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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qmpDKISerine/threonine-protein kinase 242.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qmpDKISerine/threonine-protein kinase 242.7.11.11.000
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.535
2xikJ60Serine/threonine-protein kinase 252.7.11.10.517
3ggfGVDSerine/threonine-protein kinase 26/0.512
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.502
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.501
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.498
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.498
5e8wSTUTGF-beta receptor type-12.7.11.300.497
2iw84SPCyclin-dependent kinase 22.7.11.220.493
3rmf20ZCyclin-dependent kinase 22.7.11.220.493
3s1h56ZCyclin-dependent kinase 22.7.11.220.488
3rak03ZCyclin-dependent kinase 22.7.11.220.485
3r9dX6BCyclin-dependent kinase 22.7.11.220.482
1oi9N20Cyclin-dependent kinase 22.7.11.220.477
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4fko20KCyclin-dependent kinase 22.7.11.220.477
3qxpX64Cyclin-dependent kinase 22.7.11.220.476
4fkw62KCyclin-dependent kinase 22.7.11.220.475
1di8DTQCyclin-dependent kinase 22.7.11.220.472
2wihP48Cyclin-dependent kinase 22.7.11.220.472
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.472
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.472
1g5sI17Cyclin-dependent kinase 22.7.11.220.471
1oiyN41Cyclin-dependent kinase 22.7.11.220.471
3ral04ZCyclin-dependent kinase 22.7.11.220.471
3rpv26ZCyclin-dependent kinase 22.7.11.220.471
3uli1N3Cyclin-dependent kinase 22.7.11.220.471
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.468
2wotZZGTGF-beta receptor type-12.7.11.300.466
4fkr45KCyclin-dependent kinase 22.7.11.220.466
2xmyCDKCyclin-dependent kinase 22.7.11.220.465
4qms1N1Serine/threonine-protein kinase 242.7.11.10.465
1fvv107Cyclin-dependent kinase 22.7.11.220.464
3qu0X40Cyclin-dependent kinase 22.7.11.220.464
1gij2PUCyclin-dependent kinase 22.7.11.220.463
4fx360KCyclin-dependent kinase 22.7.11.220.463
2eufLQQCyclin-dependent kinase 62.7.11.220.462
3qtxX43Cyclin-dependent kinase 22.7.11.220.462
4acm7YGCyclin-dependent kinase 22.7.11.220.461
4bgh3I6Cyclin-dependent kinase 22.7.11.220.460
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.460
4gmy0X5Tyrosine-protein kinase JAK2/0.460
1gih1PUCyclin-dependent kinase 22.7.11.220.459
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.459
3zep1NXTyrosine-protein kinase JAK32.7.10.20.459
1urwI1PCyclin-dependent kinase 22.7.11.220.458
3sw719KCyclin-dependent kinase 22.7.11.220.458
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.458
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.457
1xjdSTUProtein kinase C theta type2.7.11.130.456
3qtzX42Cyclin-dependent kinase 22.7.11.220.456
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.456
1ke6LS2Cyclin-dependent kinase 22.7.11.220.455
1w6hTITPlasmepsin-23.4.23.390.454
3rk507ZCyclin-dependent kinase 22.7.11.220.454
4bgg844Activin receptor type-12.7.11.300.454
4qmzB49Serine/threonine-protein kinase 242.7.11.10.452
1h1s4SPCyclin-dependent kinase 22.7.11.220.451
1pxmCK5Cyclin-dependent kinase 22.7.11.220.451
1y91CT9Cyclin-dependent kinase 22.7.11.220.451
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.451
3qzhX69Cyclin-dependent kinase 22.7.11.220.451
3rk708ZCyclin-dependent kinase 22.7.11.220.451
2w06FRVCyclin-dependent kinase 22.7.11.220.450
3zh8C58Protein kinase C iota type2.7.11.130.449
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.448
4erwSTUCyclin-dependent kinase 22.7.11.220.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
2iw94SPCyclin-dependent kinase 22.7.11.220.447
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.447
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.447
1w0xOLOCyclin-dependent kinase 22.7.11.220.446
3rni21ZCyclin-dependent kinase 22.7.11.220.446
3sw418KCyclin-dependent kinase 22.7.11.220.446
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.446
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.446
2w05FRTCyclin-dependent kinase 22.7.11.220.444
2wxvWXVCyclin-dependent kinase 22.7.11.220.444
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
3rk909ZCyclin-dependent kinase 22.7.11.220.443
3sqq99ZCyclin-dependent kinase 22.7.11.220.443
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.443
1h1r6CPCyclin-dependent kinase 22.7.11.220.442
2bhhRYUCyclin-dependent kinase 22.7.11.220.442
2w1hL0FCyclin-dependent kinase 22.7.11.220.442
3ti1B49Cyclin-dependent kinase 22.7.11.220.442
4qmySTUSerine/threonine-protein kinase 242.7.11.10.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
1p2a5BNCyclin-dependent kinase 22.7.11.220.441
2c5nCK8Cyclin-dependent kinase 22.7.11.220.441
2xnbY8LCyclin-dependent kinase 22.7.11.220.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.441
1ke7LS3Cyclin-dependent kinase 22.7.11.220.440
1lf2R37Plasmepsin-23.4.23.390.440
2b7aIZATyrosine-protein kinase JAK2/0.440
2i40BLZCyclin-dependent kinase 22.7.11.220.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.440
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.440