1.30.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.450
4jjiNADAlcohol dehydrogenase class-3/0.450
4wriOKAOkadaic acid binding protein 2-alpha/0.450
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.450
6ctsCICCitrate synthase, mitochondrial2.3.3.10.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1ds7FMNOxygen-insensitive NAD(P)H nitroreductase/0.449
1mj9COAHistone acetyltransferase ESA1/0.449
1mjaCOAHistone acetyltransferase ESA1/0.449
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.449
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.449
1rfuADPPyridoxal kinase2.7.1.350.449
2bjfDXCCholoylglycine hydrolase3.5.1.240.449
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.449
2rlcCHDCholoylglycine hydrolase3.5.1.240.449
2w6qOA5Biotin carboxylase6.3.4.140.449
2wpa889Cyclin-dependent kinase 22.7.11.220.449
2znnS44Peroxisome proliferator-activated receptor alpha/0.449
3d3wNAPL-xylulose reductase1.1.1.100.449
3d84NDPDihydrofolate reductase1.5.1.30.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3h2sNDPPutative NADH-flavin reductase/0.449
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.449
4c4oNADSADH/0.449
4dplNAPMalonyl-CoA reductase1.2.1.750.449
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.449
4iawLIZNeutrophil gelatinase-associated lipocalin/0.449
4lrlTTPHD domain protein/0.449
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
4zgsNADPutative D-lactate dehydrogenase/0.449
5cnoANPEpidermal growth factor receptor2.7.10.10.449
1cscCMCCitrate synthase, mitochondrial2.3.3.10.448
1hb3SCVIsopenicillin N synthase1.21.3.10.448
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
1uxyEPUUDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.448
1yqzCOACoenzyme A disulfide reductase/0.448
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
2el0SAHDiphthine synthase/0.448
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.448
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.448
2i7pACOPantothenate kinase 32.7.1.330.448
2vprTDCTetracycline repressor protein class H/0.448
2y3sTIRTamL/0.448
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.448
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.448
3cosNADAlcohol dehydrogenase 41.1.1.10.448
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3gwfNAPCyclohexanone monooxygenase/0.448
3ig6438Urokinase-type plasminogen activator3.4.21.730.448
3lsiFADPyranose 2-oxidase/0.448
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.448
3wquATPCell division protein FtsA/0.448
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.448
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.448
4a862ANMajor pollen allergen Bet v 1-A/0.448
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4b7xNAPProbable oxidoreductase/0.448
4fryNADPutative signal-transduction protein with CBS domains/0.448
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.448
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.448
4jx1CAHCamphor 5-monooxygenase1.14.15.10.448
4l0qNADAlcohol dehydrogenase class-3/0.448
4lx9ACON-alpha-acetyltransferase2.3.10.448
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.448
4yxm2BADNA integrity scanning protein DisA/0.448
5dbgNADIridoid synthase1.3.1.990.448
1vikBAYGag-Pol polyprotein/0.447
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.447
2cv2GSUGlutamate--tRNA ligase6.1.1.170.447
2eklNADD-3-phosphoglycerate dehydrogenase/0.447
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.447
2fzwNADAlcohol dehydrogenase class-31.1.1.10.447
2gjnFMNNitronate monooxygenase1.13.12.160.447
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.447
2q7vFADThioredoxin reductase/0.447
2qbmCAMCamphor 5-monooxygenase1.14.15.10.447
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.447
2v16C47Renin3.4.23.150.447
3bbrBHYGlutamate receptor 2/0.447
3ctyFADProbable thioredoxin reductase/0.447
3ixp834Ecdysone receptor/0.447
3qizQI2Botulinum neurotoxin type A3.4.24.690.447
4esoNAPPutative oxidoreductase/0.447
4lxk1YTBeta-secretase 13.4.23.460.447
4xr9NADCalS8/0.447
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.447
5f8eSAHPossible transcriptional regulatory protein/0.447
5jlaNADPutative short-chain dehydrogenase/reductase/0.447
1culFOKAdenylate cyclase type 2/0.446
1culFOKAdenylate cyclase type 5/0.446
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.446
1esvLARActin, alpha skeletal muscle/0.446
1ia1NDPDihydrofolate reductase1.5.1.30.446
1jkx138Phosphoribosylglycinamide formyltransferase/0.446
1v35NAIEnoyl-ACP reductase/0.446
1vceSAHDiphthine synthase/0.446
1vrwNAIEnoyl-ACP reductase/0.446
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.446
2dvlFADAcyl-CoA dehydrogenase/0.446
2ejzSAHDiphthine synthase/0.446
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.446
2j5xGSPADP-ribosylation factor 6/0.446
3ai2NDPNADPH-sorbose reductase/0.446
3coy53HPantothenate synthetase6.3.2.10.446
3k5dXLIBeta-secretase 13.4.23.460.446
3p74FMNPentaerythritol tetranitrate reductase/0.446
3pw8ACO1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.446
3rpeFADPutative modulator of drug activity/0.446
4emtC2EStimulator of interferon genes protein/0.446
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.446
5a9sNAPPutative dehydrogenase/0.446
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.445
1e3lNADAlcohol dehydrogenase 41.1.1.10.445
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.445
1hbvGANGag-Pol polyprotein/0.445
1j21ATPArgininosuccinate synthase/0.445
1szgFNSCytochrome b2, mitochondrial1.1.2.30.445
2ft9CHDFatty acid-binding protein 2, liver/0.445
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.445
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.445
2qenADPWalker-Type ATPase/0.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.445
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.445
3hj9FMNUncharacterized protein/0.445
3lpkZ76Beta-secretase 13.4.23.460.445
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.445
3v2uATPProtein GAL3/0.445
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.445
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4irnFADAnaB/0.445
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.445
4prvADPDNA gyrase subunit B/0.445
4xq9NADHomospermidine synthase2.5.1.440.445
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.445
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.444
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.444
1k7l544Peroxisome proliferator-activated receptor alpha/0.444
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.444
2dftADPShikimate kinase2.7.1.710.444
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.444
2iegFRYGlycogen phosphorylase, muscle form2.4.1.10.444
2nniMTKCytochrome P450 2C8/0.444
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.444
2v58LZJBiotin carboxylase6.3.4.140.444
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.444
2xhd7T9Glutamate receptor 2/0.444
3atyFMNProstaglandin F2a synthase/0.444
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3gvhNADMalate dehydrogenase/0.444
3ohh3HHBeta-secretase 13.4.23.460.444
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.444
3x22FMNOxygen-insensitive NAD(P)H nitroreductase/0.444
3zc3NAPFerredoxin--NADP reductase1.18.1.20.444
4e5yNDPGDP-L-fucose synthase1.1.1.2710.444
4hwkNAPSepiapterin reductase1.1.1.1530.444
4k6fNAPPutative Acetoacetyl-CoA reductase/0.444
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.444
4qedNAPElxO/0.444
4tvbNADHomospermidine synthase2.5.1.440.444
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.444
5jscFADPutative acyl-CoA dehydrogenase/0.444
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.443
1ddsMTXDihydrofolate reductase1.5.1.30.443
1ja0FMNNADPH--cytochrome P450 reductase/0.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.443
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2f3rG5PGuanylate kinase2.7.4.80.443
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
2fznFADBifunctional protein PutA1.5.5.20.443
2gvdFKPAdenylate cyclase type 2/0.443
2gvdFKPAdenylate cyclase type 5/0.443
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
2iviACWIsopenicillin N synthase1.21.3.10.443
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2p5uNADUDP-glucose 4-epimerase/0.443
2v5aLZLBiotin carboxylase6.3.4.140.443
2vwqNAPGlucose 1-dehydrogenase/0.443
3apwDP0Alpha-1-acid glycoprotein 2/0.443
3b2sB2STrichothecene 3-O-acetyltransferase/0.443
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
3lbeCOAUncharacterized protein/0.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3ojwFMNNADPH--cytochrome P450 reductase/0.443
3r83Z14Cyclin-dependent kinase 22.7.11.220.443
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.443
3wrhCAMCamphor 5-monooxygenase1.14.15.10.443
4b3aTACTetracycline repressor protein class D/0.443
4dfg0JVGag-Pol polyprotein3.4.23.160.443
4dieC5PCytidylate kinase/0.443
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.443
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.443
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
4xmxBESAminopeptidase N3.4.11.20.443
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.443
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
5dp2NAPCurF/0.443
1a5bIGPTryptophan synthase alpha chain/0.442
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.442
1d7aAIRN5-carboxyaminoimidazole ribonucleotide mutase/0.442
1h51FMNPentaerythritol tetranitrate reductase/0.442
1jedADPSulfate adenylyltransferase/0.442
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ed5SAHDiphthine synthase/0.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.442
2givACOHistone acetyltransferase KAT8/0.442
2jb4A14Isopenicillin N synthase1.21.3.10.442
2nq8ZIDEnoyl-ACP reductase/0.442
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.442
2q9fC3SCholesterol 24-hydroxylase/0.442
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3fwjCAMCamphor 5-monooxygenase1.14.15.10.442
3h3r14HCollagen type IV alpha-3-binding protein/0.442
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.442
3l0lHC3Nuclear receptor ROR-gamma/0.442
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.442
3nsh957Beta-secretase 13.4.23.460.442
3q43D66M1 family aminopeptidase3.4.110.442
3r9uFADThioredoxin reductase/0.442
4a81DXCMajor pollen allergen Bet v 1-A/0.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.442
4i0i957Beta-secretase 13.4.23.460.442
4i1iNADMalate dehydrogenase/0.442
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
4lopSB4Mitogen-activated protein kinase 14/0.442
4lxm1YUBeta-secretase 13.4.23.460.442
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.442
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.442
4xgiNADGlutamate dehydrogenase/0.442
4yaf2AMNADPH--cytochrome P450 reductase/0.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5ftcADPTPR domain protein/0.442
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.441
1d0mBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.441
1kp3ATPArgininosuccinate synthase6.3.4.50.441
1me6IVSPlasmepsin-23.4.23.390.441
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.441
1p4aPCPPur operon repressor/0.441
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.441
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2dteNAIGlucose 1-dehydrogenase related protein/0.441
2ed4FAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.441
2emrSAHDiphthine synthase/0.441
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.441
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.441
2y65ADPKinesin heavy chain/0.441
2z54AB1Gag-Pol polyprotein3.4.23.160.441
3a0tADPSensor histidine kinase/0.441
3ad9NADSubunit alpha of sarocosine oxidase/0.441
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.441
3ibqATPPyridoxal kinase/0.441
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.441
3k5fAYHBeta-secretase 13.4.23.460.441
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.441
3mjeNDPAmphB/0.441
3qrwNDPPutative ketoacyl reductase1.3.10.441
3rv9RVDSalicylate synthase/0.441
3sm8FNKFAD-dependent catabolic D-arginine dehydrogenase DauA/0.441
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
4btjADPTau-tubulin kinase 12.7.11.10.441
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.441
4gdcNDPUDP-galactopyranose mutase/0.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
4pzsACOHistone acetyltransferase p300/0.441
4yagNAIC alpha-dehydrogenase/0.441
5c1d12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.441
5hg0SAMPantothenate synthetase/0.441
1ae1NAPTropinone reductase 1/0.440
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.440
1f20FADNitric oxide synthase, brain1.14.13.390.440
1i5bANPChemotaxis protein CheA2.7.13.30.440
1j1zATPArgininosuccinate synthase/0.440
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.440
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.440
1nhqFADNADH peroxidase1.11.1.10.440
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1v9aSAHUncharacterized protein/0.440
1w4aAPCNTPase P4/0.440
2dshSAHDiphthine synthase/0.440
2dsiSAHDiphthine synthase/0.440
2eixFADNADH-cytochrome b5 reductase/0.440
2huqSAHDiphthine synthase/0.440
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2iqgF2IBeta-secretase 13.4.23.460.440
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.440
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.440
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.440
2wsbNADGalactitol dehydrogenase/0.440
2xvhFADPutative flavin-containing monooxygenase/0.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.440
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.440
3nutSAHPrecorrin-3 methylase/0.440
4b1rITCTetracycline repressor protein class D/0.440
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.440
4hxyNDPPlm1/0.440
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
4yaw2AMNADPH--cytochrome P450 reductase/0.440
4yj2GTPTubulin alpha-1B chain/0.440
5eoyADPType 4 fimbrial biogenesis protein PilM/0.440
5ftfADPTPR domain protein/0.440