sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ql3 | GDP | GTPase KRas |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ql3 | GDP | GTPase KRas | / | 1.000 | |
| 4epx | GDP | GTPase KRas | / | 0.871 | |
| 4q03 | GDP | GTPase KRas | / | 0.834 | |
| 4ldj | GDP | GTPase KRas | / | 0.743 | |
| 4tq9 | GDP | GTPase KRas | / | 0.637 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.608 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.604 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.600 | |
| 4l9s | GDP | GTPase HRas | / | 0.592 | |
| 4luc | GDP | GTPase KRas | / | 0.589 | |
| 4q02 | GDP | GTPase KRas | / | 0.589 | |
| 4l8g | GDP | GTPase KRas | / | 0.580 | |
| 4lpk | GDP | GTPase KRas | / | 0.580 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.575 | |
| 4obe | GDP | GTPase KRas | / | 0.570 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.569 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.567 | |
| 4lv6 | GDP | GTPase KRas | / | 0.559 | |
| 4wa7 | GDP | GTPase KRas | / | 0.554 | |
| 2rgg | GNP | GTPase HRas | / | 0.552 | |
| 4epw | GDP | GTPase KRas | / | 0.550 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.545 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.544 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.540 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.538 | |
| 2ce2 | GDP | GTPase HRas | / | 0.538 | |
| 3ddc | GNP | GTPase HRas | / | 0.537 | |
| 4xvr | GNP | GTPase HRas | / | 0.537 | |
| 4lrw | GDP | GTPase KRas | / | 0.536 | |
| 3tgp | GNP | GTPase HRas | / | 0.535 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.533 | |
| 3lbh | GNP | GTPase HRas | / | 0.533 | |
| 3v4f | GNP | GTPase HRas | / | 0.532 | |
| 4dlt | GNP | GTPase HRas | / | 0.532 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.532 | |
| 3oiu | GNP | GTPase HRas | / | 0.526 | |
| 4xvq | GNP | GTPase HRas | / | 0.526 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.525 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.525 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.524 | |
| 3oiw | GNP | GTPase HRas | / | 0.522 | |
| 3rs0 | GNP | GTPase HRas | / | 0.522 | |
| 4dsu | GDP | GTPase KRas | / | 0.522 | |
| 1uad | GNP | Ras-related protein Ral-A | / | 0.521 | |
| 2rgb | GNP | GTPase HRas | / | 0.521 | |
| 3i3s | GNP | GTPase HRas | / | 0.521 | |
| 3lbn | GNP | GTPase HRas | / | 0.521 | |
| 3l8y | GNP | GTPase HRas | / | 0.518 | |
| 3k9l | GNP | GTPase HRas | / | 0.517 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.516 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.515 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.515 | |
| 2c5l | GTP | GTPase HRas | / | 0.513 | |
| 3rs4 | GNP | GTPase HRas | / | 0.513 | |
| 3rsl | GNP | GTPase HRas | / | 0.513 | |
| 4dsn | GCP | GTPase KRas | / | 0.513 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.511 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.511 | |
| 2rgc | GNP | GTPase HRas | / | 0.510 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.510 | |
| 3rs5 | GNP | GTPase HRas | / | 0.509 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.508 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.507 | |
| 3kud | GDP | GTPase HRas | / | 0.507 | |
| 3lbi | GNP | GTPase HRas | / | 0.507 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.507 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.507 | |
| 4dlx | GNP | GTPase HRas | / | 0.506 | |
| 4nyi | GNP | GTPase HRas | / | 0.505 | |
| 3oiv | GNP | GTPase HRas | / | 0.504 | |
| 4g0n | GNP | GTPase HRas | / | 0.504 | |
| 4dlw | GNP | GTPase HRas | / | 0.503 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.502 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.501 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.500 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.499 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.499 | |
| 3k8y | GNP | GTPase HRas | / | 0.498 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.497 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.497 | |
| 4dlz | GNP | GTPase HRas | / | 0.496 | |
| 2rge | GNP | GTPase HRas | / | 0.495 | |
| 4mit | GTP | Rho-related protein racC | / | 0.494 | |
| 4nyj | GNP | GTPase HRas | / | 0.494 | |
| 5b2z | GNP | GTPase HRas | / | 0.492 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.491 | |
| 4dso | GSP | GTPase KRas | / | 0.490 | |
| 4k81 | GTP | GTPase HRas | / | 0.490 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.489 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.489 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.488 | |
| 4uj5 | GNP | Ras-related protein Rab-11A | / | 0.488 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.486 | |
| 3rs7 | GNP | GTPase HRas | / | 0.486 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.486 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.485 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.485 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.485 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.485 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.485 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.485 | |
| 1lfd | GNP | GTPase HRas | / | 0.483 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.483 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.483 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.482 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.482 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.481 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.480 | |
| 2cl6 | CAG | GTPase HRas | / | 0.480 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.479 | |
| 1e0j | ANP | DNA primase/helicase | 2.7.7 | 0.478 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.478 | |
| 4dlv | GNP | GTPase HRas | / | 0.478 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 4dls | GNP | GTPase HRas | / | 0.474 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.474 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.473 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.473 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.473 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.472 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.472 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.472 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.472 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.471 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.471 | |
| 1a4r | GNH | Cell division control protein 42 homolog | / | 0.470 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.469 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.469 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.469 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.469 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.469 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.468 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.468 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.468 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.467 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.467 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.466 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.466 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.465 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.465 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.464 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.464 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.464 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.464 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.464 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.464 | |
| 4d0l | GSP | Ras-related protein Rab-11A | / | 0.464 | |
| 4z28 | BTN | Hoefavidin | / | 0.464 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.463 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.463 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.462 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.462 | |
| 1zw1 | TN5 | Enoyl-ACP reductase | / | 0.462 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2p2m | PRX | Acetyl-coenzyme A synthetase | / | 0.462 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.462 | |
| 1g6o | ADP | Cag alpha | / | 0.461 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.461 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.460 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.460 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.460 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.460 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.459 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.459 | |
| 4l9w | GNP | GTPase HRas | / | 0.459 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.458 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.458 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.458 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.458 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.458 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.458 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.458 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.458 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.458 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.457 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.456 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.456 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.456 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.456 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.455 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.455 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.455 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 2vht | ATP | NTPase P4 | / | 0.454 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.454 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.454 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.453 | |
| 2gn4 | UD1 | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.453 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.453 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.453 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.453 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.452 | |
| 1n08 | ADP | Riboflavin kinase | 2.7.1.26 | 0.452 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.452 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.452 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.452 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.452 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.452 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.451 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.451 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.451 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.451 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.451 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.451 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.450 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.450 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.450 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.450 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.449 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.449 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.449 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 3wag | TYD | Glycosyltransferase | / | 0.449 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.448 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.448 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.448 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.448 | |
| 3eku | CY9 | Actin-5C | / | 0.448 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1am4 | GNP | Cell division control protein 42 homolog | / | 0.447 | |
| 1nja | DCM | Thymidylate synthase | / | 0.447 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.447 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.447 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.447 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.447 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.447 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2bxm | IMN | Serum albumin | / | 0.446 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.446 | |
| 2rew | REW | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.446 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.446 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.445 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.445 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.445 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.445 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.445 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.445 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.445 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1j4j | ACO | Acetyltransferase | 2.3.1 | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.444 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2y66 | N04 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4f5d | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 4hi0 | GDP | Urease accessory protein UreG | / | 0.444 | |
| 5a2y | UTP | Mitochondrial poly(A) polymerase | / | 0.444 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1orr | CDP | CDP-paratose 2-epimerase | / | 0.443 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.443 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.443 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2l0x | GDP | GTP-binding protein Rheb | / | 0.443 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.443 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.443 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.443 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.442 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.442 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.442 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 2vo4 | GTB | 2,4-D inducible glutathione S-transferase | / | 0.442 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.442 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4lb2 | DM5 | Serum albumin | / | 0.442 | |
| 4qed | NAP | ElxO | / | 0.442 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.441 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.441 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.441 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.441 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.441 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.441 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.441 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.441 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.440 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.440 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.440 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.440 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.440 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.440 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.440 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.440 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.440 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.440 |