sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 1.000 | |
| 4qec | NAP | ElxO | / | 0.525 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.520 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.520 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.516 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.515 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.515 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.514 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.513 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.512 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.510 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.509 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.504 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.501 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.498 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.497 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.495 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.495 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.494 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.493 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.492 | |
| 3sju | NDP | Keto reductase | / | 0.492 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.489 | |
| 1sny | NAP | LD36273p | / | 0.488 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.488 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.487 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.486 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.484 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.482 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.481 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.479 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.479 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.476 | |
| 4qed | NAP | ElxO | / | 0.474 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.473 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.473 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.473 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.472 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.472 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.472 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.471 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.471 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.471 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.468 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.467 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.465 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.461 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.459 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.458 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.456 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.455 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.454 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.454 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.454 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.453 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.453 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.452 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.449 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.449 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.447 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.447 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.447 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.446 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.443 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.443 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.440 |