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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qmlANPSerine/threonine-protein kinase 242.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qmlANPSerine/threonine-protein kinase 242.7.11.11.000
3c4xATPRhodopsin kinase/0.493
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.490
3c4zADPRhodopsin kinase/0.488
2j0lANPFocal adhesion kinase 12.7.10.20.485
3t8oATPRhodopsin kinase/0.485
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.475
4c3pACPAurora kinase A2.7.11.10.473
4j95ACPFibroblast growth factor receptor 2/0.470
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.470
1i44ACPInsulin receptor2.7.10.10.468
4xlvACPInsulin receptor2.7.10.10.466
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.465
3a7hATPSerine/threonine-protein kinase 242.7.11.10.462
4j99ACPFibroblast growth factor receptor 2/0.462
3c4wATPRhodopsin kinase/0.460
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.456
4jia1K3Tyrosine-protein kinase JAK2/0.454
4qnyANPMitogen activated protein kinase, putative/0.454
3qc9ADPRhodopsin kinase/0.449
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.449
2ijmATPFocal adhesion kinase 12.7.10.20.448
2c6eHPMAurora kinase A2.7.11.10.446
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.445
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.442
5ap7SVEDual specificity protein kinase TTK2.7.12.10.442
2qoqANPEphrin type-A receptor 32.7.10.10.440
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440