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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4phlPILPhosphodiesterase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4phlPILPhosphodiesterase/1.000
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.516
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.499
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.491
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.481
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.481
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3v94WYQPhosphodiesterase/0.469
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440