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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4pkhADPActin, alpha skeletal muscle

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4pkhADPActin, alpha skeletal muscle/1.000
1lotATPActin, alpha skeletal muscle/0.622
4k42ADPActin, alpha skeletal muscle/0.607
2q36ATPActin, alpha skeletal muscle/0.596
3m6gATPActin, alpha skeletal muscle/0.584
1c0fATPMajor actin/0.574
5ce3ATPActin/0.574
1s22ATPActin, alpha skeletal muscle/0.573
3a5mATPMajor actin/0.572
4pkgATPActin, alpha skeletal muscle/0.567
3mn6ATPActin-5C/0.564
3tu5ATPActin, alpha skeletal muscle/0.563
4pkiATPActin, alpha skeletal muscle/0.562
4pl8ATPActin, alpha skeletal muscle/0.559
2v51ATPActin, alpha skeletal muscle/0.557
4ci6ATPActin/0.549
4m63ATPActin-5C/0.548
1h1vATPActin, alpha skeletal muscle/0.547
3u9dATPActin, alpha skeletal muscle/0.544
1qz5ATPActin, alpha skeletal muscle/0.543
1t44ATPActin, alpha skeletal muscle/0.537
1mduATPActin, alpha skeletal muscle/0.536
1kxpATPActin, alpha skeletal muscle/0.534
3el2ATPActin-5C/0.532
4cbxATPActin-2/0.532
1ijjATPActin, alpha skeletal muscle/0.531
1rgiATPActin, alpha skeletal muscle/0.531
4jhdANPActin-5C/0.531
3mn9ATPActin-5C/0.528
1nmdATPMajor actin/0.527
2q97ATPActin, alpha skeletal muscle/0.521
1eqyATPActin, alpha skeletal muscle/0.510
1yxqATPActin, alpha skeletal muscle/0.507
3m1fATPActin, alpha skeletal muscle/0.507
4rwtANPActin-5C/0.507
3a5oATPMajor actin/0.505
3u4lATPActin, cytoplasmic 1/0.505
1nm1ATPMajor actin/0.503
2p9kATPActin-related protein 2/0.503
4k41ATPActin, alpha skeletal muscle/0.502
3ffkATPActin, alpha skeletal muscle/0.501
3w3dATPActin, gamma-enteric smooth muscle/0.497
4k43ADPActin, alpha skeletal muscle/0.485
3mn7ATPActin-5C/0.480
2a41ATPActin, alpha skeletal muscle/0.479
1dejATPMajor actin/0.474
2oanATPActin, cytoplasmic 1/0.470
3dawATPActin, alpha skeletal muscle/0.467
3eksATPActin-5C/0.463
3ekuATPActin-5C/0.461
3chwATPMajor actin/0.446