scPDB - Distribution of Binding site Similarity values of 4pnm entry / Site 4

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4pnm	NU1	Tankyrase-2	2.4.2.30

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4pnm	NU1	Tankyrase-2	2.4.2.30	1.000
4bj9	UHB	Tankyrase-2	2.4.2.30	0.597
4tjy	3GN	Tankyrase-2	2.4.2.30	0.574
4li6	1XO	Tankyrase-1	2.4.2.30	0.538
4mt9	2D6	Tankyrase-1	2.4.2.30	0.538
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.536
4bjb	P34	Tankyrase-2	2.4.2.30	0.535
4hyf	1AK	Tankyrase-2	2.4.2.30	0.516
4li7	1XP	Tankyrase-1	2.4.2.30	0.516
4tkg	09L	Tankyrase-2	2.4.2.30	0.509
4li8	1XQ	Tankyrase-1	2.4.2.30	0.505
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.495
4pnr	G18	Tankyrase-2	2.4.2.30	0.490
4tvj	09L	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.490
4i9i	1DY	Tankyrase-1	2.4.2.30	0.481
1uk1	FRQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.479
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.477
1xk9	P34	Exotoxin A	2.4.2.36	0.475
4l32	1VF	Tankyrase-2	2.4.2.30	0.475
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.474
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.473
4hkk	AGI	Tankyrase-2	2.4.2.30	0.473
5dsy	UHB	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.473
1c7o	PPG	Hemolysin	/	0.468
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.468
2rd6	78P	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.466
4jqh	1MF	Alr2278 protein	/	0.466
5ds3	09L	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.465
3b82	NAD	Exotoxin A	2.4.2.36	0.464
2zit	NAD	Exotoxin A	2.4.2.36	0.463
4l33	F70	Tankyrase-2	2.4.2.30	0.462
2wsa	646	Glycylpeptide N-tetradecanoyltransferase	/	0.461
4iue	AJ4	Tankyrase-2	2.4.2.30	0.461
4l6s	1WQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.461
3qm4	PN0	Cytochrome P450 2D6	/	0.460
4hlf	15Z	Tankyrase-2	2.4.2.30	0.460
4j21	AJ6	Tankyrase-2	2.4.2.30	0.460
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.459
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.459
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.459
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.459
4r5w	XAV	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.459
2rcw	AAI	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.458
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.458
1x8l	OXR	Retinol dehydratase	/	0.454
2jbs	FMN	p-hydroxyphenylacetate 3-hydroxylase, oxygenase component	/	0.454
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.454
5c6c	CMP	cGMP-dependent protein kinase 2	2.7.11.12	0.454
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.453
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.453
3tda	PN0	Cytochrome P450 2D6	/	0.453
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.453
1qti	GNT	Acetylcholinesterase	3.1.1.7	0.452
1uk0	FRM	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.450
4a32	2CD	Glycylpeptide N-tetradecanoyltransferase	/	0.450
4ryv	ZEA	Protein LlR18A	/	0.450
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.449
4wx2	F6F	Tryptophan synthase alpha chain	/	0.449
4wx2	F6F	Tryptophan synthase beta chain	4.2.1.20	0.449
3kr8	XAV	Tankyrase-2	2.4.2.30	0.448
3zku	HCV	Isopenicillin N synthase	1.21.3.1	0.448
4krs	1SX	Tankyrase-1	2.4.2.30	0.448
3ce0	P34	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.447
4avw	G18	Tankyrase-2	2.4.2.30	0.447
4bux	F35	Tankyrase-2	2.4.2.30	0.447
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
2j3j	HC4	NADPH-dependent oxidoreductase 2-alkenal reductase	1.3.1.74	0.446
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.446
3hxf	BD9	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.445
4bfs	ZVS	Pantothenate kinase	2.7.1.33	0.445
4c2z	646	Glycylpeptide N-tetradecanoyltransferase 1	/	0.445
4heu	15J	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.445
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.445
1xor	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
2uag	UMA	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.444
3v0o	4GW	Histo-blood group ABO system transferase	/	0.444
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.444
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.443
4iah	1DX	Alr2278 protein	/	0.443
4j22	AJ7	Tankyrase-2	2.4.2.30	0.443
1d3p	BT3	Prothrombin	3.4.21.5	0.442
2fap	RAD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.442
2fap	RAD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.442
3hxe	BD8	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.442
4azy	7F3	Beta-secretase 1	3.4.23.46	0.442
4l0i	1UW	Tankyrase-2	2.4.2.30	0.442
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.441
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
4l7j	1W2	Beta-secretase 1	3.4.23.46	0.441
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.440
1zdw	FLV	Prenyltransferase	/	0.440
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.440
4fcb	0T7	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440