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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ot2NPSSerum albumin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ot2NPSSerum albumin/1.000
2bxgIBPSerum albumin/0.558
4zbrNPSSerum albumin/0.547
2bxe1FLSerum albumin/0.488
3nwyGTPUridylate kinase/0.459
3lb8FADPutidaredoxin reductase1.18.1.50.454
4z34ON7Lysophosphatidic acid receptor 1/0.454
3tqhNDPQuinone oxidoreductase/0.450
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.448
4fhi0S4Vitamin D3 receptor A/0.448
2p4yC03Peroxisome proliferator-activated receptor gamma/0.447
1s0zEB1Vitamin D3 receptor/0.446
2zbzVDXVitamin D3 dihydroxylase/0.444
3v9y24LPeroxisome proliferator-activated receptor gamma/0.444
4hge15VTyrosine-protein kinase JAK2/0.444
4pytFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
2ad5ADPCTP synthase/0.443
2w2lNADD-mandelate dehydrogenase/0.443
1xq6NAPUncharacterized protein At5g02240/0.442
2j7t274Serine/threonine-protein kinase 102.7.11.10.442
4b7dQLECytochrome P450 monooxygenase PikC/0.442
4b8zNAPGDP-L-fucose synthase1.1.1.2710.442
1tllNAPNitric oxide synthase, brain1.14.13.390.441
1txiTX5Vitamin D3 receptor/0.441
1ybmNAPUncharacterized protein At5g02240/0.441
4nmdFDABifunctional protein PutA/0.441