sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4qxm | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4qxm | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 1.000 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.589 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.589 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.575 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.571 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.565 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.554 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.551 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.545 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.533 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.529 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.528 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.518 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.514 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.512 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.510 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.509 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.508 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.505 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.498 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.497 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.497 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.495 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.495 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.495 | |
| 2ohv | NHL | Glutamate racemase | / | 0.494 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.490 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.490 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.487 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.487 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.487 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.484 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.484 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.482 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.481 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.481 | |
| 3zux | TCH | Transporter | / | 0.481 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.480 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.480 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.480 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.478 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.478 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.477 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 4jf1 | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.476 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.476 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.475 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.475 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.475 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.475 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.473 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.471 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.471 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.470 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.469 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.469 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.469 | |
| 5a3c | NAD | SIR2 family protein | / | 0.469 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.468 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.468 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.468 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.467 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.467 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.467 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.467 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.466 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.466 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.466 | |
| 5ftf | ADP | TPR domain protein | / | 0.466 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.466 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.465 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.464 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.464 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.464 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.463 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.462 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.462 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.461 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.461 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.460 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.460 | |
| 2ejz | SAH | Diphthine synthase | / | 0.460 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.460 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.459 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.458 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.458 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.458 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.458 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.457 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.457 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 3zuy | TCH | Transporter | / | 0.457 | |
| 4h6p | FMN | Chromate reductase | / | 0.457 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.456 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1tys | DHF | Thymidylate synthase | / | 0.455 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.455 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.455 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.454 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 4dja | FAD | (6-4) photolyase | / | 0.454 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.454 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.454 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.453 | |
| 3b99 | U51 | Prostacyclin synthase | / | 0.453 | |
| 4b70 | WM9 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.452 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.452 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.452 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.452 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.452 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.452 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.452 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.452 | |
| 4l8u | 9AZ | Serum albumin | / | 0.452 | |
| 4o67 | 1SY | Cyclic GMP-AMP synthase | / | 0.452 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.451 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.451 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.451 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3gob | HXX | DdmC | / | 0.451 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.451 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.450 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.450 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.450 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.450 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.450 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.449 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2y3s | TIR | TamL | / | 0.449 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.449 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.449 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.448 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.448 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4eki | 0QK | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.448 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.447 | |
| 2uxi | G50 | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4qnw | FMN | Chanoclavine-I aldehyde reductase easA | / | 0.447 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.447 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1r2j | FAD | FkbI | / | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.446 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.446 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.446 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.445 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.445 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.445 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.445 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 1jn0 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.444 | |
| 1m9m | 6NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.444 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.444 | |
| 2wq7 | FAD | RE11660p | / | 0.444 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4kwh | NAP | Reductase homolog | / | 0.444 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.444 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.444 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 1tsy | UMP | Thymidylate synthase | / | 0.443 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.442 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.442 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.442 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.442 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.442 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.442 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.442 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.442 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.441 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2wb2 | FAD | RE11660p | / | 0.441 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.441 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3afh | GSU | Glutamate--tRNA ligase 2 | / | 0.441 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.441 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.441 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.440 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.440 | |
| 4g2r | H1L | Probable propionyl-CoA carboxylase beta chain 6 | 6.4.1.3 | 0.440 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4y1b | NAP | AntE | / | 0.440 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.440 |