sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4q02 | GDP | GTPase KRas |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4q02 | GDP | GTPase KRas | / | 1.000 | |
| 4epw | GDP | GTPase KRas | / | 0.713 | |
| 4lv6 | GDP | GTPase KRas | / | 0.658 | |
| 4l8g | GDP | GTPase KRas | / | 0.649 | |
| 3k9l | GNP | GTPase HRas | / | 0.648 | |
| 4ldj | GDP | GTPase KRas | / | 0.645 | |
| 4luc | GDP | GTPase KRas | / | 0.639 | |
| 4epx | GDP | GTPase KRas | / | 0.638 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.630 | |
| 4l9s | GDP | GTPase HRas | / | 0.627 | |
| 4tq9 | GDP | GTPase KRas | / | 0.627 | |
| 4obe | GDP | GTPase KRas | / | 0.625 | |
| 4q03 | GDP | GTPase KRas | / | 0.623 | |
| 4lpk | GDP | GTPase KRas | / | 0.617 | |
| 4ql3 | GDP | GTPase KRas | / | 0.615 | |
| 4wa7 | GDP | GTPase KRas | / | 0.610 | |
| 4lrw | GDP | GTPase KRas | / | 0.609 | |
| 4xvq | GNP | GTPase HRas | / | 0.602 | |
| 3tgp | GNP | GTPase HRas | / | 0.600 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.599 | |
| 2rgg | GNP | GTPase HRas | / | 0.597 | |
| 1lfd | GNP | GTPase HRas | / | 0.590 | |
| 2ce2 | GDP | GTPase HRas | / | 0.586 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.582 | |
| 4xvr | GNP | GTPase HRas | / | 0.579 | |
| 3i3s | GNP | GTPase HRas | / | 0.578 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.578 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.575 | |
| 4nyj | GNP | GTPase HRas | / | 0.573 | |
| 1uad | GNP | Ras-related protein Ral-A | / | 0.572 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.568 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.559 | |
| 4dsu | GDP | GTPase KRas | / | 0.558 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.557 | |
| 2c5l | GTP | GTPase HRas | / | 0.557 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.557 | |
| 2rge | GNP | GTPase HRas | / | 0.556 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.555 | |
| 3rs5 | GNP | GTPase HRas | / | 0.555 | |
| 4nyi | GNP | GTPase HRas | / | 0.554 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.553 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.552 | |
| 3rs4 | GNP | GTPase HRas | / | 0.552 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.551 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.550 | |
| 3ddc | GNP | GTPase HRas | / | 0.550 | |
| 3oiv | GNP | GTPase HRas | / | 0.548 | |
| 3lbh | GNP | GTPase HRas | / | 0.546 | |
| 3v4f | GNP | GTPase HRas | / | 0.544 | |
| 4dlv | GNP | GTPase HRas | / | 0.544 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.543 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.541 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.541 | |
| 4k81 | GTP | GTPase HRas | / | 0.541 | |
| 3l8y | GNP | GTPase HRas | / | 0.540 | |
| 5b2z | GNP | GTPase HRas | / | 0.540 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.539 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.537 | |
| 3oiu | GNP | GTPase HRas | / | 0.537 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.536 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.535 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.534 | |
| 4dlx | GNP | GTPase HRas | / | 0.533 | |
| 4dlz | GNP | GTPase HRas | / | 0.532 | |
| 2rgc | GNP | GTPase HRas | / | 0.530 | |
| 4dsn | GCP | GTPase KRas | / | 0.530 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.530 | |
| 3rs7 | GNP | GTPase HRas | / | 0.528 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.526 | |
| 3rsl | GNP | GTPase HRas | / | 0.526 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.525 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.525 | |
| 2cl6 | CAG | GTPase HRas | / | 0.524 | |
| 3lbn | GNP | GTPase HRas | / | 0.524 | |
| 2l0x | GDP | GTP-binding protein Rheb | / | 0.523 | |
| 4uj5 | GNP | Ras-related protein Rab-11A | / | 0.523 | |
| 3oiw | GNP | GTPase HRas | / | 0.522 | |
| 4dls | GNP | GTPase HRas | / | 0.522 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.520 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.520 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.520 | |
| 3lbi | GNP | GTPase HRas | / | 0.519 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.519 | |
| 4dlw | GNP | GTPase HRas | / | 0.519 | |
| 3k8y | GNP | GTPase HRas | / | 0.516 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.515 | |
| 3rs0 | GNP | GTPase HRas | / | 0.515 | |
| 4dlt | GNP | GTPase HRas | / | 0.514 | |
| 2rgb | GNP | GTPase HRas | / | 0.513 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.512 | |
| 3kud | GDP | GTPase HRas | / | 0.511 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.510 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.510 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.509 | |
| 4l9w | GNP | GTPase HRas | / | 0.509 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.508 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.506 | |
| 2iut | AGS | DNA translocase FtsK | / | 0.504 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.503 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.503 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.502 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.502 | |
| 4g0n | GNP | GTPase HRas | / | 0.502 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.501 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.500 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.500 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.499 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.497 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.497 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.494 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.493 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.491 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.490 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.490 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.490 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.490 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.490 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.489 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.488 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.487 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.486 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.485 | |
| 3tnf | GNP | Ras-related protein Rab-8A | / | 0.484 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.484 | |
| 1a4r | GNH | Cell division control protein 42 homolog | / | 0.483 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.483 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.483 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.482 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.481 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.481 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.481 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.481 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.480 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.479 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.479 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.478 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.477 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.477 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.477 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.476 | |
| 2ic5 | GNP | Ras-related C3 botulinum toxin substrate 3 | / | 0.476 | |
| 4dso | GSP | GTPase KRas | / | 0.475 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.474 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.474 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.474 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.474 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.474 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.473 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.473 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.472 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.472 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.472 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.472 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.472 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.472 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.472 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.472 | |
| 4d0l | GSP | Ras-related protein Rab-11A | / | 0.472 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.471 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.471 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.471 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.471 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.471 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.471 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.471 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.471 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.470 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.469 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.468 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.468 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.467 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.466 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.466 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.466 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.466 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.466 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.466 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.466 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.466 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.466 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.465 | |
| 1nja | DCM | Thymidylate synthase | / | 0.465 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.465 | |
| 1r2j | FAD | FkbI | / | 0.465 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.465 | |
| 2mse | GNP | MHC class I alpha chain | / | 0.465 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.465 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.465 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.465 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.465 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.464 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.464 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.464 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.464 | |
| 1e0j | ANP | DNA primase/helicase | 2.7.7 | 0.463 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.463 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.463 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.463 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.462 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.462 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.462 | |
| 4y0v | GDP | ADP-ribosylation factor 1, putative | / | 0.462 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.461 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.461 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.461 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.461 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.461 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.461 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.461 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.461 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.461 | |
| 4jdc | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.461 | |
| 4o4f | ATP | Kinase | / | 0.461 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.460 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.460 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.460 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.460 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.460 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4wbn | GTP | Tubulin alpha-1B chain | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.459 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.459 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.459 | |
| 3kro | IPE | Geranyl diphosphate synthase large subunit | / | 0.459 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.459 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.459 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.459 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.459 | |
| 4mit | GTP | Rho-related protein racC | / | 0.459 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.459 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.459 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.458 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.458 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.458 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4eb4 | UMP | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.458 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.458 | |
| 1f9a | ATP | Nicotinamide-nucleotide adenylyltransferase | / | 0.457 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.457 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.457 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.457 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.457 | |
| 3cgy | RDC | Virulence sensor histidine kinase PhoQ | 2.7.13.3 | 0.457 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.457 | |
| 1ii6 | ADP | Kinesin-like protein KIF11 | / | 0.456 | |
| 1jmf | UMP | Thymidylate synthase | / | 0.456 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.456 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.456 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.456 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.456 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.456 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.456 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.456 | |
| 4g01 | GDP | Ras-related protein RABF2b | / | 0.456 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.456 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.456 | |
| 4ubu | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.456 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.456 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.456 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.455 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.455 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.455 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.455 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.455 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4hi0 | GDP | Urease accessory protein UreG | / | 0.455 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4u2s | FDA | Cholesterol oxidase | 1.1.3.6 | 0.455 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.455 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.455 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.454 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.454 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.454 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.454 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.454 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.454 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.454 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.454 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.454 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.454 | |
| 5ez4 | NAD | Betaine-aldehyde dehydrogenase | / | 0.454 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.453 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.453 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.453 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.453 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.453 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.453 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.453 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.453 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.453 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.453 | |
| 4v12 | POG | MaoC like domain protein | / | 0.453 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.452 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.452 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.452 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.452 | |
| 3eku | CY9 | Actin-5C | / | 0.452 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.452 | |
| 3fhi | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3moh | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.452 | |
| 3up0 | D7S | aceDAF-12 | / | 0.452 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4xr9 | NAD | CalS8 | / | 0.452 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.452 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.451 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.451 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.451 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.451 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.451 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.451 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.451 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.451 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4itr | GDP | Cell division control protein 42 homolog | / | 0.451 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.451 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.451 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.450 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.450 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.450 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.450 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.450 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.450 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.450 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.450 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.450 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.450 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.449 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.449 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.449 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.449 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4h5c | YS4 | Farnesyl pyrophosphate synthase | 2.5.1.10 | 0.449 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 4ihj | GTP | Tubulin alpha-1B chain | / | 0.449 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.449 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.449 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.449 | |
| 5iot | UMP | Flavin-dependent thymidylate synthase | 2.1.1.148 | 0.449 | |
| 1u1i | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.448 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.448 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1xow | R18 | Androgen receptor | / | 0.448 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2g0l | FLN | Neocarzinostatin | / | 0.448 | |
| 2g8d | UMP | Thymidylate synthase | / | 0.448 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.448 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.448 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.448 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.448 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.448 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.448 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.448 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.447 | |
| 2az3 | CDP | Nucleoside diphosphate kinase | / | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.447 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.447 | |
| 3bc1 | GNP | Ras-related protein Rab-27A | / | 0.447 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 4ag5 | ADP | Type IV secretory pathway VirB4 components-like protein | / | 0.447 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.447 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.447 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.447 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.447 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.447 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.447 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.446 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.446 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.446 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3qgd | 26S | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.446 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.446 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.446 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.446 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.446 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.446 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.445 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.445 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.445 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1vq1 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.445 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2bgj | FAD | NADPH:ferredoxin reductase | / | 0.445 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.445 | |
| 2h2j | SFG | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.445 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 2r9e | SDX | Citrate synthase | 2.3.3.16 | 0.445 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.445 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3rga | ILD | Epoxide hydrolase LasB | 5.5.1 | 0.445 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.445 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.445 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.445 | |
| 4bix | ADP | Sensor histidine kinase CpxA | / | 0.445 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.445 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.444 | |
| 1g6o | ADP | Cag alpha | / | 0.444 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1onp | FOM | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.444 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.444 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 2d4h | 5GP | Guanylate-binding protein 1 | / | 0.444 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.444 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.444 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3l5e | BDW | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.444 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3t7v | SAM | 3-methylornithine synthase | / | 0.444 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 4cf8 | V7H | Integrase | / | 0.444 | |
| 4j49 | 1J1 | Uncharacterized protein | / | 0.444 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.444 | |
| 4u7w | NDP | MxaA | / | 0.444 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.444 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.444 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.443 | |
| 1lcw | SHM | Streptavidin | / | 0.443 | |
| 1lwx | AZD | Nucleoside diphosphate kinase, cytosolic | 2.7.4.6 | 0.443 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.443 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.443 | |
| 2fdu | D1G | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 2p2m | PRX | Acetyl-coenzyme A synthetase | / | 0.443 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3zdf | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.443 | |
| 4b1f | KRH | Glutamate racemase | / | 0.443 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.443 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.443 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.443 | |
| 4qbi | AP5 | Adenylate kinase | / | 0.443 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.443 | |
| 4ypu | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.443 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1gvh | FAD | Flavohemoprotein | / | 0.442 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.442 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.442 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2fjn | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.442 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.442 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.442 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.442 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.442 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3iej | 599 | Cathepsin S | 3.4.22.27 | 0.442 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 3q0u | LL3 | HTH-type transcriptional regulator EthR | / | 0.442 | |
| 3vrb | FTN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.442 | |
| 3vrb | FTN | Cytochrome b-large subunit | / | 0.442 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.442 | |
| 4ho4 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.442 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 4pkw | GM6 | Lethal factor | 3.4.24.83 | 0.442 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.442 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.442 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.442 | |
| 5iqf | GDP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.441 | |
| 1euy | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.441 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.441 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.441 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.441 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.441 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.441 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.441 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.441 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2wvl | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.441 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.441 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.441 | |
| 3lns | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.441 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.441 | |
| 4fvr | ATP | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.441 | |
| 4u0z | APC | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.441 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 4zol | GTP | Tubulin alpha-1B chain | / | 0.441 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.441 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.441 | |
| 5epo | TUD | 7-alpha-hydroxysteroid deydrogenase | / | 0.441 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.440 | |
| 1hk4 | T44 | Serum albumin | / | 0.440 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.440 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.440 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2wp5 | FAD | Trypanothione reductase | / | 0.440 | |
| 2wpw | ACO | Orf14 | / | 0.440 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.440 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.440 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.440 | |
| 3zv6 | 4HB | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.440 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.440 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.440 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4o4e | ATP | Kinase | / | 0.440 | |
| 4oi4 | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.440 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.440 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.440 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.440 |