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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4psgNOHThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4psgNOHThymidylate synthase/1.000
4irrUMPThymidylate synthase/0.606
3qj7UMPThymidylate synthase ThyA/0.588
4h0uUMPThymidylate synthase/0.585
4eb4UMPThymidylate synthase2.1.1.450.582
4e5oUMPThymidylate synthase2.1.1.450.564
5by6UMPThymidylate synthase/0.560
4xsdUMPThymidylate synthase2.1.1.450.552
1bidUMPThymidylate synthase/0.550
1ci7UMPThymidylate synthase2.1.1.450.546
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.538
3hb8UMPThymidylate synthase2.1.1.450.535
4einNOHThymidylate synthase2.1.1.450.531
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.530
1jmgUMPThymidylate synthase/0.525
1njbUMPThymidylate synthase/0.519
1aobDDUThymidylate synthase/0.517
4dq1UMPThymidylate synthase/0.517
1tsxUMPThymidylate synthase/0.515
2g86UMPThymidylate synthase/0.514
1njaDCMThymidylate synthase/0.513
4iqqUMPThymidylate synthase/0.512
2g89UMPThymidylate synthase/0.503
1bduDURThymidylate synthase/0.500
3bgxTMPThymidylate synthase/0.492
1njeDCMThymidylate synthase/0.491
2vetUMPThymidylate synthase/0.489
1bp6UMPThymidylate synthase/0.487
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.486
1tsvUMPThymidylate synthase/0.485
2g8aUMPThymidylate synthase/0.483
1dduDDUThymidylate synthase/0.482
1njdUMPThymidylate synthase/0.478
1jmhUMPThymidylate synthase/0.475
1lcbTMPThymidylate synthase/0.473
1jmiUMPThymidylate synthase/0.470
1tsyUMPThymidylate synthase/0.464
1njcDCMThymidylate synthase/0.462
2getCOKPantothenate kinase2.7.1.330.461
1jmfUMPThymidylate synthase/0.457
2tsrUMPThymidylate synthase2.1.1.450.453
2tdmUMPThymidylate synthase/0.452
4iskUMPThymidylate synthase/0.450
2g8dUMPThymidylate synthase/0.448
1bpjUMPThymidylate synthase/0.447
1vzaUMPThymidylate synthase/0.447
4lrrCF9Thymidylate synthase/0.447
1tqf32PBeta-secretase 13.4.23.460.443
1tduDURThymidylate synthase/0.442
1tysTMPThymidylate synthase/0.440
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.440
4ihl1F514-3-3 protein zeta/delta/0.440