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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4obeGDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4obeGDPGTPase KRas/1.000
4tq9GDPGTPase KRas/0.665
4epwGDPGTPase KRas/0.647
4q02GDPGTPase KRas/0.637
3kkqGDPRas-related protein M-Ras/0.630
4l9sGDPGTPase HRas/0.624
4epxGDPGTPase KRas/0.622
4ql3GDPGTPase KRas/0.619
4q03GDPGTPase KRas/0.616
4ldjGDPGTPase KRas/0.611
4hdqGNPRas-related protein Rap-1b/0.610
4l8gGDPGTPase KRas/0.610
2fe4GDPRas-related protein Rab-6B/0.608
4lpkGDPGTPase KRas/0.605
4lrwGDPGTPase KRas/0.594
4lv6GDPGTPase KRas/0.594
3tgpGNPGTPase HRas/0.591
4xvqGNPGTPase HRas/0.591
3cphGDPRas-related protein SEC4/0.586
4lucGDPGTPase KRas/0.586
3ddcGNPGTPase HRas/0.581
2rggGNPGTPase HRas/0.580
2bmeGNPRas-related protein Rab-4A/0.579
3qbtGNPRas-related protein Rab-8A/0.578
1x1rGDPRas-related protein M-Ras/0.577
4o2rGDPGTP-binding protein Rheb/0.577
4wa7GDPGTPase KRas/0.576
4xvrGNPGTPase HRas/0.576
5b2zGNPGTPase HRas/0.576
3tsoGNPRas-related protein Rab-25/0.575
1uadGNPRas-related protein Ral-A/0.574
2ce2GDPGTPase HRas/0.573
3x1wGDPRas-related protein Rap-1b/0.573
4nyiGNPGTPase HRas/0.573
3kkoGNPRas-related protein M-Ras/0.570
3lbnGNPGTPase HRas/0.569
3rs4GNPGTPase HRas/0.568
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.567
2rgeGNPGTPase HRas/0.567
2fg5GNPRas-related protein Rab-31/0.566
3mjhGTPRas-related protein Rab-5A/0.565
3i3sGNPGTPase HRas/0.564
2rgbGNPGTPase HRas/0.563
3rslGNPGTPase HRas/0.563
4dlsGNPGTPase HRas/0.563
3lbhGNPGTPase HRas/0.561
3l8yGNPGTPase HRas/0.560
3k9lGNPGTPase HRas/0.558
4g0nGNPGTPase HRas/0.557
5dhaGNPGTP-binding nuclear protein Ran/0.556
1n6lGTPRas-related protein Rab-5A/0.555
3lbiGNPGTPase HRas/0.555
3rs0GNPGTPase HRas/0.554
3x1zGNPRas-related protein Rap-1b/0.553
3pitGNPRas-related protein M-Ras/0.550
3rs5GNPGTPase HRas/0.550
3oivGNPGTPase HRas/0.549
3v4fGNPGTPase HRas/0.549
1lfdGNPGTPase HRas/0.548
3kudGDPGTPase HRas/0.548
2rgcGNPGTPase HRas/0.547
4dlvGNPGTPase HRas/0.547
4dsnGCPGTPase KRas/0.547
3k8yGNPGTPase HRas/0.544
1xtsGTPGTP-binding protein Rheb/0.543
4dlzGNPGTPase HRas/0.543
4nyjGNPGTPase HRas/0.543
2c5lGTPGTPase HRas/0.542
2mscGDPMHC class I alpha chain/0.542
4lhwGNPRas-related protein Rab-8A/0.542
4qxaGTPRas-related protein Rab-9A/0.540
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.538
3oiuGNPGTPase HRas/0.538
3rs7GNPGTPase HRas/0.538
4uj5GNPRas-related protein Rab-11A/0.538
5difGNPGTP-binding nuclear protein Ran/0.538
4k81GTPGTPase HRas/0.536
1g16GDPRas-related protein SEC4/0.534
4dltGNPGTPase HRas/0.534
1yu9GNPRas-related protein Rab-4A/0.533
1zd9GDPADP-ribosylation factor-like protein 8A/0.532
2bkuGTPGTP-binding nuclear protein Ran/0.532
3oiwGNPGTPase HRas/0.532
4dlxGNPGTPase HRas/0.532
4hdoGNPRas-related protein Rap-1b/0.531
4uj3GNPRas-related protein Rab-11A/0.530
4dlwGNPGTPase HRas/0.529
1g17GNPRas-related protein SEC4/0.528
1z0aGDPRas-related protein Rab-2A/0.526
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.526
4dsoGSPGTPase KRas/0.526
3w3zGTPGTP-binding nuclear protein Ran/0.525
4dsuGDPGTPase KRas/0.525
4l9wGNPGTPase HRas/0.525
4rkfGNPRas-related protein Rab-3/0.524
5c46GSPRas-related protein Rab-11A/0.524
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.522
5jljGNPGTP-binding nuclear protein Ran/0.522
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.521
2cl6CAGGTPase HRas/0.520
4dxaGSPRas-related protein Rap-1b/0.520
1d5cGDPGTPase (Rab6)/0.519
1zc4GNPRas-related protein Ral-A/0.519
3ea5GDPGTP-binding nuclear protein Ran/0.519
1e96GTPRas-related C3 botulinum toxin substrate 1/0.517
1tu3GNPRas-related protein Rab-5A/0.515
3oesGNPGTPase RhebL1/0.514
1zbdGTPRas-related protein Rab-3A/0.513
3th5GNPRas-related C3 botulinum toxin substrate 1/0.513
1ibrGNPGTP-binding nuclear protein Ran/0.512
1yzqGNPRas-related protein Rab-6A/0.512
3rabGNPRas-related protein Rab-3A/0.512
1t91GTPRas-related protein Rab-7a/0.511
4kvgGTPRas-related protein Rap-1A/0.510
1kmqGNPTransforming protein RhoA/0.508
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.507
4o25GTPGTP-binding protein Rheb/0.507
1zc3GNPRas-related protein Ral-A/0.505
3a6pGTPGTP-binding nuclear protein Ran/0.505
1cxzGSPTransforming protein RhoA/0.504
3bbpGTPRas-related protein Rab-6A/0.504
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.504
1s1cGNPTransforming protein RhoA/0.503
1oixGDPRas-related protein Rab-11A/0.502
3a58GNPGTP-binding protein RHO1/0.502
3kucGDPRas-related protein Rap-1A/0.501
4mitGTPRho-related protein racC/0.500
2q3fGNPRas-related GTP-binding protein D/0.498
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.498
3bc1GNPRas-related protein Rab-27A/0.498
1k5dGNPGTP-binding nuclear protein Ran/0.497
3e5hGNPRas-related protein Rab-28/0.496
2msdGNPMHC class I alpha chain/0.494
1vg8GNPRas-related protein Rab-7a/0.493
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.492
1z0dGDPRas-related protein Rab-5C/0.490
3d7zGK5Mitogen-activated protein kinase 14/0.490
3vhxGTPADP-ribosylation factor 6/0.490
4xclAGSHeat shock cognate 90 kDa protein/0.490
1xtrGNPGTP-binding protein Rheb/0.489
1ky2GNPGTP-binding protein YPT7/0.488
1v8kANPKinesin-like protein KIF2C/0.487
3eg5GNPCell division control protein 42 homolog/0.487
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.487
2zetGTPRas-related protein Rab-27B/0.486
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.485
5hpyGDPTransforming protein RhoA/0.485
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.484
1z2aGDPRas-related protein Rab-23/0.482
1rd4L08Integrin alpha-L/0.480
3cobADPKinesin heavy chain-like protein/0.479
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.478
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.478
3tqaNDPDihydrofolate reductase/0.477
4cf8V7HIntegrase/0.477
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.477
4y0vGDPADP-ribosylation factor 1, putative/0.477
1mvtDTMDihydrofolate reductase1.5.1.30.476
2ffqGSPRas-related protein Rab-6B/0.476
2x9dITCTetracycline repressor protein class D/0.476
3lawGNPRas-related protein Rab-7a/0.476
1m7bGTPRho-related GTP-binding protein RhoE/0.475
2gilGTPRas-related protein Rab-6A/0.475
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.475
4bn1ADPAurora kinase A2.7.11.10.475
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.474
3tnfGNPRas-related protein Rab-8A/0.474
1a2bGSPTransforming protein RhoA/0.473
2ovhAS0Progesterone receptor/0.473
4dc0NDPPutative ketoacyl reductase1.3.10.473
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.473
4xg1LLPDiaminopimelate decarboxylase/0.473
1s0xC3SNuclear receptor ROR-alpha/0.472
2pg0FADAcyl-CoA dehydrogenase/0.472
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
1l8qADPChromosomal replication initiator protein DnaA/0.471
3k7mFAD6-hydroxy-L-nicotine oxidase/0.471
3wyfGTPGTP-binding nuclear protein/0.470
4cjqVXOIntegrase/0.470
4ehv0SJMitogen-activated protein kinase 14/0.470
4o2lGTPGTP-binding protein Rheb/0.470
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.469
1ow3GDPTransforming protein RhoA/0.469
1pd9CO4Dihydrofolate reductase1.5.1.30.469
1z7yAA5Cysteine synthase 12.5.1.470.469
2p4iMR9Angiopoietin-1 receptor2.7.10.10.469
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.469
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.469
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.469
1dr5NAPDihydrofolate reductase1.5.1.30.468
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.468
2d4h5GPGuanylate-binding protein 1/0.468
2og81N8Tyrosine-protein kinase Lck2.7.10.20.468
2vo4GTB2,4-D inducible glutathione S-transferase/0.468
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.468
4k6fNAPPutative Acetoacetyl-CoA reductase/0.468
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
1a4rGNHCell division control protein 42 homolog/0.467
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.467
3akm11DFatty acid-binding protein, intestinal/0.467
4cidANPEH domain-containing protein 2/0.467
4jx1CAHCamphor 5-monooxygenase1.14.15.10.467
4l0qNADAlcohol dehydrogenase class-3/0.467
1dr3TAPDihydrofolate reductase1.5.1.30.466
1x2hLPALipoate-protein ligase A6.3.1.200.466
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2bbqPFGThymidylate synthase/0.466
2yg4FADPutrescine oxidase/0.466
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.465
1u1f183Uridine phosphorylase2.4.2.30.465
2a9y26AAdenosine kinase2.7.1.200.465
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.465
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.465
2pulACPMethylthioribose kinase2.7.1.1000.465
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.465
3pcrGTPADP-ribosylation factor 6/0.465
4d0lGSPRas-related protein Rab-11A/0.465
4ihjGTPTubulin alpha-1B chain/0.465
4o4fATPKinase/0.465
5iu86DZAdenosine receptor A2a/0.465
1ii6ADPKinesin-like protein KIF11/0.464
1pq944BOxysterols receptor LXR-beta/0.464
1xzqFONtRNA modification GTPase MnmE3.6.50.464
2c2aADPSensor histidine kinase/0.464
2iutAGSDNA translocase FtsK/0.464
3c1xCKKHepatocyte growth factor receptor2.7.10.10.464
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
4eevL1XHepatocyte growth factor receptor2.7.10.10.464
4yp7NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.464
1g6oADPCag alpha/0.463
1kt6RTLRetinol-binding protein 4/0.463
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.463
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.463
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.463
4jauADPSensor histidine kinase/0.463
4js0GNPCell division control protein 42 homolog/0.463
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.463
1fnnADPORC1-type DNA replication protein/0.462
1kquBR4Phospholipase A2, membrane associated/0.462
1zg32HIIsoflavone 4'-O-methyltransferase/0.462
2gcpGSPRho-related GTP-binding protein RhoC/0.462
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.462
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.462
3qlwN22Dihydrofolate reductase1.5.1.30.462
4ag5ADPType IV secretory pathway VirB4 components-like protein/0.462
4eh90OQMitogen-activated protein kinase 14/0.462
4jx1CAMCamphor 5-monooxygenase1.14.15.10.462
1bcpATPPertussis toxin subunit 4/0.461
1bcpATPPertussis toxin subunit 5/0.461
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1e0jANPDNA primase/helicase2.7.70.461
1n83CLRNuclear receptor ROR-alpha/0.461
1yhnGTPRas-related protein Rab-7a/0.461
1z6lFADPolyamine oxidase FMS1/0.461
1z95198Androgen receptor/0.461
3d84NDPDihydrofolate reductase1.5.1.30.461
3gkjHC3Niemann-Pick C1 protein/0.461
4ead0NPThymidine phosphorylase2.4.2.40.461
4g01GDPRas-related protein RABF2b/0.461
4mzuTYDWxcM-like protein/0.461
4u7wNDPMxaA/0.461
4wbnGTPTubulin alpha-1B chain/0.461
1hk3T44Serum albumin/0.460
2p1u4TNRetinoic acid receptor RXR-alpha/0.460
3lfeZ84Mitogen-activated protein kinase 14/0.460
3p2kSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.460
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.460
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4ylgGDPADP-ribosylation factor 1, putative/0.460
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.459
1z2cGNPRho-related GTP-binding protein RhoC/0.459
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
2c29NAPDihydroflavonol 4-reductase/0.459
2qbnCAMCamphor 5-monooxygenase1.14.15.10.459
2z4sADPChromosomal replication initiator protein DnaA/0.459
4bcoT6QCyclin-dependent kinase 22.7.11.220.459
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.459
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
2e0nSAHPrecorrin-2 C20-methyltransferase/0.458
2w71L23Biotin carboxylase6.3.4.140.458
2wi2ZZ3Heat shock protein HSP 90-alpha/0.458
3ha5SFGHydroxymycolate synthase MmaA42.1.10.458
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.458
4cf23GMIntegrase/0.458
4i3vNADAldehyde dehydrogenase (NAD+)/0.458
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.458
1z69F425,10-methylenetetrahydromethanopterin reductase/0.457
2qbmCAMCamphor 5-monooxygenase1.14.15.10.457
2yac937Serine/threonine-protein kinase PLK12.7.11.210.457
3ac2KSETyrosine-protein kinase Lck2.7.10.20.457
3d0bSNXHeat shock protein HSP 90-alpha/0.457
3q0gCOAProbable enoyl-CoA hydratase echA84.2.1.170.457
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.457
4b722FBBeta-secretase 13.4.23.460.457
4c2wANPAurora kinase B-A2.7.11.10.457
4ge1TSSBiogenic amine-binding protein/0.457
4ktkKTKCytochrome P450/0.457
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.457
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.456
2chlDKICasein kinase I isoform gamma-32.7.11.10.456
2y6fM9FIsopenicillin N synthase1.21.3.10.456
3bi2FADPolyamine oxidase FMS1/0.456
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.456
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.456
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.456
4ixd1HVIntegrin alpha-L/0.456
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.456
1ay0TPPTransketolase 12.2.1.10.455
1ia3TQ5Dihydrofolate reductase1.5.1.30.455
1mznBM6Retinoic acid receptor RXR-alpha/0.455
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
2hkoFADLysine-specific histone demethylase 1A10.455
2uxpCLMHTH-type transcriptional regulator TtgR/0.455
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3ibdCPZCytochrome P450 2B61.14.130.455
3t1tGDPProbable gliding protein mglA/0.455
3tk3CPZCytochrome P450 2B41.14.14.10.455
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.455
3zeiAWHO-acetylserine sulfhydrylase/0.455
4a1zADPKinesin-like protein KIF11/0.455
4pkwGM6Lethal factor3.4.24.830.455
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
5iqgGDPBifunctional AAC/APH2.3.10.455
5itzGTPTubulin alpha-1B chain/0.455
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.454
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.454
2l0xGDPGTP-binding protein Rheb/0.454
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.454
3b9lAZZSerum albumin/0.454
3ft5MO8Heat shock protein HSP 90-alpha/0.454
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.454
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.454
4bfvZVVPantothenate kinase2.7.1.330.454
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.454
4okb198Androgen receptor/0.454
5iu4ZMAAdenosine receptor A2a/0.454
1kt3RTLRetinol-binding protein 4/0.453
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.453
1sozVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.453
1t85CAMCamphor 5-monooxygenase1.14.15.10.453
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
2dxdANPNucleoside diphosphate kinase2.7.4.60.453
3bk2U5PRibonuclease J/0.453
3kroIPEGeranyl diphosphate synthase large subunit/0.453
4a9hTVPBromodomain-containing protein 2/0.453
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.453
4ifvFMQGag-Pol polyprotein2.7.7.490.453
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.453
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
5f0a1FBcGMP-dependent protein kinase, putative/0.453
3sn6P0GBeta-2 adrenergic receptor/0.453
1db48INPhospholipase A2, membrane associated/0.452
1hdrNADDihydropteridine reductase1.5.1.340.452
2az3CDPNucleoside diphosphate kinase/0.452
2c3qGTXGlutathione S-transferase theta-12.5.1.180.452
2g0lFLNNeocarzinostatin/0.452
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.452
2xtnGTPGTPase IMAP family member 2/0.452
2ydoADNAdenosine receptor A2a/0.452
2z6iFMN2-nitropropane dioxygenase/0.452
3da24MDCarbonic anhydrase 134.2.1.10.452
4fidGDPG protein alpha subunit, putative/0.452
1cbrREACellular retinoic acid-binding protein 1/0.451
1fmjRTLRetinol dehydratase/0.451
1hb3SCVIsopenicillin N synthase1.21.3.10.451
2dhfDZFDihydrofolate reductase1.5.1.30.451
2g8aUMPThymidylate synthase/0.451
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2pauD5M5'-deoxynucleotidase YfbR/0.451
2punACPMethylthioribose kinase2.7.1.1000.451
3ha7B32Hydroxymycolate synthase MmaA42.1.10.451
3iqeH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.451
3x2fNAIAdenosylhomocysteinase/0.451
4gh5NADShort-chain dehydrogenase/reductase SDR/0.451
4h9753SDihydrofolate reductase1.5.1.30.451
4p9dTMPDeoxycytidylate deaminase/0.451
4udqFAD5-(hydroxymethyl)furfural oxidase/0.451
4zm6ACON-acetyl-beta-D glucosaminidase/0.451
1oc1ASVIsopenicillin N synthase1.21.3.10.450
2r0cFADPutative FAD-monooxygenase/0.450
3gwnFADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.450
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.450
4ceqQCHIntegrase/0.450
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.450
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.450
4ktl1CQCytochrome P450/0.450
4m8e29VRetinoic acid receptor RXR-alpha/0.450
4okx198Androgen receptor/0.450
4zcaADPKinesin-like protein KIF11/0.450
5iqiGNPBifunctional AAC/APH2.3.10.450
5jlaNADPutative short-chain dehydrogenase/reductase/0.450
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1cqp803Integrin alpha-L/0.449
1hk4T44Serum albumin/0.449
1mewXMPInosine-5'-monophosphate dehydrogenase/0.449
1trgCB3Thymidylate synthase/0.449
1vzaUMPThymidylate synthase/0.449
1z2nADPInositol-tetrakisphosphate 1-kinase2.7.1.1340.449
1zrb062Prothrombin3.4.21.50.449
2a9z26AAdenosine kinase2.7.1.200.449
2yg5FADPutrescine oxidase/0.449
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.449
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3l0lHC3Nuclear receptor ROR-gamma/0.449
3refGDPRho family GTPase/0.449
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4i9bNADPutative betaine aldehyde dehyrogenase/0.449
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.449
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.449
5iubCLRAdenosine receptor A2a/0.449
1kt7RTLRetinol-binding protein 4/0.448
1t88CAMCamphor 5-monooxygenase1.14.15.10.448
2cdcNAPGlucose 1-dehydrogenase/0.448
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.448
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.448
2w6oOA3Biotin carboxylase6.3.4.140.448
3bj8COADiamine acetyltransferase 1/0.448
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.448
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.448
4b4vL34Bifunctional protein FolD/0.448
4bcqTJFCyclin-dependent kinase 22.7.11.220.448
4g47TZFMycocyclosin synthase1.14.21.90.448
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4rww2BALmo2692 protein/0.448
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
5di3GNPADP-ribosylation factor-like protein 3/0.448
5kf2COAPredicted acetyltransferase/0.448
1crbRTLRetinol-binding protein 1/0.447
1dz6CAMCamphor 5-monooxygenase1.14.15.10.447
1i5bANPChemotaxis protein CheA2.7.13.30.447
1njaDCMThymidylate synthase/0.447
1ot7CHCBile acid receptor/0.447
1rdtL79Retinoic acid receptor RXR-alpha/0.447
1rt7UC4Gag-Pol polyprotein2.7.7.490.447
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
1tduCB3Thymidylate synthase/0.447
1uyuCAMCamphor 5-monooxygenase1.14.15.10.447
2h2jSFGRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.447
2q4wFADCytokinin dehydrogenase 71.5.99.120.447
2r26CMCCitrate synthase2.3.3.160.447
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.447
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.447
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.447
3nbzGTPGTP-binding nuclear protein Ran/0.447
3qgd26SGenome polyprotein2.7.7.480.447
3qizQI2Botulinum neurotoxin type A3.4.24.690.447
4ctjSAMGenome polyprotein/0.447
4eomATPCyclin-dependent kinase 22.7.11.220.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
4hy6FJ1Heat shock protein HSP 90-alpha/0.447
4ips1G4Mycocyclosin synthase1.14.21.90.447
4k39SAMAnaerobic sulfatase-maturating enzyme1.8.980.447
4l9q9TPSerum albumin/0.447
4nmbFADBifunctional protein PutA/0.447
1knuYPAPeroxisome proliferator-activated receptor gamma/0.446
2g8dUMPThymidylate synthase/0.446
2rm2W43Genome polyprotein/0.446
2vcj2EQHeat shock protein HSP 90-alpha/0.446
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.446
3ctj320Hepatocyte growth factor receptor2.7.10.10.446
3p3zP3ZPutative cytochrome P450/0.446
3q5dGDPAtlastin-13.6.50.446
3rsv3RSBeta-secretase 13.4.23.460.446
3tmz06XCytochrome P450 2B41.14.14.10.446
4g2i0VQVitamin D3 receptor/0.446
4h2w5GPAmino acid--[acyl-carrier-protein] ligase 16.2.1.n20.446
4lv5ADPRhoptry protein 5B/0.446
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.446
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.446
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.445
1dr2TAPDihydrofolate reductase1.5.1.30.445
1eioGCHGastrotropin/0.445
1kl2FONSerine hydroxymethyltransferase/0.445
1s3uTQDDihydrofolate reductase1.5.1.30.445
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.445
2pupADPMethylthioribose kinase2.7.1.1000.445
2qu5276Vascular endothelial growth factor receptor 22.7.10.10.445
2v7qADPATP synthase subunit beta, mitochondrial3.6.3.140.445
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.445
2vyvNADGlyceraldehyde-3-phosphate dehydrogenase A/0.445
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.445
2yi7BZ8Heat shock protein HSP 90-alpha/0.445
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.445
4anbYQYDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
4cf7ADPAdenylate kinase/0.445
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4itrGDPCell division control protein 42 homolog/0.445
4lb2DM5Serum albumin/0.445
4mv1ADPBiotin carboxylase6.3.4.140.445
4qmzB49Serine/threonine-protein kinase 242.7.11.10.445
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
1dz4CAMCamphor 5-monooxygenase1.14.15.10.444
1g28FMNPHY3/0.444
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
1xlsREARetinoic acid receptor RXR-alpha/0.444
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.444
2c9ePIDPeridinin-chlorophyll a protein, high-salt form/0.444
2ovmAS0Progesterone receptor/0.444
2wi6ZZ6Heat shock protein HSP 90-alpha/0.444
2wvlGDDMannosyl-3-phosphogylcerate synthase/0.444
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3fwiCAMCamphor 5-monooxygenase1.14.15.10.444
3pqbVGPPutative oxidoreductase/0.444
3qt62P0Mevalonate diphosphate decarboxylase/0.444
3tfq07MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.444
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.444
4ck2NVUIntegrase/0.444
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.444
4iarERM5-hydroxytryptamine receptor 1B/0.444
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.444
4u7tSAHDNA (cytosine-5)-methyltransferase 3A2.1.1.370.444
1am4GNPCell division control protein 42 homolog/0.443
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.443
1hb1OCVIsopenicillin N synthase1.21.3.10.443
1jlrGTPUracil phosphoribosyltransferase/0.443
1qjfACSIsopenicillin N synthase1.21.3.10.443
1youPFDCollagenase 33.4.240.443
1zgaHMKIsoflavone 4'-O-methyltransferase/0.443
2bxqIMNSerum albumin/0.443
2chtTSAChorismate mutase AroH5.4.99.50.443
2pxaSAHGenome polyprotein2.7.7.480.443
3dd125DGlycogen phosphorylase, liver form2.4.1.10.443
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.443
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
3to3ATPPetrobactin biosynthesis protein AsbB/0.443
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.443
4cerVL4Integrase/0.443
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.443
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.443
4yaoFMNNADPH--cytochrome P450 reductase/0.443
5jqgGTPTubulin alpha-1B chain/0.443
1culFOKAdenylate cyclase type 2/0.442
1culFOKAdenylate cyclase type 5/0.442
1nhz486Glucocorticoid receptor/0.442
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.442
1yhjR6CPyridoxal kinase2.7.1.350.442
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.442
2bfyH1NAurora kinase B-A2.7.11.10.442
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
2h2eSA8Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.442
2uwd2GGHeat shock protein HSP 90-alpha/0.442
3a9wNADNDP-sugar epimerase/0.442
3h0a9RARetinoic acid receptor RXR-alpha/0.442
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
3n0bFADFlavin-dependent thymidylate synthase2.1.1.1480.442
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.442
3pn1IVHDNA ligase/0.442
3qiyQI1Botulinum neurotoxin type A3.4.24.690.442
3ts4EEGMacrophage metalloelastase3.4.24.650.442
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
3vi5M4MHematopoietic prostaglandin D synthase/0.442
3wqtANPCell division protein FtsA/0.442
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.442
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.442
4awp99AHeat shock protein HSP 90-alpha/0.442
4iah1DXAlr2278 protein/0.442
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.442
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.442
4m6p20RNicotinamide phosphoribosyltransferase2.4.2.120.442
4oadCLMUncharacterized protein/0.442
4orkGDPBifunctional AAC/APH2.3.10.442
4tx9AMZPhosphoribosyl isomerase A/0.442
1osvCHCBile acid receptor/0.441
1vf2GTXGlutathione S-transferase 32.5.1.180.441
2bakAQZMitogen-activated protein kinase 14/0.441
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
2fonFADAcyl-coenzyme A oxidase/0.441
2j0vGDPRac-like GTP-binding protein ARAC7/0.441
2rr1W8RGenome polyprotein/0.441
2yyuC5POrotidine 5'-phosphate decarboxylase/0.441
3akn11DFatty acid-binding protein, intestinal/0.441
3f8pNADNADH oxidase/thioredoxin reductase/0.441
3k3bADPKinesin-like protein KIF11/0.441
3kz1GSPTransforming protein RhoA/0.441
3mohGDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.441
3pndFADFAD:protein FMN transferase/0.441
4a9yAQZMitogen-activated protein kinase 14/0.441
4jq8KJ8Epidermal growth factor receptor2.7.10.10.441
4k6i9RARetinoic acid receptor RXR-alpha/0.441
4ke11R6Beta-secretase 13.4.23.460.441
4kko1REGag-Pol polyprotein2.7.7.490.441
4kkyCAMCamphor 5-monooxygenase1.14.15.10.441
4l9kEHFSerum albumin/0.441
4okw198Androgen receptor/0.441
4q71FADBifunctional protein PutA/0.441
5je3SAHMethyl transferase/0.441
5k2dZMAAdenosine receptor A2a/0.441
1m78NDPDihydrofolate reductase1.5.1.30.440
1n4hREANuclear receptor ROR-beta/0.440
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.440
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.440
1nq7ARLNuclear receptor ROR-beta/0.440
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1q6p213Tyrosine-protein phosphatase non-receptor type 13.1.3.480.440
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.440
2oegUPGUDP-glucose pyrophosphorylase/0.440
2vczVC3Hematopoietic prostaglandin D synthase/0.440
2yeiXQIHeat shock protein HSP 90-alpha/0.440
2zevB71Geranylgeranyl pyrophosphate synthase/0.440
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.440
3c9tTPSThiamine-monophosphate kinase/0.440
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.440
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3g5hYTTMycocyclosin synthase1.14.21.90.440
3pghFLPProstaglandin G/H synthase 21.14.99.10.440
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.440
3r1kCOAN-acetyltransferase Eis/0.440
3tk0FADFAD-linked sulfhydryl oxidase ALR1.8.3.20.440
3wrmCAMCamphor 5-monooxygenase1.14.15.10.440
3wtkTH4Acetylcholine-binding protein/0.440
4cigX0PIntegrase/0.440
4gojGNPADP-ribosylation factor-like protein 3/0.440
4nmdFDABifunctional protein PutA/0.440
4yj2GTPTubulin alpha-1B chain/0.440
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.440
5iqaGNPBifunctional AAC/APH2.3.10.440
5uviZMAAdenosine receptor A2a/0.440