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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4otiMI1Serine/threonine-protein kinase N1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4otiMI1Serine/threonine-protein kinase N1/1.000
3ncz3NCRho-associated protein kinase 12.7.11.10.521
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.497
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.490
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.486
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.486
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4l9i8PRRhodopsin kinase/0.475
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.474
2etrY27Rho-associated protein kinase 12.7.11.10.473
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4e6d0NUTyrosine-protein kinase JAK2/0.471
3t8oATPRhodopsin kinase/0.470
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.467
1g5sI17Cyclin-dependent kinase 22.7.11.220.466
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4ic7ANPMitogen-activated protein kinase 72.7.11.240.464
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2j0m4STFocal adhesion kinase 12.7.10.20.462
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.458
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.457
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3qp0NI8Gag-Pol polyprotein3.4.23.160.457
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.456
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2ijmADPFocal adhesion kinase 12.7.10.20.454
1jklANPDeath-associated protein kinase 12.7.11.10.453
3nynSGVG protein-coupled receptor kinase 62.7.11.160.453
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.453
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4hge15VTyrosine-protein kinase JAK2/0.451
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
1ykr628Cyclin-dependent kinase 22.7.11.220.450
2vu3LZECyclin-dependent kinase 22.7.11.220.450
3gu7ADPDeath-associated protein kinase 12.7.11.10.450
1oitHDTCyclin-dependent kinase 22.7.11.220.449
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
5av2KMPDeath-associated protein kinase 12.7.11.10.449
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.447
3lfqA28Cyclin-dependent kinase 22.7.11.220.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.447
4dtaADNAPH(2'')-Id/0.446
2cciATPCyclin-dependent kinase 22.7.11.220.445
3ezvEZVCyclin-dependent kinase 22.7.11.220.445
3nwq2NCGag-Pol polyprotein3.4.23.160.445
2w05FRTCyclin-dependent kinase 22.7.11.220.444
3el51UNGag-Pol polyprotein/0.443
3lpbNVBTyrosine-protein kinase JAK2/0.443
3qbfJHGGag-Pol polyprotein3.4.23.160.443
3w33W19Epidermal growth factor receptor2.7.10.10.443
4eooATPCyclin-dependent kinase 22.7.11.220.443
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
2f2uM77Rho-associated protein kinase 22.7.11.10.442
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4hvi19STyrosine-protein kinase JAK32.7.10.20.442
4j95ACPFibroblast growth factor receptor 2/0.442
1t7j478Gag-Pol polyprotein3.4.23.160.441
2qnqQN3Gag-Pol polyprotein3.4.23.160.441
3c4wATPRhodopsin kinase/0.441
3s1h56ZCyclin-dependent kinase 22.7.11.220.441
3w2sW2REpidermal growth factor receptor2.7.10.10.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
1yt9OISGag-Pol polyprotein/0.440
2fxdDR7Pol polyprotein/0.440
3a8wATPProtein kinase C iota type2.7.11.130.440
3c4zADPRhodopsin kinase/0.440
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.440