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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qo9627Serine/threonine-protein kinase 242.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4qo9627Serine/threonine-protein kinase 242.7.11.11.000
3a7hATPSerine/threonine-protein kinase 242.7.11.10.555
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.543
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.533
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.533
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.528
4qmlANPSerine/threonine-protein kinase 242.7.11.10.523
2wxvWXVCyclin-dependent kinase 22.7.11.220.522
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.522
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.522
3c4xATPRhodopsin kinase/0.521
4wboANWRhodopsin kinase/0.519
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.519
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.514
2j0m4STFocal adhesion kinase 12.7.10.20.513
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.512
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.506
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.505
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.504
4fv6E57Mitogen-activated protein kinase 12.7.11.240.504
3begANPSRSF protein kinase 12.7.11.10.501
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.501
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.500
4qmzB49Serine/threonine-protein kinase 242.7.11.10.500
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.499
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.499
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.499
3t8oATPRhodopsin kinase/0.498
4gmy0X5Tyrosine-protein kinase JAK2/0.498
2qo9ANPEphrin type-A receptor 32.7.10.10.497
4l9i8PRRhodopsin kinase/0.497
2hog710Serine/threonine-protein kinase Chk12.7.11.10.496
2ittAEEEpidermal growth factor receptor2.7.10.10.496
4fob0USALK tyrosine kinase receptor2.7.10.10.496
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.495
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.493
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.493
4gk4L90Ephrin type-A receptor 32.7.10.10.493
2j0lANPFocal adhesion kinase 12.7.10.20.492
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.492
4jia1K3Tyrosine-protein kinase JAK2/0.492
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.491
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.490
4aguD15Cyclin-dependent kinase-like 1/0.490
4fyn0VETyrosine-protein kinase SYK2.7.10.20.490
2yaaATPDeath-associated protein kinase 2/0.489
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.489
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.488
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.487
2qoqANPEphrin type-A receptor 32.7.10.10.487
3pxkPXKFocal adhesion kinase 12.7.10.20.486
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.486
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
4ansVGHALK tyrosine kinase receptor2.7.10.10.485
4qnaX11Serine/threonine-protein kinase 242.7.11.10.485
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.484
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.484
3e5aVX6Aurora kinase A2.7.11.10.483
4bchT7ZCyclin-dependent kinase 92.7.11.220.483
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.482
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.482
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.482
2yfxVGHALK tyrosine kinase receptor2.7.10.10.481
3vjoANPEpidermal growth factor receptor2.7.10.10.481
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.481
4j95ACPFibroblast growth factor receptor 2/0.481
1mqbANPEphrin type-A receptor 22.7.10.10.480
1pjkANPCasein kinase II subunit alpha2.7.11.10.480
2c4g514Cyclin-dependent kinase 22.7.11.220.480
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.480
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.479
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.479
1bygSTUTyrosine-protein kinase CSK/0.478
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.478
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.478
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.478
4grb0XGCasein kinase II subunit alpha2.7.11.10.478
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.476
2acxANPG protein-coupled receptor kinase 62.7.11.160.476
2c6eHPMAurora kinase A2.7.11.10.476
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.476
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.476
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.476
3i60E86Mitogen-activated protein kinase 12.7.11.240.475
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.475
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4anqVGHALK tyrosine kinase receptor2.7.10.10.474
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.474
4g2fC07Ephrin type-A receptor 32.7.10.10.474
2xvdAS6Ephrin type-B receptor 42.7.10.10.473
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.473
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.473
3c4wATPRhodopsin kinase/0.472
4fz60VGTyrosine-protein kinase SYK2.7.10.20.472
4qms1N1Serine/threonine-protein kinase 242.7.11.10.472
5aacVGHALK tyrosine kinase receptor2.7.10.10.472
2wihP48Cyclin-dependent kinase 22.7.11.220.471
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.471
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.471
3w2o03PEpidermal growth factor receptor2.7.10.10.471
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.470
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.470
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.470
4qmySTUSerine/threonine-protein kinase 242.7.11.10.470
4xhgADPUncharacterized protein/0.470
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.469
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.469
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.469
4id71G0Activated CDC42 kinase 1/0.469
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.468
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.468
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.467
2etm7PYFocal adhesion kinase 12.7.10.20.467
2ijmATPFocal adhesion kinase 12.7.10.20.467
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.467
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
1finATPCyclin-dependent kinase 22.7.11.220.466
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.466
4fod0UVALK tyrosine kinase receptor2.7.10.10.466
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.466
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.466
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.465
2j0j4STFocal adhesion kinase 12.7.10.20.465
2xp2VGHALK tyrosine kinase receptor2.7.10.10.465
3bqr4RBDeath-associated protein kinase 3/0.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
4btjATPTau-tubulin kinase 12.7.11.10.465
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.465
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.465
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.464
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.464
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.464
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.464
5ap7SVEDual specificity protein kinase TTK2.7.12.10.464
2xb7GUIALK tyrosine kinase receptor2.7.10.10.463
2xyuQ9GEphrin type-A receptor 42.7.10.10.463
3my5RFZCyclin-dependent kinase 22.7.11.220.463
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
4j99ACPFibroblast growth factor receptor 2/0.463
4ji91M3Tyrosine-protein kinase JAK2/0.463
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.462
2itwITQEpidermal growth factor receptor2.7.10.10.462
2qo7ANPEphrin type-A receptor 32.7.10.10.462
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.461
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.461
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.461
2itvANPEpidermal growth factor receptor2.7.10.10.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.461
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.461
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.460
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.460
2izuP01Casein kinase I isoform gamma-32.7.11.10.460
2x1nX1NCyclin-dependent kinase 22.7.11.220.460
3lltANPProtein serine/threonine kinase-1/0.460
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.460
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.459
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2vd5BI8Myotonin-protein kinase2.7.11.10.459
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.459
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.459
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.459
3vtdTKDVitamin D3 receptor/0.459
1zrzBI1Protein kinase C iota type2.7.11.130.458
2ghmLICMitogen-activated protein kinase 14/0.458
2of4979Tyrosine-protein kinase Lck2.7.10.20.458
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.458
3d7tSTUTyrosine-protein kinase CSK/0.458
3igoANPCalmodulin-domain protein kinase 1, putative/0.458
4gk3L87Ephrin type-A receptor 32.7.10.10.458
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.458
2xikJ60Serine/threonine-protein kinase 252.7.11.10.457
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.457
3qc9ADPRhodopsin kinase/0.457
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.457
5aabVGHALK tyrosine kinase receptor2.7.10.10.457
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.456
4btjADPTau-tubulin kinase 12.7.11.10.456
4foc0UUALK tyrosine kinase receptor2.7.10.10.456
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2bfyH1NAurora kinase B-A2.7.11.10.455
2izt23DCasein kinase I isoform gamma-32.7.11.10.455
2qocANPEphrin type-A receptor 32.7.10.10.455
1m17AQ4Epidermal growth factor receptor2.7.10.10.454
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.454
2bujSTUSerine/threonine-protein kinase 16/0.454
2henADPEphrin type-B receptor 22.7.10.10.454
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.454
2x9fX9FEphrin type-B receptor 42.7.10.10.454
3lpbNVBTyrosine-protein kinase JAK2/0.454
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.454
3zxtACPDeath-associated protein kinase 12.7.11.10.454
2ijmADPFocal adhesion kinase 12.7.10.20.453
2itnANPEpidermal growth factor receptor2.7.10.10.453
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.453
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.453
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.453
4b8mVX6Aurora kinase B-A2.7.11.10.453
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.452
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3u4uLNHCasein kinase II subunit alpha2.7.11.10.452
3zh8C58Protein kinase C iota type2.7.11.130.452
4c3pACPAurora kinase A2.7.11.10.452
1i44ACPInsulin receptor2.7.10.10.451
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.451
3du8553Glycogen synthase kinase-3 beta2.7.11.260.451
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.451
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.450
3js2VM1Fibroblast growth factor receptor 1/0.450
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.450
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.450
4j97ACPFibroblast growth factor receptor 2/0.450
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.449
4fv9E71Mitogen-activated protein kinase 12.7.11.240.449
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.449
5aaaVGHALK tyrosine kinase receptor2.7.10.10.449
2ituITQEpidermal growth factor receptor2.7.10.10.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
4aqc88ATyrosine-protein kinase JAK2/0.448
4jqeANPCasein kinase II subunit alpha2.7.11.10.448
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.447
3zewSTUEphrin type-B receptor 42.7.10.10.447
4b99R4LMitogen-activated protein kinase 72.7.11.240.447
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.447
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.447
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.447
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.446
2x6dX6DAurora kinase A2.7.11.10.446
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.446
4enhFVXCholesterol 24-hydroxylase/0.446
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.445
2pwlACPFibroblast growth factor receptor 2/0.445
2vzmNRBCytochrome P450 monooxygenase PikC/0.445
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.445
2wpa889Cyclin-dependent kinase 22.7.11.220.445
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.445
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.445
3ggfGVDSerine/threonine-protein kinase 26/0.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.445
3zep1NXTyrosine-protein kinase JAK32.7.10.20.445
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.445
4hgs15GCasein kinase I isoform gamma-32.7.11.10.445
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3bu5ATPInsulin receptor2.7.10.10.444
3lctADPALK tyrosine kinase receptor2.7.10.10.444
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4jrvKJVEpidermal growth factor receptor2.7.10.10.444
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.443
2ojj82AMitogen-activated protein kinase 12.7.11.240.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.443
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.443
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.443
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.443
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.443
4fuxE75Mitogen-activated protein kinase 12.7.11.240.443
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.443
5l8lADPAurora kinase A2.7.11.10.443
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.442
4eym0RXMitogen-activated protein kinase 132.7.11.240.442
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.442
4hge15VTyrosine-protein kinase JAK2/0.442
5av2KMPDeath-associated protein kinase 12.7.11.10.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.441
2izsBRQCasein kinase I isoform gamma-32.7.11.10.441
3ac1KZITyrosine-protein kinase Lck2.7.10.20.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.441
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.441
4jr3KJREpidermal growth factor receptor2.7.10.10.441
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.441
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.440
2fgiPD1Fibroblast growth factor receptor 1/0.440
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3emg685Tyrosine-protein kinase SYK2.7.10.20.440
3mdvCL6Cholesterol 24-hydroxylase/0.440
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.440
4cd0AWJALK tyrosine kinase receptor2.7.10.10.440
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.440
4joa3DKALK tyrosine kinase receptor2.7.10.10.440
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440