scPDB - Distribution of Binding site Similarity values of 4pnr entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4pnr	G18	Tankyrase-2	2.4.2.30

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4pnr	G18	Tankyrase-2	2.4.2.30	1.000
4tkg	09L	Tankyrase-2	2.4.2.30	0.645
4krs	1SX	Tankyrase-1	2.4.2.30	0.623
4hlm	16S	Tankyrase-2	2.4.2.30	0.580
4l32	1VF	Tankyrase-2	2.4.2.30	0.580
4l33	F70	Tankyrase-2	2.4.2.30	0.580
4pnm	NU1	Tankyrase-2	2.4.2.30	0.580
4buf	F36	Tankyrase-2	2.4.2.30	0.579
4iue	AJ4	Tankyrase-2	2.4.2.30	0.576
4bux	F35	Tankyrase-2	2.4.2.30	0.573
4hkk	AGI	Tankyrase-2	2.4.2.30	0.570
4msk	2C8	Tankyrase-1	2.4.2.30	0.570
4bj9	UHB	Tankyrase-2	2.4.2.30	0.567
4l2f	1V3	Tankyrase-2	2.4.2.30	0.566
4avw	G18	Tankyrase-2	2.4.2.30	0.561
4hlf	15Z	Tankyrase-2	2.4.2.30	0.561
4l0t	1V0	Tankyrase-2	2.4.2.30	0.561
4hlh	20D	Tankyrase-2	2.4.2.30	0.560
4l0i	1UW	Tankyrase-2	2.4.2.30	0.560
4bue	JQF	Tankyrase-2	2.4.2.30	0.559
4j3m	AJ8	Tankyrase-2	2.4.2.30	0.559
4l31	F08	Tankyrase-2	2.4.2.30	0.559
4tjy	3GN	Tankyrase-2	2.4.2.30	0.554
4bu9	08C	Tankyrase-2	2.4.2.30	0.553
3kr8	XAV	Tankyrase-2	2.4.2.30	0.552
4j22	AJ7	Tankyrase-2	2.4.2.30	0.551
4buw	F33	Tankyrase-2	2.4.2.30	0.550
4hl5	15W	Tankyrase-2	2.4.2.30	0.543
4l2k	1V8	Tankyrase-2	2.4.2.30	0.543
4bjb	P34	Tankyrase-2	2.4.2.30	0.540
3p0p	NNF	Tankyrase-2	2.4.2.30	0.539
4kzu	A73	Tankyrase-2	2.4.2.30	0.539
4but	31F	Tankyrase-2	2.4.2.30	0.535
4hmh	F94	Tankyrase-2	2.4.2.30	0.535
4kzl	20D	Tankyrase-2	2.4.2.30	0.535
4buu	F38	Tankyrase-2	2.4.2.30	0.534
4l0s	1UZ	Tankyrase-2	2.4.2.30	0.534
4bud	29F	Tankyrase-2	2.4.2.30	0.533
4j21	AJ6	Tankyrase-2	2.4.2.30	0.531
4hkn	LU2	Tankyrase-2	2.4.2.30	0.530
4l34	1VG	Tankyrase-2	2.4.2.30	0.528
4l10	A63	Tankyrase-2	2.4.2.30	0.527
4hlg	20B	Tankyrase-2	2.4.2.30	0.516
4bus	32F	Tankyrase-2	2.4.2.30	0.515
4l0v	1V1	Tankyrase-2	2.4.2.30	0.515
4l09	1UR	Tankyrase-2	2.4.2.30	0.514
5aku	29F	Tankyrase-2	2.4.2.30	0.513
4bui	W2E	Tankyrase-2	2.4.2.30	0.510
4hlk	431	Tankyrase-2	2.4.2.30	0.508
4l2g	1V4	Tankyrase-2	2.4.2.30	0.508
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.506
1xk9	P34	Exotoxin A	2.4.2.36	0.503
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.503
4i9i	1DY	Tankyrase-1	2.4.2.30	0.497
4gv7	MEW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.496
1uk0	FRM	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.494
4hki	FLN	Tankyrase-2	2.4.2.30	0.492
4li6	1XO	Tankyrase-1	2.4.2.30	0.491
4bs4	A64	Tankyrase-2	2.4.2.30	0.490
2zit	NAD	Exotoxin A	2.4.2.36	0.489
4gv2	5ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.489
3b8h	NAD	Exotoxin A	2.4.2.36	0.487
2rd6	78P	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.483
4bjc	RPB	Tankyrase-2	2.4.2.30	0.482
4tvj	09L	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.482
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.481
3b78	NAD	Exotoxin A	2.4.2.36	0.480
3gn7	3GN	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.480
4hyf	1AK	Tankyrase-2	2.4.2.30	0.478
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.476
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.475
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.472
4buv	16I	Tankyrase-2	2.4.2.30	0.471
1xf0	ASD	Aldo-keto reductase family 1 member C3	/	0.468
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.468
4li7	1XP	Tankyrase-1	2.4.2.30	0.468
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.467
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.467
4hhy	15R	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.467
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.466
4l6s	1WQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.464
2gev	COK	Pantothenate kinase	2.7.1.33	0.463
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.463
3vg9	ZMA	Adenosine receptor A2a	/	0.462
2e9a	B28	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.461
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.460
2zsd	COA	Pantothenate kinase	2.7.1.33	0.458
3gey	P34	Poly [ADP-ribose] polymerase 15	2.4.2.30	0.458
4gv4	MEJ	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.458
1h35	R01	Squalene--hopene cyclase	4.2.1.129	0.457
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.457
4fcb	0T7	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.457
4r5w	XAV	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.457
2c1z	KMP	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.456
1xor	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.455
4rel	KMP	Glycosyltransferase	/	0.455
4avu	LDR	Tankyrase-2	2.4.2.30	0.454
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.453
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.452
1so2	666	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.452
3ce0	P34	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.452
4z87	GDP	Inosine-5'-monophosphate dehydrogenase	/	0.452
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.451
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.449
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.449
1uk1	FRQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.449
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.449
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.449
4hkf	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.449
1oj4	CDM	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	2.7.1.148	0.448
3a1l	2CC	Cytochrome P450	/	0.448
3qpo	PFR	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.448
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.447
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.447
4nbj	D3Y	D-tyrosyl-tRNA(Tyr) deacylase	/	0.447
2wsa	646	Glycylpeptide N-tetradecanoyltransferase	/	0.446
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.446
3g70	A5T	Renin	3.4.23.15	0.446
3i28	34N	Bifunctional epoxide hydrolase 2	3.3.2.10	0.446
1yry	MSG	Purine nucleoside phosphorylase	2.4.2.1	0.445
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.445
4e32	DWN	Methyltransferase	/	0.445
4f0e	0RU	Poly [ADP-ribose] polymerase 15	2.4.2.30	0.445
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.444
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.444
2e99	B08	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.444
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.444
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.444
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
4jlk	1NO	Deoxycytidine kinase	2.7.1.74	0.444
5dp2	NAP	CurF	/	0.444
2get	COK	Pantothenate kinase	2.7.1.33	0.443
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.443
3dyn	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
3g4g	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.443
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.442
3u9f	CLM	Chloramphenicol acetyltransferase	2.3.1.28	0.442
3wd9	QPC	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.442
3zei	AWH	O-acetylserine sulfhydrylase	/	0.442
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.442
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.441
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
4kw5	1W6	Decaprenylphosphoryl-beta-D-ribose oxidase	/	0.441
4n4v	2GY	Tankyrase-1	2.4.2.30	0.441
1y2d	4DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
2ovy	PFJ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440